Architecture of a-Crystallin: Surface Probing by Limited Proteolysis

Autor: R. J. Siezen, H. J. Hoenders

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f45061de44aa8102bc397dfb5b075cbd
https://doi.org/10.1159/000401940

Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis

Autor: Torik A.Y. Ayoubi, R. J. Siezen, W.J.M. Van de Ven, A. J. M. Roebroek, John W.M. Creemers, Danny Huylebroeck

Publikováno v: Journal of Biological Chemistry. 268:21826-21834

The proprotein processing activity of mutants of the subtilisin-like enzyme furin was studied in transfected mammalian cells. Our studies indicate that the three residues of the catalytic triad of furin, Asp46, His87, and Ser261, are critical not onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c6a4ff1195dabbe8063346a73a0b2e5
https://doi.org/10.1016/s0021-9258(20)80616-4

Lactic acid bacteria: genetics, metabolism and applications

Autor: R. J. Siezen, T. Abee, G. Schaafsma, Jan Kok

Publikováno v: Lactic Acid Bacteria: Genetics, Metabolism and Applications ISBN: 9789048161416
Lactic Acid Bacteria: Genetics, Metabolism and Applications

Foods fermented with Lactic Acid Bacteria are an important part of the human diet. Lactic Acid Bacteria play an essential role in the preservation of foods and contribute to the nutritional, sensoric and health properties of food products and animal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::814399ddb63c5f754ebef933f7f0636c
https://doi.org/10.1007/978-94-017-2029-8_1

Subtilases: the superfamily of subtilisin-like serine proteases

Autor: R J, Siezen, J A, Leunissen

Publikováno v: Protein science : a publication of the Protein Society. 6(3)

Subtilases are members of the clan (or superfamily) of subtilisin-like serine proteases. Over 200 subtilases are presently known, more than 170 of which with their complete amino acid sequence. In this update of our previous overview (Siezen RJ, de V

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1d8fec3cadf882b36fa2214754de66be
https://pubmed.ncbi.nlm.nih.gov/9070434

Modelling and engineering of enzyme/substrate interactions in subtilisin-like enzymes of unknown 3-dimensional structure

Autor: R J, Siezen

Publikováno v: Advances in experimental medicine and biology. 379

Homology modelling was used to predict enzyme-substrate interactions in three entirely different subtilisin-like enzymes of unknown three-dimensional structure. i.e. (a) cell-envelope proteinase of Lactococcus lactis, (b) putative leader peptidase fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5869300547c280022c1e460c90fea403
https://pubmed.ncbi.nlm.nih.gov/8796311