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A Two-Site Chemiluminescent Assay for Activin-Free Follistatin Reveals That Most Follistatin Circulating in Men and Normal Cycling Women Is in an Activin-Bound State1

Autor: Nancy E. Reame, Qifa Wang, R H Khoury, Daniel S. McConnell, William F. Crowley, Patrick M. Sluss, A. Rees Midgley, Alan L. Schneyer, Nicola Bolf, Vasantha Padmanabhan

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 83:851-858

Follistatin (FS) is a monomeric protein that binds and regulates the bioavailability of activin. Previously, we found circulating levels of total FS to be similar in men and cycling women. Because relative amounts of activin-bound and free FS are imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5b8b01771932ddf47803e023a612821f
https://doi.org/10.1210/jcem.83.3.4651

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A two-site chemiluminescent assay for activin-free follistatin reveals that most follistatin circulating in men and normal cycling women is in an activin-bound state

Autor: D S, McConnell, Q, Wang, P M, Sluss, N, Bolf, R H, Khoury, A L, Schneyer, A R, Midgley, N E, Reame, W F, Crowley, V, Padmanabhan

Publikováno v: The Journal of clinical endocrinology and metabolism. 83(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a5a33c10b2471dacad2b1de7710ba2be
https://pubmed.ncbi.nlm.nih.gov/9506739

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Follistatin Physiology and Potential Mechanisms of Action in the Human

Autor: Patrick M. Sluss, Jeffrey Weiss, Qi Fa Wang, Ann E. Taylor, Janet E. Hall, William F. Crowley, Paul A. Boepple, Alan L. Schneyer, François P. Pralong, R H Khoury

Publikováno v: Inhibin, Activin and Follistatin ISBN: 9781461273202

Follistatin (FS) was originally identified and purified from porcine and bovine follicular fluid (pFF or bFF) side fractions remaining after purification and characterization of inhibin and activin (1–3). Like inhibin, FS was defined on the basis o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::448ae1e3c69ead8b856ead62042fee29
https://doi.org/10.1007/978-1-4612-1874-6_3

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Inhibin B secretion in males with gonadotropin-releasing hormone (GnRH) deficiency before and during long-term GnRH replacement: relationship to spontaneous puberty, testicular volume, and prior treatment--a clinical research center study

Autor: Lisa B. Nachtigall, Paul A. Boepple, Patrick M. Sluss, A E Lecain, William F. Crowley, R H Khoury, Stephanie B. Seminara

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(10)

To evaluate the physiology of inhibin B in the human male, we measured serum concentrations in normal adult men and men with isolated GnRH deficiency before and during long-term replacement with pulsatile GnRH. At baseline, inhibin B levels in the Gn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd13ffac0389c44b3be6a998279f98b1
https://pubmed.ncbi.nlm.nih.gov/8855795

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Inhibin B in males with gonadotropin-releasing hormone (GnRH) deficiency: changes in serum concentration after shortterm physiologic GnRH replacement--a clinical research center study

Autor: Stephanie B. Seminara, Patrick M. Sluss, François P. Pralong, R H Khoury, A E Lecain, Paul A. Boepple, William F. Crowley, Lisa B. Nachtigall

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(10)

To examine the role of inhibin B in the feedback regulation of FSH secretion in the human male, we determined serial levels in 18 men with idiopathic hypogonadotropic hypogonadism (IHH) during their initial 8 weeks of GnRH replacement. Pulsatile GnRH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac65239ecb4a261916f9a57e5e58326
https://pubmed.ncbi.nlm.nih.gov/8855824

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Homologous in vitro bioassay for follicle-stimulating hormone (FSH) reveals increased FSH biological signal during the mid- to late luteal phase of the human menstrual cycle

Autor: S Christin-Maitre, Patrick M. Sluss, P C Smith, R H Khoury, J L Jameson, Janet E. Hall, William F. Crowley, Kathryn A. Martin, C Albanese, Ann E. Taylor

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(6)

Monitoring of the secretory dynamics of FSH during the human menstrual cycle has demonstrated conflicting results between the amounts of FSH measured by dimer-specific immunoassays and previous heterologous in vitro bioassays. These differences sugge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2fdfc891c311e280c51e957f40f9e47
https://pubmed.ncbi.nlm.nih.gov/8964832

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A two-site monoclonal antibody immunoradiometric assay for human follistatin: secretion by a human ovarian teratocarcinoma-derived cell line (PA-1)

Autor: A. R. Midgley, Patrick M. Sluss, D S McConnell, Qifa Wang, Alan L. Schneyer, V Padmanahban, R H Khoury, P C Smith, William F. Crowley

Publikováno v: The Journal of clinical endocrinology and metabolism. 81(4)

The follistatin/activin/inhibin system increasingly appears to have important growth and differentiating effects in a variety of cell types, including cancer. We have developed a two-site immunoradiometric assay for measurement of human follistatin u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54b0faad30e12df3667e72fb39acfd7a
https://pubmed.ncbi.nlm.nih.gov/8636347

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Serum follistatin levels in women: evidence against an endocrine function of ovarian follistatin

Autor: A R Midgley, William F. Crowley, Patrick M. Sluss, Alan L. Schneyer, Thomas L. Toth, Janet E. Hall, Qifa Wang, R H Khoury

Publikováno v: The Journal of clinical endocrinology and metabolism. 80(4)

Follistatin is a monomeric protein first identified in and isolated from ovarian follicular fluid. Evidence that follistatin might be an ovarian endocrine hormone functioning in a negative feedback fashion to modulate pituitary FSH production is base

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da3ff383b9873ee970ec26fdcd0379b
https://pubmed.ncbi.nlm.nih.gov/7714112

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A comparison of 13 different immunometric assay kits for gonadotropins: implications for clinical investigation

Autor: Ann E. Taylor, William F. Crowley, R H Khoury

Publikováno v: The Journal of clinical endocrinology and metabolism. 79(1)

To determine whether the new immunometric (sandwich) assays for gonadotropins achieve the alleged improvements over RIAs, we compared 13 commercial kits for LH and FSH with our established and validated polyclonal RIAs. Although the kits claimed dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfb69308976d942c3d356a14c87a356d
https://pubmed.ncbi.nlm.nih.gov/8027235

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FOLLISTATIN (FS) AND INHIBIN A & B IN CENTRAL PRECOCIOUS PUBERTY(CPP): IMPACT OF GnRH AGONIST (GnRHa)-INDUCED PITUITARY DESENSITIZATION.• 491

Autor: R H Khoury, Paul A. Boepple, Patrick M. Sluss, William F. Crowley

Publikováno v: Pediatric Research. 39:84-84

FOLLISTATIN (FS) AND INHIBIN A & B IN CENTRAL PRECOCIOUS PUBERTY(CPP): IMPACT OF GnRH AGONIST (GnRHa)-INDUCED PITUITARY DESENSITIZATION.• 491

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6b2d6dba0fb7764a3e0741ba6fa65608
https://doi.org/10.1203/00006450-199604001-00511

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