Zobrazeno 1 - 10
of 44
pro vyhledávání: '"R G Moran"'
Publikováno v:
JNCI Journal of the National Cancer Institute. 85:1154-1159
Background Cancer chemotherapy with folate antimetabolites has been traditionally targeted at the enzyme dihydrofolate reductase and is based on the requirement of dividing tumor cells for a supply of thymidylate and purines. However, a new compound,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926c81a10afef09f447f9c5479b18bb2
https://doi.org/10.1093/jnci/85.14.1154
https://doi.org/10.1093/jnci/85.14.1154
Publikováno v:
Advances in Enzyme Regulation. 31:13-27
Heterocyclic para-aminobenzoate modifications of 2-desamino-2-methyl-5,8-dideazafolic acid and a series of its N10-substituted analogs have produced a number of interesting compounds that have enabled a deeper understanding of the biochemical events
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6c67404ca23a96fab07a73ba123b3a
https://doi.org/10.1016/0065-2571(91)90006-8
https://doi.org/10.1016/0065-2571(91)90006-8
Autor:
S A, Titus, R G, Moran
Publikováno v:
The Journal of biological chemistry. 275(47)
The transduction of a human placental cDNA retroviral library into glyB cells, a Chinese hamster ovary K1 subline that is deficient in the transport of folates into mitochondria, resulted in the complementation of glycine auxotrophy of these cells. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c81515341ffd81c1af2e40eb25bd1a04
https://pubmed.ncbi.nlm.nih.gov/10978331
https://pubmed.ncbi.nlm.nih.gov/10978331
Publikováno v:
Cancer research. 59(24)
Folates and folate antimetabolites are metabolically trapped in mammalian cells as polyglutamates, a process catalyzed by folylpoly-gamma-glutamate synthetase (FPGS). Using 5'-rapid amplification of cDNA ends, RNase protection assays, transfection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::50bf6949c3f1533dd93462b48efeaa6a
https://pubmed.ncbi.nlm.nih.gov/10626793
https://pubmed.ncbi.nlm.nih.gov/10626793
Autor:
R G, Moran
Publikováno v:
Seminars in oncology. 26(2 Suppl 6)
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs. Folylpoly-gamma-glutamate synthetase has three functions in fola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0e396d397bae0ca21d46b5b1dfdeeedf
https://pubmed.ncbi.nlm.nih.gov/10598551
https://pubmed.ncbi.nlm.nih.gov/10598551
Autor:
A, Tse, R G, Moran
Publikováno v:
The Journal of biological chemistry. 273(40)
Mouse L1210 cell variants were selected for resistance to 5, 10-dideazatetrahydrofolate, a potent inhibitor of the first folate-dependent enzyme in de novo purine synthesis, glycinamide ribonucleotide formyltransferase. The drug-resistant phenotype s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::aa7e7dbdd5608953d6a6fd4352d71c05
https://pubmed.ncbi.nlm.nih.gov/9748271
https://pubmed.ncbi.nlm.nih.gov/9748271
Publikováno v:
Cancer research. 56(10)
Recent clinical trials with lometrexol [(6R)-5,10-dideazatetrahydrofolate] have revealed a level of toxicity in humans that was not predicted on the basis of previous in vivo preclinical studies. Because standard laboratory animal diets contain high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d85bf4dba483e15c8ea43c1836c8c4e9
https://pubmed.ncbi.nlm.nih.gov/8625328
https://pubmed.ncbi.nlm.nih.gov/8625328
Publikováno v:
Cancer research. 55(24)
The cytotoxicity, and probably the selectivity, of folate antimetabolites depend upon the expression of the enzyme folylpoly-gamma-glutamate synthetase in tumor cells. Evidence for the existence of multiple forms of this enzyme and the need to define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36a678b5249dba0469f3e4cfb43a2c9c
https://pubmed.ncbi.nlm.nih.gov/8521387
https://pubmed.ncbi.nlm.nih.gov/8521387
Autor:
L L, Habeck, L G, Mendelsohn, C, Shih, E C, Taylor, P D, Colman, L S, Gossett, T A, Leitner, R M, Schultz, S L, Andis, R G, Moran
Publikováno v:
Molecular pharmacology. 48(2)
The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent. The availability of a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9ed8e094b41fc87a70247abc4f91956c
https://pubmed.ncbi.nlm.nih.gov/7651366
https://pubmed.ncbi.nlm.nih.gov/7651366
Publikováno v:
Molecular pharmacology. 45(2)
Previous attempts to design inhibitors of mammalian folylpolyglutamate synthetase (FPGS) have resulted in three classes of active compounds, all of which have charged moieties in the side chain, but structural alteration of the rest of the folate mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2da7248d353fb89ae5cdc6ef7da38da3
https://pubmed.ncbi.nlm.nih.gov/8114682
https://pubmed.ncbi.nlm.nih.gov/8114682