Zobrazeno 1 - 10
of 59
pro vyhledávání: '"R J Leeming"'
Publikováno v:
Nutrition Research. 23:1463-1475
Several molecular mechanisms that underpin genomic integrity and function are sensitive to B-vitamin status, and in particular, are responsive to the interaction between folate nutrition and folate dependent enzyme polymorphisms. Mechanisms that may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::112f3a3ff6ab2188a4a2ce2ae7f7056e
https://doi.org/10.1016/s0271-5317(03)00156-8
https://doi.org/10.1016/s0271-5317(03)00156-8
Publikováno v:
Molecular Genetics and Metabolism. 65:291-297
Data are presented to support the hypothesis that the biopterin content of red blood cells arises during erythropoiesis. Only when the plasma concentration rises above the erythrocyte concentration of biopterin is there likely to be diffusion into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbdb532793dc508986e60c7640b58b71
https://doi.org/10.1006/mgme.1998.2766
https://doi.org/10.1006/mgme.1998.2766
Autor:
R. J. Leeming, Mark Lucock
Publikováno v:
Medical hypotheses. 80(6)
An argument is put forward for environmental modulators of photolabile or photosynthetic vitamins mediating autism risk via a complex downstream interaction of genetic/epigenetic phenomena that provide an explanation for seasonality in this and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31a4b4ca3ce36a04934a1ce7fa37bd4
https://pubmed.ncbi.nlm.nih.gov/23566657
https://pubmed.ncbi.nlm.nih.gov/23566657
Autor:
Gillian Farrar, M.T. Abou-Saleh, M. Wesson, J.A. Blair, R. J. Leeming, D. N. Anderson, Andrew M. Wilkinson
Publikováno v:
Journal of Affective Disorders. 32:163-168
Serum 5-MeTHF levels are reported in 26 subjects, before and after completing a course of ECT, and compared to 21 healthy volunteers. 5-MeTHF levels of depressed subjects were significantly lower than controls before and after ECT. There was no diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d09e3c865eedd7d32b5ad51e82e738
https://doi.org/10.1016/0165-0327(94)90014-0
https://doi.org/10.1016/0165-0327(94)90014-0
Publikováno v:
Journal of Human Nutrition and Dietetics. 5:237-244
5-methyltetrahydrofolate, the most bioavailable folate was measured by high-performance liquid chromatography in the British total diet study, a survey designed primarily to monitor food contaminants. A total 5 MeTHF of 130.1 μg (±21.7, n=6) was me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f81ab66e9109520dfce9d83bf01f59b
https://doi.org/10.1111/j.1365-277x.1992.tb00158.x
https://doi.org/10.1111/j.1365-277x.1992.tb00158.x
Autor:
Mark Lucock, R. J. Leeming
Publikováno v:
Journal of inherited metabolic disease. 32(3)
Autism is increasing—but why? Birth defect prevention trials were based on the teleological assumption that folic acid could prevent neural tube defects without consideration of long-term effects, some of which could be beneficial, some of which mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63443f6eb4cb779e3352f96f768c197b
https://pubmed.ncbi.nlm.nih.gov/19277892
https://pubmed.ncbi.nlm.nih.gov/19277892
Publikováno v:
Molecular genetics and metabolism. 76(4)
Several reports indicate that biopterin and folate pathways may interact. We examined folate metabolism in PKU patients where hyperphenylalaninaemia leads to a likely excess of THB. We found an increase in total HPLC determined red cell folate in PKU
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfb92d9ab4ab4d72d371d4382280151e
https://pubmed.ncbi.nlm.nih.gov/12208135
https://pubmed.ncbi.nlm.nih.gov/12208135
Autor:
S. Kate Hall, R. J. Leeming
Publikováno v:
Pteridines, Vol 21, Iss 1, Pp 84-85 (2010)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72e2a21e62232091b7e7ac9c0df1d953
https://doi.org/10.1515/pteridines.2010.21.1.84
https://doi.org/10.1515/pteridines.2010.21.1.84
Publikováno v:
European Journal of Pediatrics. 149:713-715
Tetrahydrobiopterin (BH4) deficiency is a rare cause of hyperphenylalaninaemia (HPA) and usually leads to progressive neurological deterioration despite early dietary control of plasma phenylalanine concentrations. Dihydropteridine reductase (DHPR) d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fbf394f8949d29420570d08d546b4e
https://doi.org/10.1007/bf01959529
https://doi.org/10.1007/bf01959529
Autor:
R. J. Leeming, S. Kate Hall
Publikováno v:
Pteridines, Vol 17, Iss 4, Pp 101-102 (2006)
That dihydropteridine reductase (DHPR) has a key role to play in folate metabolism in the CNS is made clear by low concentrations of folate species in the CSF and blood of patients with DHPR deficiency. CSF folate concentrations, for reasons not yet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fc1bd6e8b347488c4fed4915a4ea73
https://doi.org/10.1515/pteridines.2006.17.4.101
https://doi.org/10.1515/pteridines.2006.17.4.101