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Potency of Antileukoprotease and α1-Antitrypsin to Inhibit Degradation of Fibrinogen by Adherent Polymorphonuclear Leukocytes from Normal Subjects and Patients with Chronic Granulomatous Disease

Autor: Johannes A. Kramps, Richard A. Mumford, William A. Hanlon, Philip Davies, W. B. Knight, R. J. Bonney, Joop H. Dijkman, Barbara G. Green, John J. Humes, Jan Stolk

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 6:521-526

We have studied the relative efficacy of antileukoprotease (ALP) and alpha 1-antitrypsin (alpha 1AT) to inhibit the degradation of substrate by polymorphonuclear leukocytes (PMN) attached onto a fibrinogen matrix. PMN elastase activity was assayed by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a496210c32b6e35e90a533a71f35bce
https://doi.org/10.1165/ajrcmb/6.5.521

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Prevention of human leukocyte elastase-mediated lung damage by 3-alkyl-4-azetidinones

Autor: Daniel S. Fletcher, M.Ellen Dahlgren, Bonnie M. Ash, Philip Davies, Conrad P. Dorn, Donald G. Osinga, H. Weston, Shrenik K. Shah, R. J. Bonney, Pau.E. Finke, Pam S. Dellea, Jeffrey J. Hale, William K. Hagmann, Karen A. Brause, Kevan R. Thompson, Karen M. Hand, Alan L. Maycock, James B. Doherty, Laura A. O'Grady

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 1:545-550

Simple 3-alkyl-4-azetidinones have been previously reported as potent inhibitors of human leukocyte elastase (HLE). Further modification of these simple monocyclic β-lactams has led to development of substituted 4-azetidinones that both inhibit HLE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c2e5dd4773968a0e79fe011922e132
https://doi.org/10.1016/s0960-894x(01)80463-7

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A Comparison of α1-Proteinase Inhibitor Methoxysuccinyl-Ala-Ala-Pro-Val-Chloromethylketone and Specific β-Lactam Inhibitors in an Acute Model of Human Polymorphonuclear Leukocyte Elastase-induced Lung Hemorrhage in the Hamster

Autor: Donald G. Osinga, Paul E. Finke, William K. Hagmann, Philip Davies, Daniel S. Fletcher, Pam S. Dellea, Karen M. Hand, Richard A. Mumford, James B. Doherty, R. J. Bonney, Bonnie M. Ashe

Publikováno v: American Review of Respiratory Disease. 141:672-677

A pharmacokinetic model is described for testing of polymorphonuclear leukocyte (PMN) elastase inhibitors administered by intratracheal or aerosol dosing of hamsters. Acute lung injury, measured as hemorrhage occurring within hours after intratrachea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27824b6dc1ccb8aa8818210f02cece0a
https://doi.org/10.1164/ajrccm/141.3.672

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An inhibitor of leukocyte elastase prevents immune complex-mediated hemorrhage in the rat lung

Autor: D S, Fletcher, D G, Osinga, K, Keenan, R J, Bonney, J B, Doherty, P E, Finke, S K, Shah, P, Davies

Publikováno v: The Journal of pharmacology and experimental therapeutics. 274(1)

The typical reverse passive Arthus reaction (RPA) was attained in rats by the instillation of a rabbit antiovalbumin serum into the lungs and intravenous injection of ovalbumin. Instillation of antiserum alone caused accumulation of polymorphonuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e56ffe0ec626c1307ed031b43d96d972
https://pubmed.ncbi.nlm.nih.gov/7616444

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Inhibitor of phospholipase A2 blocks eicosanoid and platelet activating factor biosynthesis and has topical anti-inflammatory activity

Autor: K M, Tramposch, F H, Chilton, P L, Stanley, R C, Franson, M B, Havens, D O, Nettleton, L B, Davern, I M, Darling, R J, Bonney

Publikováno v: The Journal of pharmacology and experimental therapeutics. 271(2)

The effect of a phospholipase A2 (PLA2) inhibitor on leukotriene, prostaglandin and platelet activating factor (PAF) biosynthesis in isolated cells and in vivo was determined. BMS-181162, [4(3'-carboxyphenyl)-3,7-dimethyl-9(2",6",6"-trimethyl-1"- cyc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95826377cee77a81e5c2b75a32d8d949
https://pubmed.ncbi.nlm.nih.gov/7965805

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Inhibition of human leukocyte elastase. 4. Selection of a substituted cephalosporin (L-658,758) as a topical aerosol

Autor: Thomas J. Blacklock, Philip Davies, Richard G. Ball, Karen A. Brause, R. J. Bonney, P. E. Finke, M Cotton, Bonnie M. Ashe, G. O. Chandler, S. K. Shah

Publikováno v: Journal of medicinal chemistry. 35(21)

Human leukocyte elastase (HLE) is a serine protease which has been implicated as a causative agent in several pulmonary diseases. The continued modification of our previously reported cephalosporin-based HLE inhibitors has led to the identification o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9887b138fa53b88a0048809a71d2419
https://pubmed.ncbi.nlm.nih.gov/1433188

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The pharmacology of a novel topical retinoid, BMY 30123: comparison with tretinoin

Autor: R J Bonney, Kenneth M. Tramposch, Gary Whiting, Gerard J. Gendimenico, G. Tetrault, I Kiss, Xina Nair, Simon Chen

Publikováno v: The Journal of pharmacy and pharmacology. 44(5)

Preclinical studies pertaining to the pharmacology and toxicology of BMY 30123 (4-acetamidophenyl retinoate) are reported. BMY 30123 is a novel compound which has topical retinoid activity. This compound exhibits lower toxicity, both local and system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec92d7c7d96721f818e0d42070eb25d
https://pubmed.ncbi.nlm.nih.gov/1359051

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Selective inhibitors of lecithin biosynthesis in mouse peritoneal macrophages

Autor: Philip Davies, R. J. Bonney, Paul D. Wightman

Publikováno v: Biochemical Pharmacology. 28:2471-2478

Mouse peritoneal macrophages turn over their membrane components rapidly. The biosynthetic pathway for phosphatidylcholine synthesis from choline can be inhibited in a non-toxic manner by a series of diphenylsulfones. The parent compound of this seri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ab31fe2bc5b22c7232b18e1c33457b7
https://doi.org/10.1016/0006-2952(79)90010-8

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