Pre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas

Autor: Santosh Kesari, Alexandre Wojcinski, Sarabjot Pabla, R. J. Seager, Jaya M. Gill, Jose A. Carrillo, Naveed Wagle, David J. Park, Minhdan Nguyen, Judy Truong, Yuki Takasumi, Lisa Chaiken, Shu-Ching Chang, Garni Barkhoudarian, Daniel F. Kelly, Tiffany M. Juarez

Publikováno v: OncoImmunology, Vol 13, Iss 1 (2024)

The limited success of immune checkpoint inhibitors (ICIs) in the adjuvant setting for glioblastoma highlights the need to explore administering ICIs prior to immunosuppressive radiation. To address the feasibility and safety of this approach, we con

Externí odkaz: https://doaj.org/article/ae68770243fe4ed9a2afd9d7e559875b

Integration of tumor inflammation, cell proliferation, and traditional biomarkers improves prediction of immunotherapy resistance and response

Autor: Sarabjot Pabla, R. J. Seager, Erik Van Roey, Shuang Gao, Carrie Hoefer, Mary K. Nesline, Paul DePietro, Blake Burgher, Jonathan Andreas, Vincent Giamo, Yirong Wang, Felicia L. Lenzo, Margot Schoenborn, Shengle Zhang, Roger Klein, Sean T. Glenn, Jeffrey M. Conroy

Publikováno v: Biomarker Research, Vol 9, Iss 1, Pp 1-11 (2021)

Abstract Background Contemporary to the rapidly evolving landscape of cancer immunotherapy is the equally changing understanding of immune tumor microenvironments (TMEs) which is crucial to the success of these therapies. Their reliance on a robust h

Externí odkaz: https://doaj.org/article/8e4c928eb92647248416cdd788777bec

Visceral Obesity Promotes Lung Cancer Progression—Toward Resolution of the Obesity Paradox in Lung Cancer

Autor: Shrunjal Shah, Sai Yendamuri, Charles Roche, Jeffrey M. Conroy, R J Seager, Randall J. Smith, Eric Kannisto, Kris Attwood, Santosh K. Patnaik, Rohit Gosain, Robert Zollo, Stephanie N. Sass, Joseph Barbi, Xialong Wang, Aravind Srinivasan, Cara Petrucci, Sarabjot Pabla

Publikováno v: J Thorac Oncol

Introduction Although obesity is associated with adverse cancer outcomes in general, most retrospective clinical studies suggest a beneficial effect of obesity in NSCLC. Methods Hypothesizing that this “obesity paradox” arises partly from the lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8914e78b5c6786ca6ffd92928204f133
https://doi.org/10.1016/j.jtho.2021.04.020

Tumor Inflammation, Obesity, and Proliferative Status as Biomarkers in Gastroesophageal Adenocarcinoma

Autor: Sarbajit Mukherjee, R. J. Seager, Yong Hee Lee, Jeffrey M. Conroy, Pawel Kalinski, Sarabjot Pabla

Publikováno v: Journal of Personalized Medicine; Volume 11; Issue 12; Pages: 1324
Journal of Personalized Medicine, Vol 11, Iss 1324, p 1324 (2021)
Journal of Personalized Medicine

Recent epidemiological studies have shown that obesity, typically measured by increased body mass index (BMI), is associated with an increased risk of gastroesophageal adenocarcinoma (GEAC), but the contributing molecular and immune mechanisms remain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::111c70cd26c344fb8c062c7871ad6f0c

BIOM-03. COMPREHENSIVE GENOMIC AND IMMUNE PROFILING OF NON-SMALL CELL LUNG CANCER BRAIN METASTASES REVEALS LOW TUMOR INFLAMMATION AND ELEVATED CANCER TESTIS ANTIGEN BURDEN

Autor: R J Seager, Sarabjot Pabla, B R Achyut, Mary Nesline, Geoffrey Kannan, Anjen Chenn, Shengle Zhang, Roger Klein, Jeffrey Conroy, Mark Sausen, Kamal Saini, Taylor Jensen, Prasanth Reddy, Eric Severson, Shakti Ramkissoon

Publikováno v: Neuro-Oncology. 24:vii4-vii4

BACKGROUND Non-small cell lung cancer (NSCLC) accounts for ~50% of brain metastases. We present the genomic and immune biomarker landscape for a cohort with metastatic NSCLC to the brain. METHODS We analyzed brain metastases FFPE tissue (n=137; ages

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d06eb6f914892f5147fdaca60a06119f
https://doi.org/10.1093/neuonc/noac209.013