Zobrazeno 1 - 10
of 23
pro vyhledávání: '"R J Ruch"'
Publikováno v:
Progress in Organic Coatings. 28:17-20
Evidence that the adsorption of polymers produces significant changes in the bulk properties of polymers at great distances from the original surface site of the macromolecule is discussed. This long range effect, or the interphase as it has become k
Publikováno v:
Journal of Biological Chemistry. 268:17384-17391
Employing reporter gene/CYP1A1 chimeric plasmids, we previously identified a 275-base pair (bp) cis-element (-833 to -558; NRE275) that down-regulated the CYP1A1 promoter. In the present study, this negative regulatory activity was further localized
Autor:
L, Koffler, S, Roshong, I, Kyu Park, K, Cesen-Cummings, D C, Thompson, L D, Dwyer-Nield, P, Rice, C, Mamay, A M, Malkinson, R J, Ruch
Publikováno v:
Journal of cellular biochemistry. 79(3)
Gap junctional intercellular communication (GJIC) and connexin expression are frequently decreased in neoplasia and may contribute to defective growth control and loss of differentiated functions. GJIC, in E9 mouse lung carcinoma cells and WB-aB1 neo
Autor:
R J, Ruch, J E, Trosko
Publikováno v:
Anticancer research. 19(6A)
The role of oval cells, and Gap Junctional Intercellular Communication (GJIC) in hepatic differentiation and neoplasia is controversial. Oval cells accumulate in great number when hepatocyte regeneration is blocked following massive hepatotoxicity or
Publikováno v:
Anticancer research. 18(6A)
Protein kinase C (PKC) activity is increased and gap junctional intercellular communication (GJIC) is decreased frequently in Ras-transformed cells. We investigated the roles of Ras and PKC in the deficient gap junctional intercellular communication
Publikováno v:
Molecular carcinogenesis. 22(2)
Gap-junctional intercellular communication (GJIC) is involved in cellular growth control and is often reduced in neoplastic cells. In this study, four GJIC-deficient rat liver epithelial cell lines (WB-aB1, WB-bA2, WB-cD6, and WB-dA2) were examined f
Publikováno v:
The American journal of physiology. 271(6 Pt 1)
Cytosolic inorganic phosphate (P(i)) is important for glucose metabolism. It plays a role in homeostatic regulation of glucose by insulin and glucagon. Recently, we isolated two cDNA clones for rat Na+/P(i) cotransporter-1 (rNaPi-1) and demonstrated
Publikováno v:
Anticancer research. 16(6B)
Reduced gap junctional intercellular communication (GJIC) occurs in neoplastic cells and contributes to their phenotype. Cyclic AMP agonists inhibit lung cancer cell growth and enhance GIIC in other cell types, but little is known about their effects
Publikováno v:
Molecular carcinogenesis. 16(4)
Clones of rat liver epithelial cells genotypically altered by mutation or by a variety of oncogenes were analyzed by microinjection-dye transfer, immunofluorescence confocal microscopy, and western blotting to determine at what level and to what degr
Publikováno v:
Molecular carcinogenesis. 16(3)
Gap-junction channels connect the interiors of adjacent cells and can be arranged into aggregates or plaques consisting of hundreds to thousands of channel particles. The mechanism of channel aggregation into plaques and whether plaques can disaggreg