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Substituted 9-benzyladenines: Inhibitors of inflammation associated with the delayed hypersensitivity skin reaction

Publikováno v: Agents and Actions. 5:152-160

Members of a group of substituted 9-benzyladenines have been identified as effective inhibitors of inflammatory aspects of the delayed hypersensitivity skin reaction in the guinea-pig. Inhibitory activity was demonstrable in the efferent arc of the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1727de2324db47905fba49b62095cb2
https://doi.org/10.1007/bf02027357

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Rapid metabolic inactivation of tipredane, a structurally novel topical steroid

Autor: B. N. Lutsky, R. J. Wojnar, C. A. Free, L.M. Scanlan, J. Mitroka, B.H. Migdalof, S J Lan, R. C. Millonig, S.H. Weinstein

Publikováno v: Journal of Steroid Biochemistry. 31:825-834

[3H]Tipredane ([3H]TP), [3H]triamcinolone acetonide ([ 3H]TAAC), [3H]hydrocortisone ([3H]HC), and [3H]betamethasone-17 alpha-valerate ([3H]BMV), each at a concentration of 1 microM, were separately incubated with the 10,000 g supernatant fraction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62cc77d2d2a9831aa945b00b850a900e
https://doi.org/10.1016/0022-4731(88)90292-0

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Effect of analogs of cinanserin on human lymphocytes in vitro

Autor: S. M. Hess, D. V. Myers, R. J. Wojnar, R. C. Millonig, M. A. Spahn, S. Rahman

Publikováno v: Agents and Actions. 3:199-204

Cinanserin, 2′-(3-dimethylaminopropylthio)cinnamanilide, was compared in phytohemagglutinin (PHA)-treated human lymphocytes in vitro to two analogs, 2′-(3-dimethylaminopropoxy)-5′-methylcinnamanilide (SQ 11,276) and 5′-tert.-butyl-2′-(3-dim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43ba546d6e07e5f1b23164728bb03b6e
https://doi.org/10.1007/bf01968542

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Antiinflammatory activities of 2-acetyl- and 2-(1-hydroxyethyl)-4-[3-(dimethylamino)propyl]-3,4-dihydro-3-phenyl-2H-1,4-benzothiazine

Autor: E. Schulze, R. J. Wojnar, A. R. Turkheimer, W. F. Schreiber, R. C. Millonig, B. Rubin, W. E. Maguire, R. J. Brittain, M. B. Goldlust

Publikováno v: Journal of Medicinal Chemistry. 16:780-782

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952393da6e5d5ed1236b043f621c97cf
https://doi.org/10.1021/jm00265a008

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Characterization of augmentation of allergic and non-allergic histamine release by non-steroidal anti-inflammatory/analgesic agents

Autor: T. Hearn, R. J. Wojnar

Publikováno v: Agents and actions. 11(4)

Augmentation of allergic histamine release from human leukocytes previously was shown to be produced by numerous acidic anti-inflammatory/analgesic agents. In the present study, cicloprofen or diclofenac, representative of the arylalkanoic and anthra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa580fb81b8b22ce11f842c793e5da2
https://pubmed.ncbi.nlm.nih.gov/6169264

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Structure-activity profile of substituted purines and inflammation in the delayed hypersensitivity skin reaction

Autor: Kathryn A Losee, R. J. Brittain, R. J. Wojnar

Publikováno v: Agents and actions. 5(2)

Substituted purines were tested for their effectiveness in inhibiting the delayed hypersensitivity skin reaction (DHSR) caused by tuberculin in the guinea-pig. Among the tested purines were naturally occurring derivatives of guanine and adenine, incl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ecc356fcb5bd102ed31ba15dbcb72cb
https://pubmed.ncbi.nlm.nih.gov/1155302

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