Zobrazeno 1 - 10
of 182
pro vyhledávání: '"R I, Shader"'
Publikováno v:
British journal of pharmacology. 134(8)
1. Chronic use of Saint John's wort (SJW) has been shown to lower the bioavailability for a variety of co-administered drugs including indinavir, cyclosporin, and digoxin. Decreases in intestinal absorption through induction of the multidrug resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::85e07b530d462a407a8ab0c9e8929c94
https://pubmed.ncbi.nlm.nih.gov/11739235
https://pubmed.ncbi.nlm.nih.gov/11739235
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(8)
Transformation of escitalopram (S-CT), the pharmacologically active S-enantiometer of citalopram, to S-desmethyl-CT (S-DCT), and of S-DCT to S-didesmethyl-CT (S-DDCT), was studied in human liver microsomes and in expressed cytochromes (CYPs). Biotran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d1c75c92677e0df1c1b7f27a22ba983
https://pubmed.ncbi.nlm.nih.gov/11454728
https://pubmed.ncbi.nlm.nih.gov/11454728
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(2)
The kinetics of flunitrazepam (FNTZ) N-demethylation to desmethylflunitrazepam (DM FNTZ), and 3-hydroxylation to 3-hydroxyflunitrazepam (3-OH FNTZ), were studied in human liver microsomes and in microsomes containing heterologously expressed individu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ee476a05f83dd97cb30c0a38b00d03da
https://pubmed.ncbi.nlm.nih.gov/11159802
https://pubmed.ncbi.nlm.nih.gov/11159802
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(2)
Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse transcriptase inhibitors and viral protease inhibitors was studied in vitro in human liver microsomes using bupropion hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3c2f31f28ae8120237879e1fda89be28
https://pubmed.ncbi.nlm.nih.gov/11159797
https://pubmed.ncbi.nlm.nih.gov/11159797
Autor:
L M, Hesse, K, Venkatakrishnan, M H, Court, L L, von Moltke, S X, Duan, R I, Shader, D J, Greenblatt
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
The in vitro biotransformation of bupropion to hydroxybupropion was studied in human liver microsomes and microsomes containing heterologously expressed human cytochromes P450 (CYP). The mean (+/-S.E.) K(m) in four human liver microsomes was 89 (+/-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd3faeb43bb359fb0393edd46ebe24a5
https://pubmed.ncbi.nlm.nih.gov/10997936
https://pubmed.ncbi.nlm.nih.gov/10997936
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(10)
The metabolism of the antidepressant mirtazapine (MIR) was investigated in vitro using human liver microsomes (HLM) and recombinant enzymes. Mean K(m) values (+/-S.D., n = 4) were 136 (+/-44) microM for MIR-hydroxylation, 242 (+/-34) microM for N-dem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb6042a6abfc52bb3a48d8faef6be94c
https://pubmed.ncbi.nlm.nih.gov/10997935
https://pubmed.ncbi.nlm.nih.gov/10997935
Publikováno v:
Biopharmaceuticsdrug disposition. 20(8)
Zafirlukast is a cysteinyl leukotriene antagonist used to treat allergic and exercise-induced asthma. This in vitro study used human liver microsomes to evaluate the inhibitory activity of zafirlukast versus six human cytochrome P450 (CYP) isoforms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d22dc04ec5ebdab9fa3e480c2ea2db6b
https://pubmed.ncbi.nlm.nih.gov/10870095
https://pubmed.ncbi.nlm.nih.gov/10870095
Autor:
D J, Greenblatt, J S, Harmatz, L L, von Moltke, C E, Wright, A L, Durol, L M, Harrel-Joseph, R I, Shader
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 293(2)
Eighteen healthy volunteers (10 men and 8 women) participated in a single-dose, double-blind, three-way crossover pharmacokinetic and pharmacodynamic study. Treatment conditions were 0.25 mg of triazolam, a full-agonist benzodiazepine ligand; 10 mg o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c24466e138202a62dc3127de5b08c520
https://pubmed.ncbi.nlm.nih.gov/10773013
https://pubmed.ncbi.nlm.nih.gov/10773013
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(4)
The in vitro biotransformation of sildenafil to its major circulating metabolite, UK-103,320, was studied in human liver microsomes and in microsomes containing heterologously expressed human cytochromes. In human liver microsomes, the mean K(m) (+/-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96e02578eedf912b45e58d16936391a5
https://pubmed.ncbi.nlm.nih.gov/10725306
https://pubmed.ncbi.nlm.nih.gov/10725306
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(3)
To study age-related changes in drug metabolism, we examined the in vitro biotransformation of midazolam (MDZ), a human cytochrome P-450 (CYP) 3A substrate, using liver microsomes from three age groups of male CD-1 mice ranging from 6 weeks to 2 year
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3b2ea74982770a7e54bb508031330df
https://pubmed.ncbi.nlm.nih.gov/10688619
https://pubmed.ncbi.nlm.nih.gov/10688619