Výsledky vyhledávání - "R J, Lefkowitz"

Elektronická kniha

Autor: R. J. Lefkowitz

ROBERT J. LEFKOWITZ, M. D. Receptor Regulation (Receptors and Recognition, Series B, Volume 13) Edited by R. J. Lefkowitz Published in 1981 by Chapman and Hall, 11 New Fetter Lane, London EC4P 4EE © 1981 Chapman and Hall The study of hormone and dru

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Royal academy of medicine in Ireland section of surgery

Publikováno v: Irish Journal of Medical Science. 167:253-255

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a323c89ecf0010935b834db82e6e066
https://doi.org/10.1007/bf02937425

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Beta-Arrestins: new roles in regulating heptahelical receptors' functions

Autor: P H, McDonald, R J, Lefkowitz

Publikováno v: Cellular signalling. 13(10)

The last few years have seen a marked expansion in appreciation of the diversity of roles played by the betaArrestins in regulating GPCR functions. Originally discovered as molecules that desensitize such receptors, the roles of betaArrestins have ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bb459d3b339412c515051e40c18dbaf1
https://pubmed.ncbi.nlm.nih.gov/11602178

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Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding

Autor: K L, Pierce, A, Tohgo, S, Ahn, M E, Field, L M, Luttrell, R J, Lefkowitz

Publikováno v: The Journal of biological chemistry. 276(25)

"Transactivation" of epidermal growth factor receptors (EGFRs) in response to activation of many G protein-coupled receptors (GPCRs) involves autocrine/paracrine shedding of heparin-binding EGF (HB-EGF). HB-EGF shedding involves proteolytic cleavage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b55a94c4307167f556ee7fb8ab39e592
https://pubmed.ncbi.nlm.nih.gov/11290747

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beta-arrestin1 interacts with the catalytic domain of the tyrosine kinase c-SRC. Role of beta-arrestin1-dependent targeting of c-SRC in receptor endocytosis

Autor: W E, Miller, S, Maudsley, S, Ahn, K D, Khan, L M, Luttrell, R J, Lefkowitz

Publikováno v: The Journal of biological chemistry. 275(15)

beta-Arrestins can act as adapter molecules, coupling G-protein-coupled receptors to proteins involved in mitogenic as well as endocytic pathways. We have previously identified c-SRC as a molecule that is rapidly recruited to the beta2-adrenergic rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68035cff2ab2efb7c77c56676f063aa5
https://pubmed.ncbi.nlm.nih.gov/10753943

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beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors

Autor: L A, Hu, Y, Tang, W E, Miller, M, Cong, A G, Lau, R J, Lefkowitz, R A, Hall

Publikováno v: The Journal of biological chemistry. 275(49)

The beta(1)-adrenergic receptor (beta(1)AR) is the most abundant subtype of beta-adrenergic receptor in the mammalian brain and is known to potently regulate synaptic plasticity. To search for potential neuronal beta(1)AR-interacting proteins, we scr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9e1e1f21dd85c52dc7b240ab2e742a91
https://pubmed.ncbi.nlm.nih.gov/10995758

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The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing

Autor: R T, Premont, A, Claing, N, Vitale, S J, Perry, R J, Lefkowitz

Publikováno v: The Journal of biological chemistry. 275(29)

We recently characterized a novel protein, GIT1, that interacts with G protein-coupled receptor kinases and possesses ADP-ribosylation factor (ARF) GTPase-activating protein activity. A second ubiquitously expressed member of the GIT protein family,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0ddd7abfa5550ef63b8ae381b858b4fb
https://pubmed.ncbi.nlm.nih.gov/10896954

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The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation

Autor: R T, Premont, A D, Macrae, S A, Aparicio, H E, Kendall, J E, Welch, R J, Lefkowitz

Publikováno v: The Journal of biological chemistry. 274(41)

G protein-coupled receptor kinases (GRKs) desensitize G protein-coupled receptors by phosphorylating activated receptors. The six known GRKs have been classified into three subfamilies based on sequence and functional similarities. Examination of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e3f3043e41bfa128cf63f4af1a294ac4
https://pubmed.ncbi.nlm.nih.gov/10506199

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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases

Autor: G J, Della Rocca, S, Maudsley, Y, Daaka, R J, Lefkowitz, L M, Luttrell

Publikováno v: The Journal of biological chemistry. 274(20)

G protein-coupled receptors (GPCRs) initiate Ras-dependent activation of the Erk 1/2 mitogen-activated protein kinase cascade by stimulating recruitment of Ras guanine nucleotide exchange factors to the plasma membrane. Both integrin-based focal adhe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::30b41453a1b88da14b60a062e713c87d
https://pubmed.ncbi.nlm.nih.gov/10318809

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Identification of NSF as a beta-arrestin1-binding protein. Implications for beta2-adrenergic receptor regulation

Autor: P H, McDonald, N L, Cote, F T, Lin, R T, Premont, J A, Pitcher, R J, Lefkowitz

Publikováno v: The Journal of biological chemistry. 274(16)

Previous studies have demonstrated that beta-arrestin1 serves to target G protein-coupled receptors for internalization via clathrin-coated pits and that its endocytic function is regulated by dephosphorylation at the plasma membrane. Using the yeast

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fcfd441f1d2e699677addf8af2411dc2
https://pubmed.ncbi.nlm.nih.gov/10196135

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