Zobrazeno 1 - 10
of 22
pro vyhledávání: '"R J Seager"'
Autor:
Jeffrey M Conroy, Sarabjot Pabla, Sean T Glenn, R J Seager, Erik Van Roey, Shuang Gao, Blake Burgher, Jonathan Andreas, Vincent Giamo, Melissa Mallon, Yong Hee Lee, Paul DePietro, Mary Nesline, Yirong Wang, Felicia L Lenzo, Roger Klein, Shengle Zhang
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260089 (2021)
Timely and accurate identification of molecular alterations in solid tumors is essential for proper management of patients with advanced cancers. This has created a need for rapid, scalable comprehensive genomic profiling (CGP) systems that detect an
Externí odkaz:
https://doaj.org/article/5d34c3b03cac4c3d8f34c82b35db33d5
Autor:
Santosh Kesari, Alexandre Wojcinski, Sarabjot Pabla, R. J. Seager, Jaya M. Gill, Jose A. Carrillo, Naveed Wagle, David J. Park, Minhdan Nguyen, Judy Truong, Yuki Takasumi, Lisa Chaiken, Shu-Ching Chang, Garni Barkhoudarian, Daniel F. Kelly, Tiffany M. Juarez
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
The limited success of immune checkpoint inhibitors (ICIs) in the adjuvant setting for glioblastoma highlights the need to explore administering ICIs prior to immunosuppressive radiation. To address the feasibility and safety of this approach, we con
Externí odkaz:
https://doaj.org/article/ae68770243fe4ed9a2afd9d7e559875b
Autor:
R. J. Seager, Maria-Fernanda Senosain, Erik Van Roey, Shuang Gao, Paul DePietro, Mary K. Nesline, Durga Prasad Dash, Shengle Zhang, Heidi Ko, Stephanie B. Hastings, Kyle C. Strickland, Rebecca A. Previs, Taylor J. Jensen, Marcia Eisenberg, Brian J. Caveney, Eric A. Severson, Shakti Ramkissoon, Jeffrey M. Conroy, Sarabjot Pabla
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression drives the metastasis and progression of lung cancer, and is associated
Externí odkaz:
https://doaj.org/article/c349be77b0f14a3eaaf56d8588b10579
Autor:
Shrunjal Shah, Sai Yendamuri, Charles Roche, Jeffrey M. Conroy, R J Seager, Randall J. Smith, Eric Kannisto, Kris Attwood, Santosh K. Patnaik, Rohit Gosain, Robert Zollo, Stephanie N. Sass, Joseph Barbi, Xialong Wang, Aravind Srinivasan, Cara Petrucci, Sarabjot Pabla
Publikováno v:
J Thorac Oncol
Introduction Although obesity is associated with adverse cancer outcomes in general, most retrospective clinical studies suggest a beneficial effect of obesity in NSCLC. Methods Hypothesizing that this “obesity paradox” arises partly from the lim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914e78b5c6786ca6ffd92928204f133
https://doi.org/10.1016/j.jtho.2021.04.020
https://doi.org/10.1016/j.jtho.2021.04.020
Autor:
Jonathan Andreas, Vincent Giamo, Blake Burgher, Yirong Wang, Margot Schoenborn, Roger Klein, Erik Van Roey, Mary Nesline, Shengle Zhang, Felicia L. Lenzo, Shuang Gao, Sarabjot Pabla, Paul DePietro, R J Seager, Jeffrey M. Conroy, Sean T. Glenn, Carrie Hoefer
Publikováno v:
Biomarker Research, Vol 9, Iss 1, Pp 1-11 (2021)
Biomarker Research
Biomarker Research
Background Contemporary to the rapidly evolving landscape of cancer immunotherapy is the equally changing understanding of immune tumor microenvironments (TMEs) which is crucial to the success of these therapies. Their reliance on a robust host immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaf3184e0d9805b506b7c8016daa7fe
https://doaj.org/article/8e4c928eb92647248416cdd788777bec
https://doaj.org/article/8e4c928eb92647248416cdd788777bec
Autor:
