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pro vyhledávání: '"R H, Wenger"'
Autor:
R. H. Wenger
Publikováno v:
ains · Anästhesiologie · Intensivmedizin · Notfallmedizin · Schmerztherapie. 39:38-43
Every cell of the body is capable of measuring the environmental oxygen concentration. When oxygen supply falls below oxygen demand of the cell (hypoxia), a series of genes will be activated whose products help the cell, the tissue as well as the who
Autor:
R H, Wenger
Publikováno v:
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS. 39
Every cell of the body is capable of measuring the environmental oxygen concentration. When oxygen supply falls below oxygen demand of the cell (hypoxia), a series of genes will be activated whose products help the cell, the tissue as well as the who
Autor:
R H, Wenger, C, Bauer
Publikováno v:
News in physiological sciences : an international journal of physiology produced jointly by the International Union of Physiological Sciences and the American Physiological Society. 16
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(7)
Publikováno v:
Experimental physiology. 85(6)
Genetically modified mice have become an invaluable tool in modern biomedical and basic research. This review provides an overview of knockout and transgenic mice studied with regard to their cutaneous wound healing properties. In addition, several g
Autor:
R M, Wanner, P, Spielmann, D M, Stroka, G, Camenisch, I, Camenisch, A, Scheid, D R, Houck, C, Bauer, M, Gassmann, R H, Wenger
Publikováno v:
Blood. 96(4)
Induction of erythropoietin (Epo) expression under hypoxic conditions is mediated by the heterodimeric hypoxia-inducible factor (HIF)-1. Following binding to the 3' hypoxia-response element (HRE) of the Epo gene, HIF-1 markedly enhances Epo transcrip
Publikováno v:
Advances in experimental medicine and biology. 475
Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis. HIF-1 consists of two subunits, HIF-1 alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT). Whereas hypoxia prevents ubiquitination and proteasom
Publikováno v:
Cancer research. 58(24)
Oxygen-deprived regions of a solid tumor can induce tumor suppressor p53 expression and hence select for p53-mutant tumor cells with diminished apoptotic potential. It has been proposed that the hypoxia-inducible factor-1 (HIF-1) alpha subunit binds
Publikováno v:
Blood. 91(9)
Hypoxic induction of erythropoietin (Epo) and other oxygen-dependent genes is mediated by the hypoxia-inducible factor-1 (HIF-1), a heterodimeric transactivator consisting of an alpha and a beta subunit. We previously found that the mouse gene encodi
Autor:
R H, Wenger, M, Gassmann
Publikováno v:
Biological chemistry. 378(7)
The hypoxia-inducible factor-1 (HIF-1) is a basic-helix-loop-helix (bHLH) heterodimeric transcription factor activated by reductions in oxygen concentration (hypoxia). Activated HIF-1 upregulates expression of genes involved in the adaptation of high