Zobrazeno 1 - 10
of 116
pro vyhledávání: '"R Huck"'
Autor:
Casey M. Setash, Adam C. Behney, James H. Gammonley, Cory T. Overton, Michael L. Casazza, Frédéric Letourneux, Frances E. Buderman, Michael L. Schummer, Benjamin Z. Luukkonen, Nathaniel R. Huck, Karen E. Beatty, Pierre Legagneux, David N. Koons
Publikováno v:
Animal Biotelemetry, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract GPS tags have become a common tool in ecological studies of animal behaviour and demography despite previous research indicating negative impacts on vital rates across a variety of taxa. Many researchers face tradeoffs when deciding whether
Externí odkaz:
https://doaj.org/article/19c6c586a8ad42b299c9a1909441b64e
Publikováno v:
Atmospheric Chemistry and Physics, Vol 23, Pp 6299-6318 (2023)
The observation and quantification of mineral dust fluxes from high-latitude sources remains difficult due to a known paucity of year-round in situ observations and known limitations of satellite remote sensing data (e.g. cloud cover and dust detecti
Externí odkaz:
https://doaj.org/article/01e154954bb4469989197e824f0811f3
Autor:
L Cybulski, N Chilman, A Jewell, M E Dewey, R Hildersley, C Morgan, R Huck, M Hotopf, R Stewart, M Pritchard, M Wuerth, J Das-Munshi
ObjectivesTo address the lack of individual-level socioeconomic information in electronic health care records, we linked the 2011 census of England and Wales to patient records from a large mental healthcare provider. This paper describes the linkage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b17f2e8caf0c68e3febe91116928dfe9
https://doi.org/10.1101/2023.03.10.23287114
https://doi.org/10.1101/2023.03.10.23287114
Autor:
Brian H. Heasley, Jing Lin, Thomas F. N. Haxell, Igor Mochalkin, Constantin Neagu, Felix Rohdich, Ruoxi Lan, Amanda E. Sutton, Jennifer Jackson, Potnick Justin, Bayard R. Huck, Andreas Machl, Katrin Georgi, Xiaoling Chen, Sherer Brian A, Erik Wilker, Thomas E. Richardson, Anderson Clark, Reinaldo Jones, Johnson Theresa L, Lizbeth Celeste Deselm, Andreas Goutopoulos, Hui Tian, Yufang Xiao, Joseph A. Moore, Lindsey Crowley
Publikováno v:
Journal of Medicinal Chemistry. 64:14603-14619
Herein, we report the discovery of a novel class of quinazoline carboxamides as dual p70S6k/Akt inhibitors for the treatment of tumors driven by alterations to the PI3K/Akt/mTOR (PAM) pathway. Through the screening of in-house proprietary kinase libr
Publikováno v:
Nature Reviews Chemistry. 7:3-4
Publikováno v:
eLife, Vol 4 (2015)
Adaptations to an organism's environment often involve sensory system modifications. In this study, we address how evolutionary divergence in sensory perception relates to the physiological coding of stimuli. Mormyrid fishes that can detect subtle va
Externí odkaz:
https://doaj.org/article/89cdcc6e0d524c47bf0c82d5d2764510
Autor:
Ruoxi Lan, Hui Tian, Dusica Santos, Lizbeth Celeste Deselm, Jing Lin, Donald Bankston, Constantin Neagu, Sherer Brian A, Jennifer Jackson, Jared Head, Jianguo Ma, Xuliang Jiang, Sakeena Syed, Anderson Clark, Andreas Machl, Yufang Xiao, Erik Wilker, Anna Gardberg, Xiaoling Chen, Igor Mochalkin, Bayard R. Huck, Hui Qiu, Christopher Charles Victor Jones, Vikram Dutt, Johnson Theresa L, Andreas Goutopoulos
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
Activation of the PI3K/Akt/mTOR kinase pathway is associated with human cancers. A dual p70S6K/Akt inhibitor is sufficient to inhibit strong tumor growth and to block negative impact of the compensatory Akt feedback loop activation. A scaffold dockin
Autor:
Dusica Cvetinovic Santos, Klaus Urbahns, Simone C. Zimmerli, Andreas Goutopoulos, Justin R. Potnick, Andrew Bender, Michael Meyring, Adam Shutes, Christopher Charles Victor Jones, Jared Head, Ben C. Askew, Bayard R. Huck, Ansgar Wegener, Hui Qiu, Theresa L. Johnson, Nadia Brugger, Sherer Brian A, Ngan Nguyen, Mohanraj Dhanabal, Ralf Schmidt, Roland Grenningloh, Reinaldo Jones, Richard D. Caldwell, Ariele Viacava Follis, Brian Healey, Montserrat Camps, Igor Mochalkin, Federica Morandi, Lesley Liu-Bujalski, Vikram Dutt, Brian L. Hodous, Anna Gardberg, Thomas Eichhorn
Publikováno v:
Journal of Medicinal Chemistry. 62:7643-7655
Bruton's tyrosine kinase (BTK) inhibitors such as ibrutinib hold a prominent role in the treatment of B cell malignancies. However, further refinement is needed to this class of agents, particularly in terms of adverse events (potentially driven by k
Autor:
Maria C. Canino, Felix Proessl, Juliana R. Hougland, James M. Baker, Deanna R. Huck, Bradley C. Nindl, Shawn D. Flanagan
Publikováno v:
Medicine & Science in Sports & Exercise. 54:344-344
Autor:
Yufang Xiao, Bayard R. Huck, Ruoxi Lan, Lizbeth DeSelm, Xiaoling Chen, Hui Qiu, Constantin Neagu, Theresa Johnson, Igor Mochalkin, Anna Gardberg, Xuliang Jiang, Hui Tian, Vikram Dutt, Dusica Santos, Jared Head, Jennifer Jackson, Sakeena Syed, Jing Lin, Erik Wilker, Jianguo Ma, Anderson Clark, Andreas Machl, Donald Bankston, Christopher C.V. Jones, Andreas Goutopoulos, Brian Sherer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 67:128758