The PRIMA Test Facility: SPIDER and MITICA test-beds for ITER neutral beam injectors

Autor: V Toigo, R Piovan, S Dal Bello, E Gaio, A Luchetta, R Pasqualotto, P Zaccaria, M Bigi, G Chitarin, D Marcuzzi, N Pomaro, G Serianni, P Agostinetti, M Agostini, V Antoni, D Aprile, C Baltador, M Barbisan, M Battistella, M Boldrin, M Brombin, M Dalla Palma, A De Lorenzi, R Delogu, M De Muri, F Fellin, A Ferro, A Fiorentin, G Gambetta, F Gnesotto, L Grando, P Jain, A Maistrello, G Manduchi, N Marconato, M Moresco, E Ocello, M Pavei, S Peruzzo, N Pilan, A Pimazzoni, M Recchia, A Rizzolo, G Rostagni, E Sartori, M Siragusa, P Sonato, A Sottocornola, E Spada, S Spagnolo, M Spolaore, C Taliercio, M Valente, P Veltri, A Zamengo, B Zaniol, L Zanotto, M Zaupa, D Boilson, J Graceffa, L Svensson, B Schunke, H Decamps, M Urbani, M Kushwah, J Chareyre, M Singh, T Bonicelli, G Agarici, A Garbuglia, A Masiello, F Paolucci, M Simon, L Bailly-Maitre, E Bragulat, G Gomez, D Gutierrez, G Mico, J-F Moreno, V Pilard, M Kashiwagi, M Hanada, H Tobari, K Watanabe, T Maejima, A Kojima, N Umeda, H Yamanaka, A Chakraborty, U Baruah, C Rotti, H Patel, M V Nagaraju, N P Singh, A Patel, H Dhola, B Raval, U Fantz, B Heinemann, W Kraus, S Hanke, V Hauer, S Ochoa, P Blatchford, B Chuilon, Y Xue, H P L De Esch, R Hemsworth, G Croci, G Gorini, M Rebai, A Muraro, M Tardocchi, M Cavenago, M D’Arienzo, S Sandri, A Tonti

Publikováno v: New Journal of Physics, Vol 19, Iss 8, p 085004 (2017)

The ITER Neutral Beam Test Facility (NBTF), called PRIMA (Padova Research on ITER Megavolt Accelerator), is hosted in Padova, Italy and includes two experiments: MITICA, the full-scale prototype of the ITER heating neutral beam injector, and SPIDER,

Externí odkaz: https://doaj.org/article/cc638a311cb44ec88e0188269887ed6d

Discovery, activity and characterisation of an AA10 lytic polysaccharide oxygenase from the shipworm symbiont Teredinibacter turnerae

Autor: Claire. A. Fowler, Federico Sabbadin, Luisa Ciano, Glyn R. Hemsworth, Luisa Elias, Neil Bruce, Simon McQueen-Mason, Gideon J. Davies, Paul H. Walton

Publikováno v: Biotechnology for Biofuels, Vol 12, Iss 1, Pp 1-11 (2019)

Abstract Background The quest for novel enzymes for cellulosic biomass-degradation has recently been focussed on lytic polysaccharide monooxygenases (LPMOs/PMOs), Cu-containing proteins that catalyse the oxidative degradation of otherwise recalcitran

Externí odkaz: https://doaj.org/article/c163630a997e4bf88ba2a529feecb1d8

An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion

Autor: Federico Sabbadin, Glyn R. Hemsworth, Luisa Ciano, Bernard Henrissat, Paul Dupree, Theodora Tryfona, Rita D. S. Marques, Sean T. Sweeney, Katrin Besser, Luisa Elias, Giovanna Pesante, Yi Li, Adam A. Dowle, Rachel Bates, Leonardo D. Gomez, Rachael Simister, Gideon J. Davies, Paul H. Walton, Neil C. Bruce, Simon J. McQueen-Mason

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

LPMOs catalyze the oxidative breakdown of polysaccharides, thereby facilitating biomass degradation. By analyzing the digestive proteome of firebrats, the authors here identify a yet uncharacterized LPMO family and provide phylogenetic, structural an

Externí odkaz: https://doaj.org/article/5046c175d9224ed5b66ba1feaf872fe8

A Standalone β-Ketoreductase Acts Concomitantly with Biosynthesis of the Antimycin Scaffold

Autor: Michael E. Webb, Ryan F. Seipke, Glyn R. Hemsworth, Asif Fazal

Publikováno v: ACS Chemical Biology. 16:1152-1158

Antimycins are anticancer compounds produced by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) pathway. The biosynthesis of these compounds is well characterized, with the exception of the standalone β-ketoreductase enzyme A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154ae477dc70f5f08e4415daf331e500
https://doi.org/10.1021/acschembio.1c00229

Structural dissection of a complex Bacteroides ovatus gene locus conferring xyloglucan metabolism in the human gut

Autor: Glyn R. Hemsworth, Andrew J. Thompson, Judith Stepper, Łukasz F. Sobala, Travis Coyle, Johan Larsbrink, Oliver Spadiut, Ethan D. Goddard-Borger, Keith A. Stubbs, Harry Brumer, Gideon J. Davies

Publikováno v: Open Biology, Vol 6, Iss 7 (2016)

The human gastrointestinal tract harbours myriad bacterial species, collectively termed the microbiota, that strongly influence human health. Symbiotic members of our microbiota play a pivotal role in the digestion of complex carbohydrates that are o

Externí odkaz: https://doaj.org/article/6f176a45581e4a0a8c6376f9ee3dc073