Zobrazeno 1 - 10
of 509
pro vyhledávání: '"R Greaves"'
Publikováno v:
Cells, Vol 13, Iss 11, p 916 (2024)
Acute inflammation is a rapid and dynamic process involving the recruitment and activation of multiple cell types in a coordinated and precise manner. Here, we investigate the origin and transcriptional reprogramming of monocytes using a model of acu
Externí odkaz:
https://doaj.org/article/e62c6d9c98204d12b01a2a8f4ddda00c
Autor:
Savita Devi, Mohanalaxmi Indramohan, Elisabeth Jäger, Jessica Carriere, Lan H. Chu, Lucia de Almeida, David R. Greaves, Christian Stehlik, Andrea Dorfleutner
Publikováno v:
Cell Reports, Vol 42, Iss 3, Pp 112265- (2023)
Summary: Inflammatory responses are crucial for controlling infections and initiating tissue repair. However, excessive and uncontrolled inflammation causes inflammatory disease. Processing and release of the pro-inflammatory cytokines interleukin-1
Externí odkaz:
https://doaj.org/article/356acb21046a4a7d9e2a97a5f2b82fc3
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Drug repurposing is an attractive, pragmatic approach to drug discovery that has yielded success across medical fields over the years. The use of existing medicines for novel indications enables dramatically reduced development costs and timescales c
Externí odkaz:
https://doaj.org/article/f8bc95d6494c4983b82bfebf5b7f2dca
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Current genetic tools designed to target macrophages in vivo often target cells from all myeloid lineages. Therefore, we sought to generate a novel transgenic mouse which has a tamoxifen inducible Cre-recombinase under the control of the human CD68 p
Externí odkaz:
https://doaj.org/article/dd662b0923cb409f976ef20ba425de8f
Autor:
Filipa C. Simões, Thomas J. Cahill, Amy Kenyon, Daria Gavriouchkina, Joaquim M. Vieira, Xin Sun, Daniela Pezzolla, Christophe Ravaud, Eva Masmanian, Michael Weinberger, Sarah Mayes, Madeleine E. Lemieux, Damien N. Barnette, Mala Gunadasa-Rohling, Ruth M. Williams, David R. Greaves, Le A. Trinh, Scott E. Fraser, Sarah L. Dallas, Robin P. Choudhury, Tatjana Sauka-Spengler, Paul R. Riley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Macrophages mediate the fibrotic response after a heart attack by extracellular matrix turnover and cardiac fibroblasts activation. Here the authors identify an evolutionarily-conserved function of macrophages that contributes directly to the forming
Externí odkaz:
https://doaj.org/article/edf55153a7b34a528c084339f4ceeac3
Autor:
Eileen McNeill, Elena Stylianou, Mark J. Crabtree, Rachel Harrington-Kandt, Anna-Lena Kolb, Marina Diotallevi, Ashley B. Hale, Paulo Bettencourt, Rachel Tanner, Matthew K. O’Shea, Magali Matsumiya, Helen Lockstone, Julius Müller, Helen A. Fletcher, David R. Greaves, Helen McShane, Keith M. Channon
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Inducible nitric oxide (NO) synthase (iNOS) is essential in the response to mycobacterial infection, yet NOS signalling can occur through NO-dependent or NO-independent pathways. Here the authors show macrophage Gch1 and tetrahydrobiopterin mediate N
Externí odkaz:
https://doaj.org/article/6b10bf22d1cf44e59fc4465f802a33e8
Autor:
Cynthia A. Reddick, June R. Greaves, Janelle E. Flaherty, Lindsey E. Callihan, Cara H. Larimer, Sarah A. Allen
Publikováno v:
Nutrition in Clinical Practice. 38:216-239
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ca7c4457b25a7ca42536b7a2c375b5
https://doi.org/10.1002/ncp.10959
https://doi.org/10.1002/ncp.10959
Autor:
Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection again
Externí odkaz:
https://doaj.org/article/931268b411324e2c8343ed117a290152
Publikováno v:
Biology, Vol 11, Iss 3, p 372 (2022)
NF-κB is a central mediator of inflammation, response to DNA damage and oxidative stress. As a result of its central role in so many important cellular processes, NF-κB dysregulation has been implicated in the pathology of important human diseases.
Externí odkaz:
https://doaj.org/article/5d653b31a7354285ae2665a92c753503
Autor:
Rojo A. Ratsimandresy, Lan H. Chu, Sonal Khare, Lucia de Almeida, Anu Gangopadhyay, Mohanalaxmi Indramohan, Alexander V. Misharin, David R. Greaves, Harris Perlman, Andrea Dorfleutner, Christian Stehlik
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Excessive inflammasome activation leads to inflammatory diseases, but how inflammasomes are regulated by PYD-only adaptors is unclear. Here the authors show that the PYD-only protein POP2 inhibits both inflammasome priming and assembly by interfering
Externí odkaz:
https://doaj.org/article/28458afcf61a49ae89fbff053e45bdf4