Výsledky vyhledávání

The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. Involvement of death receptor-related signaling pathways

Autor: L H, Xu, X, Yang, C A, Bradham, D A, Brenner, A S, Baldwin, R J, Craven, W G, Cance

Publikováno v: The Journal of biological chemistry. 275(39)

The focal adhesion kinase (FAK) is a mediator of cell-extracellular matrix signaling events and is overexpressed in tumor cells. In order to rapidly down-regulate FAK function in normal and transformed mammary cells, we have used adenoviral gene tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::75c35b9711a0c99f573a03e20719bf81
https://pubmed.ncbi.nlm.nih.gov/10899173

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The COOH-terminal domain of the focal adhesion kinase induces loss of adhesion and cell death in human tumor cells

Autor: L H, Xu, X, Yang, R J, Craven, W G, Cance

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 9(12)

Focal adhesion kinase (FAK) is a tyrosine kinase that is linked to signaling pathways between cells and their extracellular matrix. An alternate transcript of the COOH-terminal region of the FAK gene, called FAK-related nonkinase, has been shown to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a8d10c85de0da80ec001987c1fef497
https://pubmed.ncbi.nlm.nih.gov/9869300

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Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells

Autor: L H, Xu, L V, Owens, G C, Sturge, X, Yang, E T, Liu, R J, Craven, W G, Cance

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(4)

The focal adhesion kinase (FAK) is a nonreceptor protein tyrosine kinase implicated in integrin-mediated signal transduction pathways, oncogenic transformation by v-src, and the invasion of human tumors. The overexpression of p125FAK in a variety of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::02f519eb014fff690486ec751a557fe6
https://pubmed.ncbi.nlm.nih.gov/9052982

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The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb

Autor: R J, Craven, W G, Cance, E T, Liu

Publikováno v: Cancer research. 55(18)

Rak is a nuclear tyrosine kinase containing Src homology 2 and 3 domains at its NH2 terminus. We report here that the retinoblastoma tumor susceptibility gene product pRb associates with Rak in vivo and in vitro. Rak binds in the A/B pocket region of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b63c7fb2bd64a21152cf9d4aae83fb3e
https://pubmed.ncbi.nlm.nih.gov/7664264

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Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors

Autor: L V, Owens, L, Xu, R J, Craven, G A, Dent, T M, Weiner, L, Kornberg, E T, Liu, W G, Cance

Publikováno v: Cancer research. 55(13)

The focal adhesion kinase (FAK) gene encodes a tyrosine kinase (p125FAK) thought to be involved in signal transduction pathways used in cell adhesion, motility, and anchorage-independent growth. Because alterations in these cellular processes occur i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1652d0c69a84908772f9290eb468bdaa
https://pubmed.ncbi.nlm.nih.gov/7796399

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The Hallstde Steelworks Project

Autor: D. R. J. Craven

Publikováno v: Contaminated Soil ’95 ISBN: 9789401041881

The basic project is to plant a 32 ha contaminated steelworks site situated in a very visible position on the eastern edge of Glasgow with a mixture of native hardwoods and short rotation energy coppice — mostly willow species. The site has lain ab

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cac08d2626aa92eaed5c971a7cd90900
https://doi.org/10.1007/978-94-011-0421-0_168

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Rak, a novel nuclear tyrosine kinase expressed in epithelial cells

Autor: W G, Cance, R J, Craven, M, Bergman, L, Xu, K, Alitalo, E T, Liu

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 5(12)

We have identified a new tyrosine kinase from human breast cancer cells called Rak (a Russian word for cancer) that shares 51% identity with c-Src. Sequencing of the full-length complementary DNA revealed that Rak is a tyrosine kinase with a molecula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::48c96cc0e381f0e9554597838e6810a6
https://pubmed.ncbi.nlm.nih.gov/7696183

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Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern

Autor: E N, Levedakou, M, He, E W, Baptist, R J, Craven, W G, Cance, P L, Welcsh, A, Simmons, S L, Naylor, R J, Leach, T B, Lewis

Publikováno v: Oncogene. 9(7)

Using polymerase chain reaction (PCR)-based methods, we have isolated cDNA clones of two new members of serine/threonine kinases, STK1 and STK2, from a cDNA library constructed from the BT-20 human breast cancer cell line. STK1 is transcribed as a 1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7f71d6494ea00f2870f87c39720e182b
https://pubmed.ncbi.nlm.nih.gov/8208544

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