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Akademický článek

Mucolytic treatment of chronic rhinosinusitis in a murine model of primary ciliary dyskinesia

Autor: Weining Yin, Hannah L. Golliher, Amy J. Ferguson, Julia S. Kimbell, Alessandra Livraghi-Butrico, Troy D. Rogers, Barbara R. Grubb, Adam J. Kimple, Lawrence E. Ostrowski

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Background: Genetic defects in motile cilia cause primary ciliary dyskinesia (PCD), a rare disease with no specific therapeutics. Individuals with PCD often have impaired fertility and laterality defects and universally suffer from upper and lower ai

Externí odkaz: https://doaj.org/article/7313cb29e11040f7ab3ac56f34fb3ca2

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Akademický článek

Regional Differences in Mucociliary Clearance in the Upper and Lower Airways

Autor: Troy D. Rogers, Brian Button, Samir N. P. Kelada, Lawrence E. Ostrowski, Alessandra Livraghi-Butrico, Mark I. Gutay, Charles R. Esther, Barbara R. Grubb

Publikováno v: Frontiers in Physiology, Vol 13 (2022)

As the nasal cavity is the portal of entry for inspired air in mammals, this region is exposed to the highest concentration of inhaled particulate matter and pathogens, which must be removed to keep the lower airways sterile. Thus, one might expect v

Externí odkaz: https://doaj.org/article/8f11df437d0b4e6cbc966594a58fd2c5

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Akademický článek

Multi-centre Randomised Controlled Trial of a Smartphone-based Event Recorder Alongside Standard Care Versus Standard Care for Patients Presenting to the Emergency Department with Palpitations and Pre-syncope: The IPED (Investigation of Palpitations in the ED) study

Autor: Matthew J. Reed, Neil R. Grubb, Christopher C. Lang, Rachel O'Brien, Kirsty Simpson, Mia Padarenga, Alison Grant, Sharon Tuck, Liza Keating, Frank Coffey, Lucy Jones, Tim Harris, Gavin Lloyd, James Gagg, Jason E. Smith, Tim Coats

Publikováno v: EClinicalMedicine, Vol 8, Iss , Pp 37-46 (2019)

Background: Patients with palpitations and pre-syncope commonly present to Emergency Departments (EDs) but underlying rhythm diagnosis is often not possible during the initial presentation. This trial compares the symptomatic rhythm detection rate of

Externí odkaz: https://doaj.org/article/08861aa74a7642c29fcced7b35e7ce7b

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Akademický článek

Multi-centre randomised controlled trial of a smart phone-based event recorder alongside standard care versus standard care for patients presenting to the Emergency Department with palpitations and pre-syncope - the IPED (Investigation of Palpitations in the ED) study: study protocol for a randomised controlled trial

Autor: Matthew J. Reed, Neil R. Grubb, Christopher C. Lang, Rachel O’Brien, Kirsty Simpson, Mia Padarenga, Alison Grant, Sharon Tuck

Publikováno v: Trials, Vol 19, Iss 1, Pp 1-9 (2018)

Abstract Background Palpitations and pre-syncope are together responsible for 300,000 annual Emergency Department (ED) attendances in the United Kingdom (UK). Diagnosis of the underlying rhythm is difficult as many patients are fully recovered on ED

Externí odkaz: https://doaj.org/article/59a564a092dd4ad0b4e13b0ccf0c86e7

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Akademický článek

Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene

Publikováno v: JCI Insight, Vol 6, Iss 1 (2021)

Existing animal models of cystic fibrosis (CF) have provided key insights into CF pathogenesis but have been limited by short lifespans, absence of key phenotypes, and/or high maintenance costs. Here, we report the CRISPR/Cas9-mediated generation of

Externí odkaz: https://doaj.org/article/ff264f8cd5104415abd1eba07591062e

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Akademický článek

Airway Epithelial Nucleotide Release Contributes to Mucociliary Clearance

Autor: Catharina van Heusden, Barbara R. Grubb, Brian Button, Eduardo R. Lazarowski

Publikováno v: Life, Vol 11, Iss 5, p 430 (2021)

Mucociliary clearance (MCC) is a dominant component of pulmonary host defense. In health, the periciliary layer (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force. Airway surface

Externí odkaz: https://doaj.org/article/22b9ca4970c1453d8e882a06125eda49

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'The More You Do, the More Comfortable You Feel': the Police Hostage and Crisis Negotiator Journey

Autor: Amy R. Grubb, Sarah J. Brown, Peter Hall, Erica Bowen

Publikováno v: Journal of Police and Criminal Psychology. 37:195-211

Hostage and crisis negotiators are specialist police officers utilised internationally by police forces to resolve hostage and crisis incidents. Whilst the role has been heavily documented in some parts of the world (namely the United States of Ameri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b74c35aa0cc685096f0ce518fb799d1
https://doi.org/10.1007/s11896-021-09486-3

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Akademický článek

Brain natriuretic peptide and high-sensitivity Troponin at 3 hours post emergency department attendance with unexplained syncope predict 90 day outcome

Autor: Matthew James Reed, Hannah Brutin, Neil R. Grubb, Christopher C. Lang, Alasdair J. Gray, Kirsty Simpson, Allan MacRaild, Christopher J. Weir

Publikováno v: Emergency Care Journal, Vol 14, Iss 2 (2018)

To investigate if Brain Natriuretic Peptide (BNP) and highsensitivity troponin I predict significant arrhythmia, symptomatic significant arrhythmia and 90-day death and/or Major Adverse Cardiac Event in Emergency Department (ED) unexplained syncope p

Externí odkaz: https://doaj.org/article/b0bfbe54da5a4d88b2acc57e7ddfdee8

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