Zobrazeno 1 - 10
of 13
pro vyhledávání: '"R J, Debs"'
Publikováno v:
Gene Therapy. 13:1724-1730
Depsipeptide, a histone deacetylase (HDAC) inhibitor, kills tumor cells much more effectively than normal cells, and can produce significant antitumor activity in human cancer patients. Depsipeptide also increases the expression of lipoplex-delivered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed2de830aafa51250f8a47ec2dcd40f
https://doi.org/10.1038/sj.gt.3302825
https://doi.org/10.1038/sj.gt.3302825
Publikováno v:
Infection and Immunity. 59:3859-3862
Pneumocystis carinii pneumonia in patients with AIDS may result from impaired local release of gamma interferon from lung lymphocytes and subsequent failure of macrophage activation. We tested this hypothesis with mice rendered immunodeficient by sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc973b940bd5633b65327e3c1e8a2a6
https://doi.org/10.1128/iai.59.11.3859-3862.1991
https://doi.org/10.1128/iai.59.11.3859-3862.1991
Publikováno v:
The Journal of biological chemistry. 265(18)
We describe a procedure for assessing the functional activity in vivo of a glucocorticoid receptor derivative, T7X556, a mammalian transcriptional regulator that has been overexpressed in Escherichia coli and purified to homogeneity. The protein was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61ecc69af415b5e8a4a6e95fa0ef6933
https://pubmed.ncbi.nlm.nih.gov/2354996
https://pubmed.ncbi.nlm.nih.gov/2354996
Autor:
R J, Debs, H J, Fuchs, R, Philip, E N, Brunette, N, Düzgüneş, J E, Shellito, D, Liggitt, J R, Patton
Publikováno v:
Cancer research. 50(2)
Tumor necrosis factor alpha has potent immunomodulatory and antitumor activity, but its therapeutic applications may be limited by its significant host toxicity. We showed that liposome-encapsulated recombinant human tumor necrosis factor alpha (rHuT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8e0c67d59bd82e06e44862526201407
https://pubmed.ncbi.nlm.nih.gov/2295077
https://pubmed.ncbi.nlm.nih.gov/2295077
Autor:
R J Debs, H J Fuchs, R Philip, A B Montgomery, E N Brunette, D Liggitt, J S Patton, J E Shellito
Publikováno v:
The Journal of Immunology. 140:3482-3488
The recombinant cytokines IFN-gamma and TNF-alpha stimulate several macrophage-mediated functions important in host defense. However, systemic administration of cytokines may be limited by significant host toxicity. We investigated whether aerosolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e57ef3263d071007ee39c8c377917196
https://doi.org/10.4049/jimmunol.140.10.3482
https://doi.org/10.4049/jimmunol.140.10.3482
Publikováno v:
Infection and Immunity. 57:132-137
In this study we compared the ability of free- and liposome-incorporated murine recombinant gamma interferon (rIFN-gamma) to enhance peritoneal macrophage H2O2 release and antitoxoplasma activity in vitro. rIFN-gamma was efficiently (37 to 47%) incor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5567be8ab37dd2e302d15ac24c14ac4a
https://doi.org/10.1128/iai.57.1.132-137.1989
https://doi.org/10.1128/iai.57.1.132-137.1989
Publikováno v:
The Journal of Immunology. 143:1192-1197
Cell-associated TNF-alpha, either bound to its receptor on monocyte membranes or expressed as an integral membrane protein, can exert potent tumor cytolytic activity. We assessed the interaction of TNF with the lipid bilayer membrane system, liposome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::09d24b6bf26344eb8a5e5a088b6ddc65
https://doi.org/10.4049/jimmunol.143.4.1192
https://doi.org/10.4049/jimmunol.143.4.1192
Publikováno v:
Cancer research. 48(18)
Liposomes containing cytotoxic agents may be highly efficacious for intracavitary therapy of malignancies such as ovarian carcinoma, which resides principally in the peritoneal cavity. We have examined in vitro the cytotoxicity of a variety of liposo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61a364bc8eb0252ab807efce2fb19ff0
https://pubmed.ncbi.nlm.nih.gov/3409248
https://pubmed.ncbi.nlm.nih.gov/3409248
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 143(4)
Cell-associated TNF-alpha, either bound to its receptor on monocyte membranes or expressed as an integral membrane protein, can exert potent tumor cytolytic activity. We assessed the interaction of TNF with the lipid bilayer membrane system, liposome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4852415acdcbefaf138e360c736ebac8
https://pubmed.ncbi.nlm.nih.gov/2787358
https://pubmed.ncbi.nlm.nih.gov/2787358
Autor:
R J, Debs, H J, Fuchs, R, Philip, A B, Montgomery, E N, Brunette, D, Liggitt, J S, Patton, J E, Shellito
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 140(10)
The recombinant cytokines IFN-gamma and TNF-alpha stimulate several macrophage-mediated functions important in host defense. However, systemic administration of cytokines may be limited by significant host toxicity. We investigated whether aerosolize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::998e495458a75564ba213971bced6f59
https://pubmed.ncbi.nlm.nih.gov/3283235
https://pubmed.ncbi.nlm.nih.gov/3283235