Sarbajit Mukherjee, R. J. Seager, Yong Hee Lee, Jeffrey M. Conroy, Pawel Kalinski, Sarabjot Pabla
Publikováno v:
Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1324
Journal of Personalized Medicine, Vol 11, Iss 1324, p 1324 (2021)
Journal of Personalized Medicine
Journal of Personalized Medicine, Vol 11, Iss 1324, p 1324 (2021)
Journal of Personalized Medicine
Recent epidemiological studies have shown that obesity, typically measured by increased body mass index (BMI), is associated with an increased risk of gastroesophageal adenocarcinoma (GEAC), but the contributing molecular and immune mechanisms remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111c70cd26c344fb8c062c7871ad6f0c
Autor:
Vincent Giamo, Blake Burgher, Mary Nesline, Yong Hee Lee, Jeffrey M. Conroy, Roger Klein, Paul DePietro, R J Seager, Sarabjot Pabla, Erik Van Roey, Sean T. Glenn, Shuang Gao, Shengle Zhang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundImmune checkpoint inhibitor-based therapies have achieved impressive success in the treatment of several cancer types. Predictive immune biomarkers, including PD-L1, MSI and TMB are well established as surrogate markers for immune evasion a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d633c6d35ff121ae0a87319a921c1b
https://doaj.org/article/f0dc15de13274af0bda7dc77d8721c12
https://doaj.org/article/f0dc15de13274af0bda7dc77d8721c12
Autor:
R J Seager, Sarabjot Pabla, B R Achyut, Mary Nesline, Geoffrey Kannan, Anjen Chenn, Shengle Zhang, Roger Klein, Jeffrey Conroy, Mark Sausen, Kamal Saini, Taylor Jensen, Prasanth Reddy, Eric Severson, Shakti Ramkissoon
Publikováno v:
Neuro-Oncology. 24:vii4-vii4
BACKGROUND Non-small cell lung cancer (NSCLC) accounts for ~50% of brain metastases. We present the genomic and immune biomarker landscape for a cohort with metastatic NSCLC to the brain. METHODS We analyzed brain metastases FFPE tissue (n=137; ages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d06eb6f914892f5147fdaca60a06119f
https://doi.org/10.1093/neuonc/noac209.013
https://doi.org/10.1093/neuonc/noac209.013
Autor:
Shuang Gao, Blake Burgher, Shengle Zhang, Sean T. Glenn, Roger Klein, Vincent Giamo, Sarabjot Pabla, Melissa Mallon, Erik Van Roey, Jonathan Andreas, Yirong Wang, Paul DePietro, R J Seager, Mary Nesline, Felicia L. Lenzo, Yong Hee Lee, Jeffrey M. Conroy
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260089 (2021)
PLoS ONE
PLoS ONE
Timely and accurate identification of molecular alterations in solid tumors is essential for proper management of patients with advanced cancers. This has created a need for rapid, scalable comprehensive genomic profiling (CGP) systems that detect an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04d975e900fb0eb83a476e52c655550f
https://doaj.org/article/5d34c3b03cac4c3d8f34c82b35db33d5
https://doaj.org/article/5d34c3b03cac4c3d8f34c82b35db33d5
Autor:
Felix Litvak, Alrina Shin Min Tan, Je Lin Sieow, Hweixian Leong Penny, Fabian Spill, Sharon Wei Ling Lee, R J Seager, Siew Cheng Wong, Dillip Kumar, Roger D. Kamm, Muhammad H. Zaman, Giulia Adriani
Publikováno v:
Integr Biol (Camb)
Macrophages are abundant in the tumor microenvironment (TME), serving as accomplices to cancer cells for their invasion. Studies have explored the biochemical mechanisms that drive pro-tumor macrophage functions, however the role of TME interstitial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f03f09bafb734486ca5eb21289e1523
