Zobrazeno 1 - 10
of 2 562
pro vyhledávání: '"R Heath"'
As economic power diffuses across more countries and China becomes more dependent on the world economy, Chinese leaders are being forced to abandon their largely passive approach to global governance. This report analyzes China's interests and behavi
Autor:
Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 3
Externí odkaz:
https://doaj.org/article/795dea3b15b941688aa5f281361c1332
Publikováno v:
Biogeosciences, Vol 19, Pp 2417-2426 (2022)
The spring phytoplankton bloom is a key event in temperate and polar seas, yet the mechanisms that trigger it remain under debate. Some hypotheses claim that the spring bloom onset occurs when light is no longer limiting, allowing phytoplankton divis
Externí odkaz:
https://doaj.org/article/312a3bb5c235495ea10135b6408e7d2c
Autor:
Darryl N. Johnson, Zheng Ruan, Emma V. Petley, Sapna Devi, Lauren E. Holz, Adam P. Uldrich, Jeffrey Y. W. Mak, Jyh Liang Hor, Scott N. Mueller, James McCluskey, David P. Fairlie, Phillip K. Darcy, Paul A. Beavis, William R. Heath, Dale I. Godfrey
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-22 (2022)
Abstract Natural Killer T (NKT) cells and Mucosal-Associated Invariant T (MAIT) cells are innate-like T cells that express semi-invariant αβ T cell receptors (TCRs) through which they recognise CD1d and MR1 molecules, respectively, in complex with
Externí odkaz:
https://doaj.org/article/752fb81bb7254b64a74120356ca7f38e
Autor:
Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here the authors carry out chemical kinetic studies revealing that aggregation of hIAPP and its variant S20G involves secondary nucleation. Two small molecules with novel scaffolds are shown to inhibit or accelerate aggregation by binding different m
Externí odkaz:
https://doaj.org/article/d21098cc865040188a3674711bd2d77e
Autor:
M. C. Pace, D. M. Bailey, D. W. Donnan, B. E. Narayanaswamy, H. J. Smith, D. C. Speirs, W. R. Turrell, M. R. Heath
Publikováno v:
Earth System Science Data, Vol 13, Pp 5847-5866 (2021)
High-quality quantitative maps of seabed sedimentary physical and geochemical properties have numerous research and conservation applications, including habitat and ecosystem modelling, marine spatial planning, and ecosystem service mapping. However,
Externí odkaz:
https://doaj.org/article/e8dc9a9f595c47268523024d6f7f6e16
Autor:
Timothy R. Heath
For the first time since its founding in 1921, the Chinese Communist Party (CCP) has adopted a new paradigm for its role in China. Abandoning its former identity as a'revolutionary party', the CCP now regards itself as a'governing party'committed to
Autor:
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing
Externí odkaz:
https://doaj.org/article/d1a033da7da847f699478c811b28f10b
Autor:
Raghavendar Reddy Sanganna Gari, Joel José Montalvo‐Acosta, George R. Heath, Yining Jiang, Xiaolong Gao, Crina M. Nimigean, Christophe Chipot, Simon Scheuring
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
High-speed atomic force microscopy height spectroscopy and single channel electrophysiology recordings are used to correlate conformational and functional dynamics of the model membrane protein, outer membrane protein G (OmpG). These techniques show
Externí odkaz:
https://doaj.org/article/244843fefff4420181bab8bb8e548a7e
Autor:
Yue Lu, Alphonsus H. C. Ng, Frances E. Chow, Richard G. Everson, Beth A. Helmink, Michael T. Tetzlaff, Rohit Thakur, Jennifer A. Wargo, Timothy F. Cloughesy, Robert M. Prins, James R. Heath
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The response to neoadjuvant immune checkpoint blockade (ICB) in patients with recurrent gliolastoma multiforme (GBM) has been challenging to interpret. Here the authors develop a tumor analysis framework that reveals molecular similarities between GB
Externí odkaz:
https://doaj.org/article/da58c67153ba43c0bfe64ab0eaad9f67