Zobrazeno 1 - 10
of 16
pro vyhledávání: '"R J, Hohl"'
Autor:
R J, Hohl
Publikováno v:
Clinical pharmacology and therapeutics. 97(5)
Autor:
J E, Rosenberg, S, Halabi, B L, Sanford, A L, Himelstein, J N, Atkins, R J, Hohl, F, Millard, D F, Bajorin, E J, Small, Nancy, Bartlett
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 19(5)
There is no standard second-line treatment for advanced urothelial carcinoma (UC). Response rates to second-line chemotherapy for advanced UC are low and response duration is short. Bortezomib is a proteasome inhibitor with preclinical activity again
Autor:
S A, Holstein, R J, Hohl
Publikováno v:
Molecular cancer therapeutics. 1(2)
The hydroxymethylglutaryl-CoA reductase inhibitor lovastatin is used widely to treat hypercholesterolemia and has been shown to have cell cycle-specific effects. In these studies, we have examined the effects of combining lovastatin and paclitaxel (T
Autor:
C P, Burns, S, Halabi, G H, Clamon, V, Hars, B A, Wagner, R J, Hohl, E, Lester, J J, Kirshner, V, Vinciguerra, E, Paskett
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 5(12)
The purpose of this study was to determine the maximum tolerated dose and dose-limiting toxicities of fish oil fatty acid capsules containing omega-3 fatty acid ethyl esters. Twenty-two patients with neoplastic disease not amenable to curative therap
Publikováno v:
American journal of hematology. 59(3)
Unexpectedly low hemoglobin oxygen saturation as determined by pulse-oximeter analysis was observed in a patient who underwent an elective surgical procedure. Specific hemoglobin derivatives such as carboxyhemoglobin, methemoglobin, and reduced hemog
Publikováno v:
Blood. 88(12)
Lovastatin, a cholesterol-lowering drug, has antiproliferative properties that may be related to its inhibition of protein isoprenylation. We examined the effects of lovastatin on signal transduction via the T-cell antigen receptor (TCR). Lovastatin
Publikováno v:
Bone marrow transplantation. 18(3)
Acute decompensating cardiomyopathy induced by cyclophosphamide is usually irreversible. To investigate the clinical course and the outcome of therapy, 13 patients (1.7%) with grade III acute cardiomyopathy and hypotension who were treated with ablat
Autor:
A, Thibault, D, Samid, A C, Tompkins, W D, Figg, M R, Cooper, R J, Hohl, J, Trepel, B, Liang, N, Patronas, D J, Venzon, E, Reed, C E, Myers
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(3)
Lovastatin, an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (the major regulatory enzyme of the mevalonate pathway of cholesterol synthesis), displays antitumor activity in experimental models. We therefore conducted a Phas
Autor:
R J, Hohl
Publikováno v:
Advances in experimental medicine and biology. 401
Limonene and related monoterpenes display compelling anticarcinogenic activity. The mechanism(s) that underline this activity is/are as yet unknown. One attractive possibility is that the monoterpenes interact with the RAS signal transduction pathway
Publikováno v:
Bone marrow transplantation. 16(1)
Reproducible and characteristic clinical findings of fever, skin rash, capillary leak and pulmonary infiltrates have been observed during engraftment in patients with autologous bone marrow (BM) and/or peripheral stem cell transplantation (PSCT). Two