Zobrazeno 1 - 10
of 18
pro vyhledávání: '"R J, Cristiano"'
Publikováno v:
Oncogene. 19:1589-1595
We introduced a functional p16 cDNA into non-small cell lung cancer (NSCLC) cell lines expressing different combinations of normal and mutated p16, p53, and Rb genes via a recombinant adenovirus to determine the effect of exogenous p16 expression on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4698e9871d18a191b588e7d9e9442ae5
https://doi.org/10.1038/sj.onc.1203466
https://doi.org/10.1038/sj.onc.1203466
Autor:
Xiao-Yi Sun, Ian H. Frazer, A. B. Jenson, H. Zentgraf, Martin Müller, Jian Zhou, A. Alonso, R. J. Cristiano, Lutz Gissmann
Publikováno v:
Scopus-Elsevier
The inability of papillomaviruses (PV) to replicate in tissue culture cells has hampered the study of the PV life cycle. We investigated virus-cell interactions by the following two methods: (i) using purified bovine PV virions or human PV type 11 (H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0493f7845159f9c876375dc1c47df512
https://doi.org/10.1128/jvi.69.2.948-954.1995
https://doi.org/10.1128/jvi.69.2.948-954.1995
Autor:
A S, Pearson, F R, Spitz, S G, Swisher, M, Kataoka, M G, Sarkiss, R E, Meyn, T J, McDonnell, R J, Cristiano, J A, Roth
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(3)
Overexpression of wild-type p53 in cancer cells by adenovirus-mediated p53 gene transfer can result in the induction of apoptosis. To identify the potential mediators of this p53-induced apoptosis, we examined apoptotic protein levels in human lung c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::482dfc4b015cb3a8ac1310ea2aefedd2
https://pubmed.ncbi.nlm.nih.gov/10741712
https://pubmed.ncbi.nlm.nih.gov/10741712
Autor:
D M, Beaupre, M, Talpaz, F C, Marini, R J, Cristiano, J A, Roth, Z, Estrov, M, Albitar, M H, Freedman, R, Kurzrock
Publikováno v:
Cancer research. 59(12)
Interleukin (IL)-1beta is constitutively expressed in many leukemias and operates as an autocrine growth factor. To study the cellular basis for this aberrant production, we analyzed two cell lines, B1 (acute lymphoblastic leukemia) and W1 (juvenile
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cce40d04f922d4589c5489d35b9e789
https://pubmed.ncbi.nlm.nih.gov/10383163
https://pubmed.ncbi.nlm.nih.gov/10383163
Autor:
Pamela Gehron Robey, Beatrice Sommer, R. J. Cristiano, M. F. Young, Brian O'Connell, Sergei A. Kuznetsov
Publikováno v:
Calcified tissue international. 64(1)
In order to assess efficient DNA gene transfer into human primary cell cultures derived from the skeleton we tested two viral-based procedures. First, replication-deficient recombinant adenoviruses (ADV) were used to infect post-confluent human marro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4914a007a804f759c91c42a8429f6fc0
https://pubmed.ncbi.nlm.nih.gov/9868283
https://pubmed.ncbi.nlm.nih.gov/9868283
Autor:
R J, Cristiano
Publikováno v:
Anticancer research. 18(5A)
Our research has focused on developing improved delivery vectors for treating cancer by gene therapy using the tumor suppressor p53 gene.Recombinant viral and non-viral vectors were used to deliver the p53 gene into non-small cell lung cancer (NSCLC)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::157b92464cd94b85923822679b631279
https://pubmed.ncbi.nlm.nih.gov/9858889
https://pubmed.ncbi.nlm.nih.gov/9858889
Publikováno v:
Cancer research. 58(21)
Low levels of gene expression following systemic delivery have impaired the effectiveness of tumor suppressor gene replacement in treating metastases. We asked whether combined treatment with 2-methoxyestradiol (2-Me), which increases levels of wild-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d2815b0542025989281b684c1a6870e8
https://pubmed.ncbi.nlm.nih.gov/9809972
https://pubmed.ncbi.nlm.nih.gov/9809972
Publikováno v:
Cancer gene therapy. 4(3)
Current viral delivery systems suffer from disadvantages that may limit the rate at which therapeutic gene expressing constructs can be tested both in vitro and in vivo. In this study, our focus was to develop a simple gene delivery system for the ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a039d143ddc5cfed148298b94f3f5100
https://pubmed.ncbi.nlm.nih.gov/9171937
https://pubmed.ncbi.nlm.nih.gov/9171937
Publikováno v:
Cancer gene therapy. 4(3)
An adenovirus/DNA complex was constructed by chemically linking poly-L-lysine to the capsid of the replication-defective adenovirus dl312, allowing for coupling with plasmid DNA by an ionic interaction. We have previously demonstrated that this adeno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3f02dde1d6723cda4a36f9a928e991a0
https://pubmed.ncbi.nlm.nih.gov/9171938
https://pubmed.ncbi.nlm.nih.gov/9171938
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 2(10)
Wild-type p53 gene transfer into the SW620 colorectal carcinoma cell line was performed using the replication-defective adenovirus Ad5/CMV/p53 to evaluate the effect of wild-type p53 expression on radiation sensitivity. The results indicated that inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::410f821450f6e8e5c1550fa357785016
https://pubmed.ncbi.nlm.nih.gov/9816114
https://pubmed.ncbi.nlm.nih.gov/9816114