Zobrazeno 1 - 10
of 210
pro vyhledávání: '"R H, Schwartz"'
Autor:
S Kitagawa-Sakakida, R H Schwartz
Publikováno v:
The Journal of Immunology. 157:2328-2339
The molecular mechanism underlying IL-2 transcriptional blockade in anergic T cell clones is not fully understood. To examine whether an active negative regulatory process occurs, we created a reporter construct containing as an enhancer four copies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c533888697e40ed0b86441d27e3826a1
https://doi.org/10.4049/jimmunol.157.6.2328
https://doi.org/10.4049/jimmunol.157.6.2328
Publikováno v:
The Journal of Immunology. 153:3014-3027
In this paper we demonstrate that IL-3 can act as a cofactor for the growth of some CD4+ T cells. This lymphokine synergized with IL-4 to induce both a unique set of protein tyrosine phosphorylations and the vigorous proliferation of the keyhole limp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b136335947dcf5d7c4527c2c05c064a
https://doi.org/10.4049/jimmunol.153.7.3014
https://doi.org/10.4049/jimmunol.153.7.3014
Autor:
L Chiodetti, R H Schwartz
Publikováno v:
The Journal of Immunology. 149:901-910
Rested murine CD4+ Th1 clones do not produce IL-4, but have previously been shown to be capable of responding to IL-4 if they are first activated with Ag and APC. In this study, we have examined the activation requirements for induction of competence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::014b5e08bbaf316e264a4ddb6ffa92da
https://doi.org/10.4049/jimmunol.149.3.901
https://doi.org/10.4049/jimmunol.149.3.901
Publikováno v:
The Journal of Immunology. 147:4118-4125
In this report we extend the in vitro clonal anergy model to examine the regulation of proliferation in T cells that secrete both IL-2 and IL-4. Newly cloned Ag-specific murine T cells are shown to depend on both IL-2 and IL-4 synthesis for maximal p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0585cf62018e70b83342ce9160f76824
https://doi.org/10.4049/jimmunol.147.12.4118
https://doi.org/10.4049/jimmunol.147.12.4118
Publikováno v:
The Journal of Immunology. 147:3601-3609
Cytokines are immunoregulatory proteins that are secreted by T lymphocytes and other cells upon activation. A controversy exists as to whether the induction of cytokine production is mediated at the transcriptional level by the initiation of RNA synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4514ff568c4672630fbf008d24f389ff
https://doi.org/10.4049/jimmunol.147.10.3601
https://doi.org/10.4049/jimmunol.147.10.3601
Publikováno v:
European journal of immunology. 31(12)
We have proposed a model in which the prevention of anergy by costimulation is the result of IL-2-induced G1 to S phase cell cycle progression. Here we demonstrate that the reversal of anergy by exogenous IL-2 also occurs during this window of the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbad99ba2dc17c9849d74f8767f6b95a
https://pubmed.ncbi.nlm.nih.gov/11745394
https://pubmed.ncbi.nlm.nih.gov/11745394
Publikováno v:
The Pediatric infectious disease journal. 20(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a166a8bfca4cb43a924949361a3d3f9b
https://pubmed.ncbi.nlm.nih.gov/11332684
https://pubmed.ncbi.nlm.nih.gov/11332684
Publikováno v:
Pediatrics in review. 21(12)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd636f213419d852e50e4ba411f30aa9
https://pubmed.ncbi.nlm.nih.gov/11121499
https://pubmed.ncbi.nlm.nih.gov/11121499
Publikováno v:
Ocular immunology and inflammation. 8(3)
To determine the efficacy and safety of nedocromil sodium 2% ophthalmic solution in the treatment of seasonal allergic conjunctivitis.A combined analysis of two multicenter, randomized, comparative, double-masked, placebo-controlled clinical trials i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76d24c0dcfd1cd41a13c7980b02e4ae1
https://pubmed.ncbi.nlm.nih.gov/11120577
https://pubmed.ncbi.nlm.nih.gov/11120577
Publikováno v:
European journal of immunology. 30(8)
Recent experiments have suggested that the IL-2 locus is monoallelically expressed. We tested this hypothesis using TCR-transgenic mice carrying one inactivated IL-2 allele. The frequency in single-cell assays of IL-2-producing cells following optima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebeeddfd9a67d61387d2b6361c835953
https://pubmed.ncbi.nlm.nih.gov/10940906
https://pubmed.ncbi.nlm.nih.gov/10940906