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Autor:
H L, McLeod, J, Cassidy, R H, Powrie, D G, Priest, M A, Zorbas, T W, Synold, S, Shibata, D, Spicer, D, Bissett, Y K, Pithavala, M A, Collier, L J, Paradiso, J D, Roberts
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)
Glycinamide ribonucleotide formyltransferase (GARFT) is a component of the de novo purine synthesis pathway. AG2034 is a specific inhibitor of GARFT that was designed based on the GARFT crystal structure. In conjunction with Phase I studies at four c