Zobrazeno 1 - 10
of 46
pro vyhledávání: '"R J, Dearman"'
Publikováno v:
Journal of applied toxicology : JAT. 33(7)
Although allergic sensitization of the respiratory tract induced by chemicals is not as common as skin sensitization, it is nevertheless an important occupational health issue. Respiratory allergy to chemicals, characterized typically by rhinitis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cae0af8f28e12f0e390b1ef1a3173a7c
https://pubmed.ncbi.nlm.nih.gov/22271251
https://pubmed.ncbi.nlm.nih.gov/22271251
Publikováno v:
The British Journal of Dermatology
Background With increasing age the immune system shows functional decline. In the skin this is associated with an increased incidence of epidermal malignancies and infections. Epidermal Langerhans cells (LCs) act as sentinels of the immune system, re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38ed7d4a155ffc14173e43f490430cce
https://pubmed.ncbi.nlm.nih.gov/21410677
https://pubmed.ncbi.nlm.nih.gov/21410677
Publikováno v:
Methods in molecular medicine. 64
The skin is an immunologically active tissue; the integrated skin immune system comprises epidermal Langerhans cells (LC), dermal dendritic cells (DC), tissue macrophages, mast cells, and T lymphocytes in transit. Cutaneous immune function is orchest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7d70f757a8a257fbea533e875a522291
https://pubmed.ncbi.nlm.nih.gov/21374273
https://pubmed.ncbi.nlm.nih.gov/21374273
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 41(3)
One explanation for the striking increase in atopic disease in developed countries over the last 50 years has been the 'Hygiene Hypothesis'; a reduced exposure to pathogenic microorganisms. We have postulated previously that oral and cutaneous exposu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42cb06b8b18c8d21e87464005eff8e05
https://pubmed.ncbi.nlm.nih.gov/21255157
https://pubmed.ncbi.nlm.nih.gov/21255157
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 33(11)
With the increasing interest in novel foods derived from transgenic crop plants, there is a growing need for the development of approaches for the characterization of the allergenic potential of proteins. Whereas immunogenicity is a common property o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::92c4a55ed8a337bef3c1674f6e3e138f
https://pubmed.ncbi.nlm.nih.gov/14616873
https://pubmed.ncbi.nlm.nih.gov/14616873
Publikováno v:
Humanexperimental toxicology. 22(8)
During the last 10 years there have been several attempts to define criteria for the integration of experimental and clinical data into schemes that can be used for the designation of chemicals as skin sensitizers (and in some instances respiratory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4b22af7df79e9157def2c6f6f1f51885
https://pubmed.ncbi.nlm.nih.gov/15901055
https://pubmed.ncbi.nlm.nih.gov/15901055
Autor:
L M, Hamilton, C, Torres-Lozano, S M, Puddicombe, A, Richter, I, Kimber, R J, Dearman, B, Vrugt, R, Aalbers, S T, Holgate, R, Djukanović, S J, Wilson, D E, Davies
Publikováno v:
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 33(2)
The extent of epithelial injury in asthma is reflected by expression of the epidermal growth factor receptor (EGFR), which is increased in proportion to disease severity and is corticosteroid refractory. Although the EGFR is involved in epithelial gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02c719b9ddfc44091b8c698dc5a9e5bd
https://pubmed.ncbi.nlm.nih.gov/12580917
https://pubmed.ncbi.nlm.nih.gov/12580917
Publikováno v:
Contact dermatitis. 47(6)
The local lymph node assay (LLNA) was developed originally as a method for the identification of chemicals that have the potential to cause skin sensitization and allergic contact dermatitis. The assay is based on an understanding that the acquisitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9630181b4afd6e8d039b6579c236f0f7
https://pubmed.ncbi.nlm.nih.gov/12581276
https://pubmed.ncbi.nlm.nih.gov/12581276
Publikováno v:
The British journal of dermatology. 146(1)
Langerhans cells (LCs) play essential roles in the initiation and regulation of cutaneous immune responses mediated through their successful migration from the epidermis to draining lymph nodes while carrying antigen. Tumour necrosis factor (TNF)-alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41a0c02173eae14d60a4ac88b73b83e5
https://pubmed.ncbi.nlm.nih.gov/12452893
https://pubmed.ncbi.nlm.nih.gov/12452893
Publikováno v:
Current opinion in drug discoverydevelopment. 4(1)
The mouse local lymph node assay (LLNA) is currently used for the prospective identification of chemicals that have the potential to cause skin sensitization and allergic contact dermatitis. In this respect, the assay has been fully and formally eval
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa1e1951b027d17268cba7dd9ebed3cc
https://pubmed.ncbi.nlm.nih.gov/11727324
https://pubmed.ncbi.nlm.nih.gov/11727324