Zobrazeno 1 - 10
of 17
pro vyhledávání: '"R Garrett Morgan"'
Autor:
R Garrett Morgan, Massimo Venturelli, Cole Gross, Cantor Tarperi, Federico Schena, Carlo Reggiani, Fabio Naro, Anna Pedrinolla, Lucia Monaco, Russell S Richardson, Anthony J Donato
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169628 (2017)
ALU element instability could contribute to gene function variance in aging, and may partly explain variation in human lifespan.To assess the role of ALU element instability in human aging and the potential efficacy of ALU element content as a marker
Externí odkaz:
https://doaj.org/article/70ab5fccc38e47468cb629b4ef92117c
Autor:
R. Garrett Morgan, Lisa A. Lesniewski, Tam T. T. Phuong, Yu Liu, Daniel R. Machin, Kelly D. Reihl, Russell S. Richardson, Grant D. Henson, Daniel W. Trott, Eros Lazzerini Denchi, Samuel I. Bloom, Richard M. Cawthon, Anthony J. Donato, Ashley E. Walker
Publikováno v:
J Mol Cell Cardiol
Age-related vascular dysfunction in large elastic and resistance arteries is associated with reductions in microvascular perfusion and elevations in blood pressure. Recent evidence indicates that telomere uncapping-induced senescence in vascular cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::343bec0ed9f8958bbe9d28f0d4d83a6b
https://doi.org/10.1016/j.yjmcc.2018.11.014
https://doi.org/10.1016/j.yjmcc.2018.11.014
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 315:H1-H5
Although most telomere biology research continues to focus on telomere shortening, there is increasing evidence that telomere deprotection, or “uncapping,” is more biologically and possibly clinically important. Telomeres form t-loops to prevent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea3df01893bdafb62c9b68a3ea8e03c
https://doi.org/10.1152/ajpheart.00008.2018
https://doi.org/10.1152/ajpheart.00008.2018
Autor:
Anthony J. Donato, R. Garrett Morgan, Stephen J. Ives, Sugata Hazra, Sarah R. Breevoort, Russell S. Richardson, Grant D. Henson, Lisa A. Lesniewski
Publikováno v:
Experimental Gerontology. 83:165-170
MicroRNAs (miRs) are small non-coding RNAs that are important regulators of aging and cardiovascular diseases. MiR-92a is important in developmental vascular growth and tumorigenesis and two of its putative targets, tumor necrosis factor alpha recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c4b4ecf118e2a84576ac376a43e7e7
https://doi.org/10.1016/j.exger.2016.08.007
https://doi.org/10.1016/j.exger.2016.08.007
Autor:
Stephen J. Ives, Dirk Noyes, Lisa A. Lesniewski, Ashley E. Walker, R. Garrett Morgan, Robert H.I. Andtbacka, Anthony J. Donato, Russell S. Richardson, Richard M. Cawthon
Publikováno v:
Experimental Gerontology. 73:65-71
Recently, it has been recognized that human skeletal muscle feed arteries can be harvested during exploratory surgery for melanoma. This approach provides vessels for in vitro study from a wide spectrum of relatively healthy humans. Although, the reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00cf3d95ba6680033c24966d55ae596a
https://doi.org/10.1016/j.exger.2015.11.009
https://doi.org/10.1016/j.exger.2015.11.009
Publikováno v:
Journal of Molecular and Cellular Cardiology. 89:122-135
Cardiovascular disease (CVD) is the leading cause of death in the United States and aging is a major risk factor for CVD development. One of the major age-related arterial phenotypes thought to be responsible for the development of CVD in older adult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952b5cfeafe584de3c6a630eee30ae4a
https://doi.org/10.1016/j.yjmcc.2015.01.021
https://doi.org/10.1016/j.yjmcc.2015.01.021
Autor:
R. Garrett Morgan
Publikováno v:
Circulation Research. 121:200-202
Mendelian randomization study designs represent new powerful tools available to researchers that enable causal inferences to be made about the effects of risk factors in health and disease outcomes in the context of a prospective observational study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cfa43444cfec4511ad5e98802e0db06
https://doi.org/10.1161/circresaha.117.311387
https://doi.org/10.1161/circresaha.117.311387
Autor:
C. Dirk Keene, Emily Sherfield, Nadia Postupna, Richard D. Palmiter, Angela M. Wilson, Erica J. Melief, R. Garrett Morgan, Jeffrey T. Gibbs, Thomas J. Montine, Martin Darvas
Publikováno v:
Experimental Neurology. 271:205-214
Parkinson's disease (PD) is characterized by the loss of dopaminergic neurons and produces a movement disorder and cognitive impairment that becomes more extensive with the duration of the disease. To what extent cognitive impairment in advanced PD c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c98ea00ceabca737bdcf680b29f4e858
https://doi.org/10.1016/j.expneurol.2015.06.013
https://doi.org/10.1016/j.expneurol.2015.06.013
Autor:
Parker S. Dobson, Ashley E. Walker, Anthony J. Donato, Robert P. Mecham, Dean Y. Li, Grant D. Henson, Lisa A. Lesniewski, R. Garrett Morgan, Elizabeth I. Nielson, Jing Ling, Kelly D. Reihl
Publikováno v:
The Journal of Physiology. 593:1931-1943
Key points Increased large artery stiffness is a hallmark of arterial dysfunction with advancing age and is also present in other disease conditions such as diabetes. Increased large artery stiffness is correlated with resistance artery dysfunction i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::828d42db932d3e15ad95a71f3c064f7c
https://doi.org/10.1113/jphysiol.2014.285338
https://doi.org/10.1113/jphysiol.2014.285338
Autor:
Anthony J. Donato, Anna Pedrinolla, R. Garrett Morgan, Cantor Tarperi, Cole Gross, Russell S. Richardson, Lucia Monaco, Carlo Reggiani, Fabio Naro, Federico Schena, Massimo Venturelli
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169628 (2017)
PLoS ONE
PLoS ONE
BACKGROUND ALU element instability could contribute to gene function variance in aging, and may partly explain variation in human lifespan. OBJECTIVE To assess the role of ALU element instability in human aging and the potential efficacy of ALU eleme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::139591afb06183dc460f2f6714376672
http://europepmc.org/articles/PMC5218400?pdf=render
http://europepmc.org/articles/PMC5218400?pdf=render