Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R H, Shafer"'
Autor:
R H, Shafer, I, Smirnov
Publikováno v:
Biopolymers. 56(3)
Among the many unusual conformations of DNA and RNA, quadruplex structures, based on the guanine quartet, possess several unique properties. These properties, along with the general features of guanine quadruplexes, are described in the context of po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8f5aca3dd4785487422c1b591dc285a
https://pubmed.ncbi.nlm.nih.gov/11745112
https://pubmed.ncbi.nlm.nih.gov/11745112
Publikováno v:
Biopolymers. 54(2)
Mithramycin and chromomycin, two antitumor drugs, each having an identical aglycone and nearly identical disaccharide and trisaccharide side chains, have differing binding properties to a small oligonucleotide, d(ACCCGGGT)(2) (M. A. Keniry et al., Jo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbd8d98450a1403d6c111d9ee2d113e5
https://pubmed.ncbi.nlm.nih.gov/10861371
https://pubmed.ncbi.nlm.nih.gov/10861371
Autor:
I, Smirnov, R H, Shafer
Publikováno v:
Journal of molecular biology. 296(1)
DNA quadruplex structures based on the guanine quartet are typically stabilized by monovalent cations such as K(+), Na(+), or NH(+)(3). Certain divalent cations can also induce quadruplex formation, such as Sr(2+). Here we show that Pb(2+) binds with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7826d30c0c048eaf838ac87ee0f12c5f
https://pubmed.ncbi.nlm.nih.gov/10656813
https://pubmed.ncbi.nlm.nih.gov/10656813
Autor:
R H, Shafer
Publikováno v:
Progress in nucleic acid research and molecular biology. 59
This review focuses on the structural and thermodynamic characterization of model DNA triplex and quadruplex structures, taking into account effects of stoichiometry and sequence. Methods such as gel electrophoresis, UV melting, and scanning calorime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d7ace4053a654749da34891215784c5
https://pubmed.ncbi.nlm.nih.gov/9427840
https://pubmed.ncbi.nlm.nih.gov/9427840
Publikováno v:
Biopolymers. 41(4)
We have targeted the d[G(AG)5]. d[C(TC)5] duplex for triplex formation at neutral pH with either d[G(AG)5] or d[G(TG)5]. Using a combination of gel electrophoresis, uv and CD spectra, mixing and melting curves, along with DNase I digestion studies, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::192553694f1bf7f0ab6498a47bade813
https://pubmed.ncbi.nlm.nih.gov/9080778
https://pubmed.ncbi.nlm.nih.gov/9080778
Autor:
M A, Keniry, R H, Shafer
Publikováno v:
Methods in enzymology. 261
The application of high-resolution, multidimensional NMR techniques to the problem of determining the structure of drug-DNA complexes in solution has led to substantial progress in understanding the effect of drugs on DNA at the molecular level. With
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::036d8eaf80a9801a193b486e57627de4
https://pubmed.ncbi.nlm.nih.gov/8569513
https://pubmed.ncbi.nlm.nih.gov/8569513
Publikováno v:
European journal of biochemistry. 204(1)
Two-dimensional (2D) 1H-NMR spectroscopy has been used to analyze the structure of d(GCTTAAGC)2 and its interaction with berenil in solution. Nuclear Overhauser enhancement connectivities enabled sequential assignments of nearly all proton resonances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba239de360e5da9e939c9a87469c416f
https://pubmed.ncbi.nlm.nih.gov/1740143
https://pubmed.ncbi.nlm.nih.gov/1740143
Publikováno v:
Journal of molecular biology. 219(4)
The binding of spermine to the d(m5CGm5CGm5CG) duplex has been studied by proton and phosphorus nuclear magnetic resonance techniques in order to investigate the mobility and nature of spermine bound to the resulting Z-DNA complex. A characterization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::efb4d26645c64d5a7c2bdfca19d15547
https://pubmed.ncbi.nlm.nih.gov/1647463
https://pubmed.ncbi.nlm.nih.gov/1647463
Autor:
P V, Scaria, R H, Shafer
Publikováno v:
The Journal of biological chemistry. 266(9)
The interaction of ethidium, a DNA intercalator, with the poly(dA).poly(dT) duplex and the poly (dA).2poly(dT) triplex has been investigated by a variety of spectrophotometric and hydrodynamic techniques. The fluorescence of ethidium is increased whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d1d48f1c5dbfc6eacff988a0a24d832f
https://pubmed.ncbi.nlm.nih.gov/2005088
https://pubmed.ncbi.nlm.nih.gov/2005088
Publikováno v:
Radiation research. 109(1)
We used the filter elution technique to study DNA single- and double-strand scission under denaturing alkaline and nondenaturing conditions in X-irradiated 9L rat brain tumor cells. The amount of DNA damage determined by the alkaline elution assay wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca3ba772353f322fd03e7fd4849e74aa
https://pubmed.ncbi.nlm.nih.gov/3101131
https://pubmed.ncbi.nlm.nih.gov/3101131