Zobrazeno 1 - 10
of 29
pro vyhledávání: '"R J, Vavrek"'
Publikováno v:
Archives of Dermatological Research. 284:1-4
Bradykinin has long been postulated to have a major role in physiologic human pain production. We have developed a method to systematically quantify the algogenic response to bradykinin in human skin by the direct application of bradykinin to suction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015f9692e8ee0b40920967e562b8b214
https://doi.org/10.1007/bf00371917
https://doi.org/10.1007/bf00371917
Publikováno v:
American Journal of Physiology-Renal Physiology. 258:F643-F648
We contrasted the effects of D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-DPhe-Thi-Arg-TFA (kinin receptor antagonist), of aprotinin (kallikrein inhibitor), and of combined treatment with captopril (kininase II inhibitor) and phosphoramidon (neutral endopeptidase 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c692b87533fa1a0281b93937c5a05442
https://doi.org/10.1152/ajprenal.1990.258.3.f643
https://doi.org/10.1152/ajprenal.1990.258.3.f643
Publikováno v:
Circulation Research. 66:234-240
We examined the relative contribution of renin-angiotensin system blockade and bradykinin potentiation to the renal hemodynamic effect of the angiotensin converting enzyme inhibitor enalaprilat in sodium-deprived dogs. Six conscious dogs instrumented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbfd210301710dc98467312ee36b57a9
https://doi.org/10.1161/01.res.66.1.234
https://doi.org/10.1161/01.res.66.1.234
Publikováno v:
Agents and actions. Supplements. 38
Over 100 reduced-bond analogs of bradykinin and bradykinin antagonists were designed, synthesized, and assayed in the classic smooth muscle and blood pressure assays in a further study of the structure-activity relationships of bradykinin. Both poten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d2fd84c9fecfe4888620cee9bae486c
https://pubmed.ncbi.nlm.nih.gov/1466297
https://pubmed.ncbi.nlm.nih.gov/1466297
Publikováno v:
Agents and actions. Supplements. 38
More than 200 new analogs of bradykinin have been synthesized and assayed. Analogs containing a D-aliphatic amino acid residue at position 7 and an L-aliphatic residue at position 8 are very potent antagonists of BK action on classical systems. Thus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62b2f01ffe418af8fd5d3284c966f992
https://pubmed.ncbi.nlm.nih.gov/1466298
https://pubmed.ncbi.nlm.nih.gov/1466298
Publikováno v:
Agents and actions. Supplements. 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b4643a8af8533abe6537dad85c2ef29
https://pubmed.ncbi.nlm.nih.gov/1334330
https://pubmed.ncbi.nlm.nih.gov/1334330
Autor:
J M, Stewart, R J, Vavrek
Publikováno v:
Journal of cardiovascular pharmacology. 15
Bradykinin antagonists effective in a great variety of kinin-responsive tissues have been developed and used to study the roles of kinins in various physiological and pathological phenomena. Structural changes required to yield antagonists and to con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eca59e6c503e6fc012476a9edb6d1270
https://pubmed.ncbi.nlm.nih.gov/1697364
https://pubmed.ncbi.nlm.nih.gov/1697364
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 336:430-433
A range of bradykinin (BK) analogues was assessed for their ability to antagonise the action of BK on rabbit jugular vein, a B2-receptor containing tissue, and compared with their action against BK-induced increases in skin vascular permeability in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5090daf95ebee003d8f09f20cd58e346
https://doi.org/10.1007/bf00164878
https://doi.org/10.1007/bf00164878
Publikováno v:
Hypertension. 8:971-974
This study was designed to examine the contribution of bradykinin to the depressor effect of different antihypertensive drugs in two-kidney renovascular hypertensive rats, using a new specific antagonist of bradykinin. First, the inhibitory capacity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e211c44d298fee136a9a247c7468d49
https://doi.org/10.1161/01.hyp.8.11.971
https://doi.org/10.1161/01.hyp.8.11.971
Publikováno v:
Stroke. 18:792-795
We have previously shown that topical brain application of kallikrein, an enzyme which converts kininogen to bradykinin, induces rabbit pial arteriole dilation. The purpose of the present investigation was to utilize a newly developed competitive kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68bcf51b3ebf8a89e2ff8f2dcd1b3acb
https://doi.org/10.1161/01.str.18.4.792
https://doi.org/10.1161/01.str.18.4.792