Zobrazeno 1 - 10
of 66
pro vyhledávání: '"R J, Robb"'
Autor:
R J Robb, Hank Ja, Mitsuru Tsudo, Gilda Weil-Hillman, Stephan D. Voss, Kazuo Sugamura, Paul M. Sondel
Publikováno v:
The Journal of Experimental Medicine
The expression of the 70-kD beta subunit of the interleukin 2 receptor (IL-2R) has been examined on peripheral blood lymphocytes (PBL) obtained from patients receiving systemic infusions of IL-2. Using monoclonal antibodies directed against p70, flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::971f759613d3433c5dd8a6bdc0b81140
https://doi.org/10.1084/jem.172.4.1101
https://doi.org/10.1084/jem.172.4.1101
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 160(8)
We developed a liposome carrier for a model nonimmunogenic, self Ag. This carrier reproducibly converted lymphoma Ig into a potent tumor rejection Ag in mice. A single immunization induced protection against challenges representing 20 to 100 times th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::53c2a94df88452298a540be0cd721f72
https://pubmed.ncbi.nlm.nih.gov/9558062
https://pubmed.ncbi.nlm.nih.gov/9558062
The interleukin 2 receptor (IL-2R) consists of at least two subunits, alpha and beta, both of which can bind interleukin 2 (IL-2). Recent studies have demonstrated the existence of a third subunit, a 64-kDa molecule termed IL-2R gamma chain, and have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb165514fdeb9cdd19fa3d2b931a8fc9
https://europepmc.org/articles/PMC46100/
https://europepmc.org/articles/PMC46100/
Publikováno v:
The Journal of Experimental Medicine
Interleukin 2 (IL-2) receptors expressed on the surface of activated T cells and natural killer (NK) cells exhibit a variety of affinity states depending on their subunit composition. Low-affinity binding is associated with a 55-kDa alpha chain, inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca3bea27dfd2a8871a68f31bbd02d88
https://pubmed.ncbi.nlm.nih.gov/1500859
https://pubmed.ncbi.nlm.nih.gov/1500859
Autor:
A, Heguy, C, Baldari, K, Bush, R, Nagele, R C, Newton, R J, Robb, R, Horuk, J L, Telford, M, Melli
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 2(7)
The human fibroblast interleukin 1 (IL-1) receptor is a glycosylated transmembrane protein with a cytoplasmic domain of 213 amino acids. We have constructed a series of deletion mutants of the cytoplasmic region of the IL 1 receptor and have used the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::544788d1b79bb23b68897c017cf2d8e7
https://pubmed.ncbi.nlm.nih.gov/1664234
https://pubmed.ncbi.nlm.nih.gov/1664234
Publikováno v:
Lymphokine and cytokine research. 10(3)
The interleukin 2 receptor is a multisubunit receptor known to consist of at least two IL-2 binding subunits, alpha and beta. We report here kinetic evidence defining the contribution of an affinity-modulating element(s) intimately involved in modula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d454e614ef62145ec56d114ce6301422
https://pubmed.ncbi.nlm.nih.gov/1883916
https://pubmed.ncbi.nlm.nih.gov/1883916
Autor:
B D, Freimark, R J, Robb
Publikováno v:
Lymphokine research. 9(4)
Full length cDNAs encoding the human and murine p70 genes were isolated using polymerase chain reaction (PCR) and conventional cDNA library screening techniques, respectively. To validate their functional potential, expression vectors containing huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b2fa6038e1b79e758263ad4b362f33a
https://pubmed.ncbi.nlm.nih.gov/2090877
https://pubmed.ncbi.nlm.nih.gov/2090877
Publikováno v:
The Journal of Immunology. 139:855-862
The Tac protein is one of at least two glycoproteins known to bind the growth and differentiation factor interleukin 2 (IL 2). In addition to its location on the cell surface, where it plays a part in high and low affinity IL 2 receptors, Tac is rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::609e2248f9a183ed5555b2209b4ae8ea
https://doi.org/10.4049/jimmunol.139.3.855
https://doi.org/10.4049/jimmunol.139.3.855
Autor:
R. J. Robb, Debra J. Wilson, Elizabeth A. Grimm, Jack A. Roth, Steven A. Rosenberg, L. M. Neckers, L. B. Lachman
Publikováno v:
The Journal of Experimental Medicine
Purified interleukin 2 (IL-2) was found to be sufficient for direct activation of peripheral blood lymphocytes into lymphokine-activated killer (LAK) cells. The LAK activation factor was directly and consistently associated with IL-2 activity using c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b427572a05506b6a3a36f9123b48eb5f
http://europepmc.org/articles/PMC2187385
http://europepmc.org/articles/PMC2187385
Publikováno v:
The Journal of Immunology. 140:2249-2259
IL-2R on activated lymphocytes contain the Tac protein. As part of an effort to characterize this molecule, we examined the structure-activity relationship for each of its 12 Cys residues. A preliminary map of intramolecular disulfide bonding was der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ebe6c12954b220af95b5724f27befc
https://doi.org/10.4049/jimmunol.140.7.2249
https://doi.org/10.4049/jimmunol.140.7.2249