Zobrazeno 1 - 10
of 19
pro vyhledávání: '"R H, Keith"'
Autor:
P. Adrian Evans, P. Rhodri Williams, Lisa J. Wakeman, Andrew Beddel, N. Thirumalai, Karl Hawkins, Roger C. Munro, M. S. Barrow, R. H. Keith Morris, Matthew Lawrence, D. J. Curtis, M. Rowan Brown
Publikováno v:
Rheologica Acta. 49:901-908
This study reports an automated numerical method for the location of the gel point in oscillatory shear data and demonstrates its potential application in measurements on therapeutically modified (heparinised) samples of healthy coagulating blood. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78d8100a664f550bbc2c3014fc5328d
https://doi.org/10.1007/s00397-010-0472-7
https://doi.org/10.1007/s00397-010-0472-7
Autor:
D. Spangler, James F Kachur, C. P. Anglin, Snyder Jp, Stella Siu-Tzyy Yu, T. D. Penning, S. W. Djuric, R H Keith, D. J. Fretland, Julie M Miyashiro
Publikováno v:
Journal of Medicinal Chemistry. 38:858-868
Our previous reports have highlighted the first-generation leukotriene B 4 (LTB 4 ) receptor antagonist SC-41930 (7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4-dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid) which has potent oral, topical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773bc091d74866da34ab5e26f8eef4b5
https://doi.org/10.1021/jm00006a002
https://doi.org/10.1021/jm00006a002
Autor:
D. J. Fretland, D. L. Widomski, Timothy S. Gaginella, James F. Kachur, T.J. Maziasz, C. P. Anglin, B.S. Tsai, Stella S. Yu, Tadimeti S. Rao, R. E. Walsh, R H Keith, Stephen H Docter, Stevan W. Djuric, D Villani-Price
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:811-816
The Structure Activity Relationship (SAR) studies leading to the identification of a novel high potency Leukotriene B4 receptor antagonist SC-53228 are delineated. This compound shows excelled pharmacodynamic efficacy in animal models of inflammatory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ae9db9d931f92a43a7315a6d0686fdb
https://doi.org/10.1016/s0960-894x(01)80853-2
https://doi.org/10.1016/s0960-894x(01)80853-2
Autor:
R. F. Bauer, P. W. Collins, B.S. Tsai, R H Keith, R. G. Bianchi, W E Perkins, Alan F. Gasiecki, Robert L. Shone
Publikováno v:
Prostaglandins. 44:579-595
Prostaglandin E (PGE) receptors in canine small intestinal mucosal and muscle membrane preparations were labeled with [3H] PGE1. Saturable, high affinity binding of [3H] PGE1 was observed in both preparations. The density of binding sites (fmol/mg pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b95bbe20dd017aafdfe15a8cc587cf
https://doi.org/10.1016/0090-6980(92)90026-p
https://doi.org/10.1016/0090-6980(92)90026-p
Autor:
D Villani-Price, B.S. Tsai, R H Keith, Stevan W. Djuric, Thomas D. Penning, Julie M. Miyashiro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:179-182
An enantioselective synthesis of a unique analogue of the pro-inflammatory eicosanoid Leukotriene B4 has been achieved in a convergent manner, from readily available starting materials. This analogue, 12-deoxy-12(S)-methyl LTB4, provides convincing e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b45e045ba8d30819dc0c387e2381a65d
https://doi.org/10.1016/s0960-894x(01)80795-2
https://doi.org/10.1016/s0960-894x(01)80795-2
Autor:
R. H. Keith, R. M. Hoover
Publikováno v:
Handbook of Noise and Vibration Control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37a45cf4e2607f6009dab64c82d413d
https://doi.org/10.1002/9780470172537.ch98
https://doi.org/10.1002/9780470172537.ch98
Autor:
B S, Tsai, R H, Keith, W E, Perkins, R E, Walsh, C P, Anglin, P W, Collins, A W, Gasiecki, R F, Bauer, P H, Jones, T S, Gaginella
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 275(1)
Prostaglandins (PGs) in the E-series exhibit potent gastric antisecretory activity, but can also cause diarrhea, which is mediated via PGE receptors. SC-46275, an omega-chain cyclopentenyl analog of the E-type PG enisoprost, was evaluated with other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c4ab637c2c25d71a5c5de327ef276d2
https://pubmed.ncbi.nlm.nih.gov/7562572
https://pubmed.ncbi.nlm.nih.gov/7562572
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
Previously, we reported that SC-41930 is a potent leukotriene B4 (LTB4) receptor antagonist. An analog of SC-41930, SC-51146, was evaluated as an antagonist of LTB4 receptors. SC-51146 was shown to bind to LTB4 high affinity binding sites on human ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f2fefdbc32672398f6e901a394e673f
https://pubmed.ncbi.nlm.nih.gov/8138960
https://pubmed.ncbi.nlm.nih.gov/8138960
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 268(3)
SC-45694 (7-[4-(1-hydroxy-3Z-nonenyl)phenyl]-5S-hydroxy-6Z-hept enoic acid lithium salt), a representative of a new class of leukotriene B4 (LTB4) analogs that are conformationally restricted, was evaluated for effects on human neutrophil functions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41e836fc1ff24acc43883f572d2aa253
https://pubmed.ncbi.nlm.nih.gov/8138959
https://pubmed.ncbi.nlm.nih.gov/8138959
Autor:
D. L. Widomski, D. Spangler, James F. Kachur, S. W. Djuric, D. J. Fretland, Stella S. Yu, Stephen H. Docter, R H Keith, D Villani-Price, T. D. Penning, B.S. Tsai, C. P. Anglin
Publikováno v:
Agents and actions.
SC-41930, 7-[3-(4-acetyl-3-methoxy-2-propylphenoxy)propoxy]-3,4- dihydro-8-propyl-2H-1-benzopyran-2-carboxylic acid, is a selective, orally active, LTB4 receptor antagonist currently in clinical trials for psoriasis and ulcerative colitis. Exhaustive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b2df225593f6b6bb3c6180d89a84cb
https://pubmed.ncbi.nlm.nih.gov/8273545
https://pubmed.ncbi.nlm.nih.gov/8273545