Zobrazeno 1 - 10
of 2 107
pro vyhledávání: '"R Harrington"'
Autor:
Mohammad Arastoo, Lewis K. Penny, Richard Lofthouse, Aya Abdallah, Anna Abrahamsson, Pietro Marini, Valeria Melis, Gernot Riedel, Charles R. Harrington, Claude M. Wischik, Andrew Porter, Soumya Palliyil
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-20 (2024)
Abstract Background Recent advances in blood-based biomarker discovery are paving the way for simpler, more accessible diagnostic tools that can detect early signs of Alzheimer’s disease (AD). Recent successes in the development of amyloid-targetin
Externí odkaz:
https://doaj.org/article/3efb8c85249a4d3e81c8e65617f504f9
Autor:
Lewis K. Penny, Richard Lofthouse, Mohammad Arastoo, Andy Porter, Soumya Palliyil, Charles R. Harrington, Claude M. Wischik
Publikováno v:
Translational Neurodegeneration, Vol 13, Iss 1, Pp 1-14 (2024)
Abstract The use of biomarker-led clinical trial designs has been transformative for investigating amyloid-targeting therapies for Alzheimer’s disease (AD). The designs have ensured the correct selection of patients on these trials, supported targe
Externí odkaz:
https://doaj.org/article/73f382a2bce1401e95495cc3facd6bb0
Autor:
Karima Schwab, Mandy Magbagbeolu, Franz Theuring, Charles R. Harrington, Claude M. Wischik, Gernot Riedel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract The accumulation of α-synuclein (α-Syn) into Lewy bodies is a hallmark of synucleinopathies, a group of neurological disorders that include Parkinson’s disease (PD) and dementia with Lewy bodies (DLB). Small oligomers as well as larger f
Externí odkaz:
https://doaj.org/article/1ad118a61c2b453db472d785f41f7ed3
Autor:
Karima Schwab, Dilyara Lauer, Mandy Magbagbeolu, Franz Theuring, Anna Gasiorowska, Maciej Zadrozny, Charles R. Harrington, Claude M. Wischik, Grażyna Niewiadomska, Gernot Riedel
Publikováno v:
Brain Research Bulletin, Vol 212, Iss , Pp 110955- (2024)
In clinical trials for Alzheimer’s disease (AD), hydromethylthionine mesylate (HMTM) showed reduced efficacy when administered as an add-on to symptomatic treatments, while it produced a significant improvement of cognitive function when taken as m
Externí odkaz:
https://doaj.org/article/55dcde6ffee8464392a774ea753330c1
Autor:
I Goodyer, B Dubicka, P Wilkinson, R Kelvin, C Roberts, S Byford, S Breen, C Ford, B Barrett, A Leech, J Rothwell, L White, R Harrington
Publikováno v:
Health Technology Assessment, Vol 12, Iss 14 (2008)
Externí odkaz:
https://doaj.org/article/20e8e0fae0924253a4ab9e5d4d19d2d7
Autor:
Maciej Zadrozny, Patrycja Drapich, Anna Gasiorowska-Bien, Wiktor Niewiadomski, Charles R. Harrington, Claude M. Wischik, Gernot Riedel, Grazyna Niewiadomska
Publikováno v:
Cells, Vol 13, Iss 7, p 642 (2024)
Basal forebrain cholinergic dysfunction, most likely linked with tau protein aggregation, is a characteristic feature of Alzheimer’s disease (AD). Recent evidence suggests that tau protein is a putative target for the treatment of dementia, and the
Externí odkaz:
https://doaj.org/article/08f2654462fb4a6f97b2a4c2ca2ac9d8
Autor:
Meir Alkon, Yaoping Wang, Matthew R Harrington, Claudia Shi, Ryan Kennedy, Johannes Urpelainen, Jacob Kopas, Xiaogang He
Publikováno v:
Environmental Research Letters, Vol 19, Iss 4, p 044072 (2024)
Food production in much of the world relies on groundwater resources. In many regions, groundwater levels are declining due to a combination of anthropogenic extraction, localized meteorological and geological characteristics, and climate change. Gro
Externí odkaz:
https://doaj.org/article/67b3549f194f4ce4aa8f4772e9af6351
Autor:
Matthew Wortham, Fenfen Liu, Austin R. Harrington, Johanna Y. Fleischman, Martina Wallace, Francesca Mulas, Medhavi Mallick, Nicholas K. Vinckier, Benjamin R. Cross, Joshua Chiou, Nisha A. Patel, Yinghui Sui, Carolyn McGrail, Yesl Jun, Gaowei Wang, Ulupi S. Jhala, Roland Schüle, Orian S. Shirihai, Mark O. Huising, Kyle J. Gaulton, Christian M. Metallo, Maike Sander
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 8 (2023)
Adaptation of the islet β cell insulin-secretory response to changing insulin demand is critical for blood glucose homeostasis, yet the mechanisms underlying this adaptation are unknown. Here, we have shown that nutrient-stimulated histone acetylati
Externí odkaz:
https://doaj.org/article/b59ff5cf14e54435855ccfd8a98f4b14
Autor:
Maria C. R. Harrington
Publikováno v:
Frontiers in Virtual Reality, Vol 4 (2023)
This is a perspective that presents a viewpoint on immersive informal learning applications built as digital twins of the natural world. Such applications provide multimodal, interactive, immersive, embodied, and sensory experiences unique and differ
Externí odkaz:
https://doaj.org/article/8d189b0de9ea48d8b7fb6c1e911372c3
Autor:
Mohammad Arastoo, Michael P. Mazanetz, Sonya Miller, Helen Shiells, Claire Hull, Keith Robinson, John M. D. Storey, Charles R. Harrington, Claude M. Wischik
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 18, p 13747 (2023)
Methylthioninium chloride (MTC) is a standard treatment for methaemoglobinaemia. A preparation of reduced MTC has been reported to increase blood oxygen saturation (SpO2) and lower respiratory rates in patients with severe COVID-19. We have developed
Externí odkaz:
https://doaj.org/article/df9df7c6b5b1455c99ae12ce7f3e9e71