Zobrazeno 1 - 10
of 332
pro vyhledávání: '"R H, WHITE"'
Publikováno v:
Cell Death and Disease, Vol 15, Iss 3, Pp 1-12 (2024)
Abstract Cellular responses to TNF are inherently heterogeneous within an isogenic cell population and across different cell types. TNF promotes cell survival by activating pro-inflammatory NF-κB and MAPK signalling pathways but may also trigger apo
Externí odkaz:
https://doaj.org/article/781dabfa9abf45a18d7b78ff53e0cc63
Autor:
Polly Downton, James S. Bagnall, Hazel England, David G. Spiller, Neil E. Humphreys, Dean A. Jackson, Pawel Paszek, Michael R. H. White, Antony D. Adamson
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Cells respond to inflammatory stimuli such as cytokines by activation of the nuclear factor-κB (NF-κB) signalling pathway, resulting in oscillatory translocation of the transcription factor p65 between nucleus and cytoplasm in some cell types. We i
Externí odkaz:
https://doaj.org/article/0ae9f541650a4de1829a089cf962e69c
Publikováno v:
Weather and Climate Dynamics, Vol 2, Pp 777-794 (2021)
The efficacy of Euro-Atlantic circulation regimes for estimating wintertime climate anomalies (precipitation and surface temperature) over Europe is assessed. A comparison of seasonal climate reconstructions from two different regime frameworks (clus
Externí odkaz:
https://doaj.org/article/d714b4a70b0342969f0164bd3b995074
Autor:
Giorgos Minas, Dan J Woodcock, Louise Ashall, Claire V Harper, Michael R H White, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008076 (2020)
We consider how a signalling system can act as an information hub by multiplexing information arising from multiple signals. We formally define multiplexing, mathematically characterise which systems can multiplex and how well they can do it. While t
Externí odkaz:
https://doaj.org/article/04ee45a4dd7645fe931ba4f39c34efa6
Autor:
Hiroshi Momiji, Kirsty L Hassall, Karen Featherstone, Anne V McNamara, Amanda L Patist, David G Spiller, Helen C Christian, Michael R H White, Julian R E Davis, Bärbel F Finkenstädt, David A Rand
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007030 (2019)
Prolactin is a major hormone product of the pituitary gland, the central endocrine regulator. Despite its physiological importance, the cell-level mechanisms of prolactin production are not well understood. Having significantly improved the resolutio
Externí odkaz:
https://doaj.org/article/2bbb8bc2d77d4092b761e5d67d0c979f
Autor:
Louise E. King, Ricardo Rodriguez-Enriquez, Robert Pedley, Charlotte E. L. Mellor, Pengbo Wang, Egor Zindy, Michael R. H. White, Keith Brennan, Andrew P. Gilmore
Publikováno v:
Cell Death & Differentiation. 29:2262-2274
Apoptosis is regulated by interactions between the BH3-only and multi-domain Bcl-2 family proteins. These interactions are integrated on the outer mitochondrial membrane (OMM) where they set the threshold for apoptosis, known as mitochondrial priming
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21e57fd062a503420047e54a7f479f
https://doi.org/10.1038/s41418-022-01013-z
https://doi.org/10.1038/s41418-022-01013-z
Autor:
Antony Adamson, Christopher Boddington, Polly Downton, William Rowe, James Bagnall, Connie Lam, Apolinar Maya-Mendoza, Lorraine Schmidt, Claire V. Harper, David G. Spiller, David A. Rand, Dean A. Jackson, Michael R. H. White, Pawel Paszek
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
In biological systems, timing is often critical to the interpretation of signals that determine cell fate. Here the authors demonstrate how single cells and cellular populations respond dynamically to pulsatile stimulation by TNFα and IL-1β, and su
Externí odkaz:
https://doaj.org/article/1d4f418033bb45d7b771ae8b6ba8118e
Autor:
M. A. Stiller-Reeve, C. Heuzé, W. T. Ball, R. H. White, G. Messori, K. van der Wiel, I. Medhaug, A. H. Eckes, A. O'Callaghan, M. J. Newland, S. R. Williams, M. Kasoar, H. E. Wittmeier, V. Kumer
Publikováno v:
Hydrology and Earth System Sciences, Vol 20, Iss 7, Pp 2965-2973 (2016)
Science, in our case the climate and geosciences, is increasingly interdisciplinary. Scientists must therefore communicate across disciplinary boundaries. For this communication to be successful, scientists must write clearly and concisely, yet the h
Externí odkaz:
https://doaj.org/article/96ca548437dc4687954f08ad3b62a6a0
Autor:
Małgorzata Kardyńska, Anna Paszek, Jarosław Śmieja, David Spiller, Wiesława Widłak, Michael R H White, Pawel Paszek, Marek Kimmel
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 4, p e1006130 (2018)
Elevated temperature induces the heat shock (HS) response, which modulates cell proliferation, apoptosis, the immune and inflammatory responses. However, specific mechanisms linking the HS response pathways to major cellular signaling systems are not
Externí odkaz:
https://doaj.org/article/49065bcb4cdc48bb8108b4a3a8b1b574
Autor:
Francesco Lanucara, Connie Lam, Jelena Mann, Tom P. Monie, Stefano A. P. Colombo, Stephen W. Holman, James Boyd, Manohar C. Dange, Derek A. Mann, Michael R. H. White, Claire E. Eyers
Publikováno v:
Open Biology, Vol 6, Iss 7 (2016)
The NF-κB signalling module controls transcription through a network of protein kinases such as the IKKs, as well as inhibitory proteins (IκBs) and transcription factors including RelA/p65. Phosphorylation of the NF-κB subunits is critical for dic
Externí odkaz:
https://doaj.org/article/a34c79319d2c491f982226bd453d9392