Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R H, Böcker"'
Publikováno v:
Pharmacologytoxicology. 85(6)
Trospium chloride, an atropine derivative used for the treatment of urge incontinence, was tested for inhibitory effects on human cytochrome P450 enzymes. Metabolic activities were determined in liver microsomes from two donors using the following se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cebf6921711e86d7f61972834529992
https://pubmed.ncbi.nlm.nih.gov/10628907
https://pubmed.ncbi.nlm.nih.gov/10628907
Autor:
C, Wandel, R H, Böcker, H, Böhrer, J X, deVries, W, Hofmann, K, Walter, B, Kleingeist, S, Neff, R, Ding, I, Walter-Sack, E, Martin
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(2)
It was recently shown by others that the clearance of midazolam/kg body weight after iv administration correlates with hepatic cytochrome P450 (CYP or P450) 3A content in liver transplant patients. However, after po administration midazolam undergoes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::38bfec341647be53d532bac009f20ced
https://pubmed.ncbi.nlm.nih.gov/9456296
https://pubmed.ncbi.nlm.nih.gov/9456296
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(8)
The in vitro metabolism of four s-triazine herbicides (atrazine, terbuthylazine, ametryne, and terbutryne) was studied using liver microsomes from rats, pigs, and humans. New HPLC methods with UV detection were developed for the analyses of the incub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8cb38a348070e343fcd86fa921e86f2b
https://pubmed.ncbi.nlm.nih.gov/8869820
https://pubmed.ncbi.nlm.nih.gov/8869820
Autor:
F P, Guengerich, R H, Böcker
Publikováno v:
The Journal of biological chemistry. 263(17)
A variety of different 4-substituted 1,4-dihydropyridine Hantzsch esters are substrates for ring dehydrogenation by a cytochrome P-450 (P-450) enzyme (P-450 UT-A); the substitutent could be varied from a hydrogen to a naphthalenyl, but a pyrenyl deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::be0569d59a9b1d0fe7da460568f3a7c5
https://pubmed.ncbi.nlm.nih.gov/3372517
https://pubmed.ncbi.nlm.nih.gov/3372517
Publikováno v:
The Journal of biological chemistry. 263(17)
Cytochrome P-450 (P-450)-catalyzed oxidation of 2,6-dimethyl-4-phenyl-3,5-pyridinedicarboxylic acid diethyl ester gives rise to 2,6-dimethyl-4-phenyl-3,5-pyridinedicarboxylic acid monoethyl ester and to 2-hydroxymethyl-6-methyl-4-phenyl-3,5-pyridined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::89d1679f6774e9f6b6d53736f1dea4e1
https://pubmed.ncbi.nlm.nih.gov/3372518
https://pubmed.ncbi.nlm.nih.gov/3372518
Autor:
R H Böcker, F P Guengerich
Publikováno v:
Journal of medicinal chemistry. 29(9)
4-Substituted 2,6-dimethyl-3,5-bis(alkoxycarbonyl)-1,4-dihydropyridines are important because of their roles as calcium channel blockers. The mixed-function oxidation of 14 4-aryl- and four 4-alkyl-substituted derivatives by human liver microsomes wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee01572b9ff1027443ad99873884cdc
https://pubmed.ncbi.nlm.nih.gov/3746811
https://pubmed.ncbi.nlm.nih.gov/3746811