Zobrazeno 1 - 10
of 47
pro vyhledávání: '"R H, Lenox"'
Publikováno v:
Molecular Psychiatry. 8:135-144
The clinical efficacy of lithium in the prophylaxis of recurrent affective episodes in bipolar disorder is characterized by a lag in onset and remains for weeks to months after discontinuation. Thus, the long-term therapeutic effect of lithium likely
Publikováno v:
American Journal of Psychiatry. 151:1760-1766
OBJECTIVE This study was designed to examine the possibility that patients with panic disorder are especially vulnerable to alprazolam withdrawal, as well as to evaluate the efficacy of carbamazepine as adjunctive treatment during alprazolam disconti
Autor:
R H Lenox, D G Watson
Publikováno v:
Clinical Chemistry. 40:309-314
Lithium, an effective treatment for mania and the prevention of recurrent episodes of both mania and depression in patients with manic depressive illness, exerts multiple biochemical effects. However, any clinically relevant site of action of lithium
Publikováno v:
Journal of Neural Transmission. 87:77-83
Noradrenergic function was evaluated in the rat vas deferens following chronic treatment with lithium (30 mM in the diet for 2 weeks followed by 50 mM for 1 week). No alteration could be detected in: a) 3H-noradrenaline release evoked by electrical f
Publikováno v:
Handbook of Contemporary Neuropharmacology
Given the complexity of the interaction of the physiological, genetic and environmental factors driving the clinical expression of bipolar disorder phenotypes, its neurobiology is yet to be unraveled and avenues to new pharmacotherapies are just begi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aacebad17723464cc6a1e36903da5225
https://doi.org/10.1002/9780470101001.hcn022
https://doi.org/10.1002/9780470101001.hcn022
Publikováno v:
Journal of neurochemistry. 79(4)
The gene (Macs) for the mouse myristoylated alanine-rich C kinase substrate (MARCKS) encodes a prominent substrate for protein kinase C that has been implicated in processes requiring signal dependent changes in actin-membrane plasticity and cytoskel
Publikováno v:
The Journal of biological chemistry. 276(25)
We recently identified conformational changes that occur upon phosphorylation of myristoylated alanine-rich protein kinase C substrate (MARCKS) that preclude efficient cross-linking of actin filaments (Bubb, M. R., Lenox, R. H., and Edison, A. S. (19
Autor:
H K, Manji, R H, Lenox
Publikováno v:
The Journal of clinical psychiatry.
The underlying pathophysiology of bipolar disorder is a continually evolving complexity of multilayer interacting and independent systems. The dearth of adequate preclinical or clinical models that incorporate the various features of the illness, i.e
Autor:
R K, McNamara, R H, Lenox
Publikováno v:
Journal of neuroscience research. 62(3)
In the mature hippocampus, kainic acid seizures lead to excitotoxic cell death and synaptic reorganization in which granule cell axons (mossy fibers) form ectopic synapses on granule cell dendrites. In the present study, we examined the expression of
Autor:
R H, Lenox, C G, Hahn
Publikováno v:
The Journal of clinical psychiatry. 61
Since its discovery, lithium has been shown to act upon various neurotransmitter systems at multiple levels of signaling in the brain. Lithium, affecting each neurotransmitter system within complex interactive neuronal networks, is suggested to resto