Zobrazeno 1 - 10
of 55
pro vyhledávání: '"R J, Shearer"'
Autor:
Douglas F. Easton, Richard S. Houlston, David P. Dearnaley, Zstotia Kote-Jarai, Ros Eeles, Rashmi Singh, Roger Kirby, A Murkin, S M Edwards, Ruchel A. Jackson, Francine Durocher, Audrey Ardern-Jones, Sarah Jefferies, R. J. Shearer
Publikováno v:
Pharmacogenetics. 11:325-330
There is evidence suggesting that polymorphic variations in the glutathione S-transferases (GSTs) are associated with cancer susceptibility. Inter-individual differences in cancer susceptibility may be mediated in part through polymorphic variability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7abeef2f67727d19d91cf5b1c65b8b65
https://doi.org/10.1097/00008571-200106000-00007
https://doi.org/10.1097/00008571-200106000-00007
Androgen receptor polymorphisms: Association with prostate cancer risk, relapse and overall survival
Autor:
Stephen M. Edwards, Rosalind A. Eeles, A Dowe, Simon Osborne, J. Kelly, R. J. Shearer, Doug Easton, Audrey Ardern-Jones, Ralph Minter, N. Collins, Mike Badzioch, Rifat Hamoudi, David P. Dearnaley, Grady F. Saunders
Publikováno v:
International Journal of Cancer. 84:458-465
Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)ncoding for polyglycine, may be associated with prostate cancer risk; but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb2c3b483c09f1c8cdc193e233934c5
https://doi.org/10.1002/(sici)1097-0215(19991022)84:5<458::aid-ijc2>3.0.co
https://doi.org/10.1002/(sici)1097-0215(19991022)84:5<458::aid-ijc2>3.0.co
Autor:
Sandra Gill, A Dowe, Steve Edwards, Rosalind A. Eeles, Terri M. King, Armen Aprikian, Audrey Ardern-Jones, Fernand Labrie, Christopher I. Amos, D Ford, Rifat Hamoudi, Douglas F. Easton, R. J. Shearer, Parviz Ghadirian, Dawn L. McLennan, Mike Badzioch, Francine Durocher, Dawn Teare, Patrick J. Biggs, Richard Norman, Steven A. Narod, David P. Dearnaley, Jacques Simard, William D. Foulkes
Publikováno v:
The American Journal of Human Genetics. 62:653-658
SummaryProstate cancer shows evidence of familial aggregation, particularly at young ages at diagnosis, but the inherited basis of familial prostate cancer is poorly understood. Smith et al. recently found evidence of linkage to markers on 1q, at a l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370f495ff874c2360f4d34b497d6073b
https://doi.org/10.1086/301745
https://doi.org/10.1086/301745
Autor:
Doug Easton, Audrey Ardern-Jones, Rifat Hamoudi, A Dowe, Stephen M. Edwards, D Ford, David P. Dearnaley, Rosalind A. Eeles, R. J. Shearer
Publikováno v:
British Journal of Cancer. 76:992-1000
There is evidence that predisposition to cancer has a genetic component. Genetic models have suggested that there is at least one highly penetrant gene predisposing to this disease. The oncogene MXI1 on chromosome band 10q24-25 is mutated in a propor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b2f6b757cd44801e9481b852dff42ef
https://doi.org/10.1038/bjc.1997.498
https://doi.org/10.1038/bjc.1997.498
Publikováno v:
British Journal of Urology. 76:77-80
Objective To determine the proportion of patients with symptoms of urinary outflow obstruction secondary to benign prostatic hyperplasia (BPH) who could be managed in the community after assessment in a shared-care clinic (managed by nursing staff, s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ca31eb0a7a022157d5af91f2bae0f8
https://doi.org/10.1111/j.1464-410x.1995.tb07836.x
https://doi.org/10.1111/j.1464-410x.1995.tb07836.x
Autor:
Michael B. Sporn, Anthony A. Colletta, KC Flanders, Cyril Fisher, G.H. Muir, David P. Dearnaley, A Butta, R. J. Shearer
Publikováno v:
British Journal of Cancer
Transforming growth factor beta-1 (TGF-beta 1) has been proposed as a mediator of tumour growth in a number of tumours and cell lines including prostate, and in a recent study was shown to be up-regulated in the stroma of breast cancer tissue followi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f176250b7021be05908d137fcc39a7d6
http://europepmc.org/articles/PMC1968789
http://europepmc.org/articles/PMC1968789
Autor:
Michael R. Stratton, Rosalind A. Eeles, A. Price, J Melia, G Muir, David P. Dearnaley, Michael Jarman, J Chamberlain, R. J. Shearer
Publikováno v:
The Lancet. 342:901-905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9b71b9def6793126573f5db922b2348
https://doi.org/10.1016/0140-6736(93)91949-m
https://doi.org/10.1016/0140-6736(93)91949-m
Publikováno v:
British Journal of Urology. 71:583-586
Summary— Thirty-one patients with retention of urine and carcinoma of the prostate were treated with LHRH analogues as primary therapy rather than prostatectomy; 21 patients voided without the need for surgical intervention. Patients presenting in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74749e8893a54e41b8a21a976f4eb0f1
https://doi.org/10.1111/j.1464-410x.1993.tb16029.x
https://doi.org/10.1111/j.1464-410x.1993.tb16029.x
Autor:
G.K. Poon, Michael Jarman, John Houghton, Martin G. Rowlands, J. H. Davies, Mitch Dowsett, R. J. Shearer
Publikováno v:
Journal of Enzyme Inhibition. 6:141-147
The steroidal aromatase inhibitor, 4-hydroxyandrost-4-ene-3,17-dione (4OHA) and its metabolites, 4-hydroxytestosterone (4OHT), 3 beta,17-dihydroxy-5 alpha-androstan-4-one (metabolite A) and 3 alpha, 17-dihydroxy-5 beta-androstan-4-one (metabolite B)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ff109bc22b4a66103d2c03b0cdb2b7
https://doi.org/10.3109/14756369209040745
https://doi.org/10.3109/14756369209040745
Publikováno v:
Journal of Enzyme Inhibition. 4:307-313
The aromatase enzyme was quantified by the release of tritiated water from [1 beta-3H] androstenedione. Tritiated water was released by the crude homogenates in 4 of 18 samples of benign prostatic hyperplasia tissue and one of 5 samples of prostate c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95d5b265963669a57bd3926f85531f47
https://doi.org/10.3109/14756369109030395
https://doi.org/10.3109/14756369109030395