Zobrazeno 1 - 10
of 27
pro vyhledávání: '"R J, Winquist"'
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(2)
We report on the development of a method for repeated monitoring of mucosal permeability that allows assessment of the severity of colitis and evaluation of treatment efficacy in HLA-B27 transgenic rats. We determined the extent to which intestinal p
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 287(2)
We investigated the contractile effects of both activated and unactivated polymorphonuclear leukocytes (PMNs) on human vascular tissue to characterize the influence of human PMNs on vascular tone. PMNs were added either unactivated or after f-met-leu
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 272(1)
NG-nitro-L-arginine methyl ester (L-NAME) has been reported to have variable effects on the vasodilator response to acetylcholine (ACh) and bradykinin (BK) in vivo. Whether administration of L-NAME affects mean arterial pressure (MAP) or heart rate (
Effects of losartan (DuP753) and enalaprilat on the mean arterial pressure response to phenylephrine
Autor:
J B, Madwed, R J, Winquist
Publikováno v:
Journal of hypertension. 12(2)
We have found that low-dose infusion of angiotensin II (Ang II) selectively potentiates the mean arterial pressure (MAP) response to phenylephrine in pentobarbital-anesthetized rabbits.To examine whether endogenous Ang II levels in normotensive rabbi
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 263(3)
The renal vascular effects of serotonin (5-HT) in vivo vary among preparations, which may reflect that this autacoid can modulate the vascular response to certain spasmogens. We investigated this phenomenon in the isolated rabbit kidney perfused unde
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 261(3)
Experiments were performed to investigate the vascular reactivity in both large and resistance artery preparations from an animal model of septic shock. New Zealand White rabbits were injected with a priming dose of Escherichia coli lipopolysaccharid
Autor:
M L, Garcia, V F, King, J L, Shevell, R S, Slaughter, G, Suarez-Kurtz, R J, Winquist, G J, Kaczorowski
Publikováno v:
The Journal of biological chemistry. 265(7)
Three structural classes of commonly used amiloride analogs, molecules derivatized at the terminal guanidino-nitrogen, the five-position pyrazinoyl-nitrogen, or di-substituted at both of these positions, inhibit binding of the L-type Ca2+ channel mod
Autor:
L W, Schaffer, T W, Schorn, R J, Winquist, J F, Strouse, L, Payne, P K, Chakravarty, S E, de Laszlo, J, tenBroeke, D F, Veber, W J, Greenlee
Publikováno v:
Journal of hypertension. 8(3)
In order to investigate the hypotensive mechanisms of action of peptide renin inhibitors, blood pressure responses to five renin inhibitors were compared with those to the angiotensin converting enzyme inhibitor, enalaprilat, in conscious African gre
Publikováno v:
Circulation Research. 51:769-776
The large arteries at the base of the brain in the pig were studied in vitro for their responsiveness to neurogenic and humoral stimuli. Helical strips of these cerebral vessels tonically contracted consistently following application of resting force
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 241:H211-H216
The effects of lead on vascular responsiveness were examined in rats. Adult rats, which had received levels of lead acetate in their drinking water to produce blood levels similar to those seen in some urban human populations, consistently had higher