Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach

Autor: Johan J.P. Gille, Charlotte J. Dommering, Jan P. Schouten, D. de Jong, Cathal J. McElgunn, J Th Wijnen, R J van Schooten, Gerard Pals, Gerrit A. Meijer, Fred H. Menko, M. E. Craanen, Petra M. Nederlof, Frans B. L. Hogervorst

Publikováno v: Gille, J J P, Hogervorst, F B L, Pals, G, Wijnen, J T, van Schooten, R J, Dommering, C J, Meijer, G A, Craanen, M E, Nederlof, P M, de Jong, D, McElgunn, C J, Schouten, J P & Menko, F H 2002, ' Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach ', British Journal of Cancer, vol. 87, no. 8, pp. 892-7 . https://doi.org/10.1038/sj.bjc.6600565
British Journal of Cancer, 87(8), 892-7. Nature Publishing Group
British Journal of Cancer

Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair genes, in particular MLH1, MSH2 and MSH6. Here we describe the application of a novel technique for the detection of genomi

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https://research.vumc.nl/en/publications/ffbcdafb-f407-4cf3-937d-1d8b8a2640c1