Zobrazeno 1 - 10 of 19 pro vyhledávání: '"R G Leslie"'
1
Diabetes Mellitus 2014
Autor: Helen Vlassara, Anastasia N. Mavrogiannaki, Ilias Migdalis, Nikolaos Papanas, Paul Valensi, D. R. G. Leslie
Publikováno v: International Journal of Endocrinology, Vol 2015 (2015)
International Journal of Endocrinology
The ongoing progress in diabetes mellitus is reflected in new treatment algorithms [1], new oral hypoglycaemic agents [2], new tests for the early diagnosis of complications [3], and improved organisation of healthcare resources [4]. The present spec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57881fe9d2b8c8d07e4a9a285b468ab6
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3
CR2 is the primary acceptor site for C3 during alternative pathway activation of complement on human peripheral B lymphocytes
Autor: H V Marquart, S E Svehag, R G Leslie
Publikováno v: The Journal of Immunology. 153:307-315
Human cells infected with certain viruses acquire the ability to activate the alternative pathway (AP) of complement. Complement receptor 2 on EBV-infected lymphoblastoid cell lines has been reported to act as the covalent binding site for C3b during
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::091c639161673dc7abc1f57977a2ed8c
https://doi.org/10.4049/jimmunol.153.1.307
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4
Natural autoantibodies and complement promote the uptake of a self antigen, human thyroglobulin, by B cells and the proliferation of thyroglobulin-reactive CD4(+) T cells in healthy individuals
Autor: C H, Nielsen, R G, Leslie, B S, Jepsen, M D, Kazatchkine, S V, Kaveri, E, Fischer
Publikováno v: European journal of immunology. 31(9)
Serum from normal individuals contains substantial amounts of natural antibodies (NA) capable of recognizing self antigens. However, the physiological implications of this autoreactivity remain unclear. We have examined the role of self-reactive NA a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ee64d564bf8e17a2c4d0f957cd1a70d
https://pubmed.ncbi.nlm.nih.gov/11536164
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5
The role of complement in the acquired immune response
Autor: C H, Nielsen, E M, Fischer, R G, Leslie
Publikováno v: Immunology. 100(1)
Studies over the past three decades have clearly established a central role for complement in the promotion of a humoral immune response. The primary function of complement, in this regard, is to opsonize antigen or immune complexes for uptake by com
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9bfead04c321e3ece71b13c5fda6177
https://pubmed.ncbi.nlm.nih.gov/10809953
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6
The structural basis for complement receptor type 2 (CR2, CD21)-mediated alternative pathway activation of complement: studies with CR2 deletion mutants and vaccinia virus complement-control protein-CR2 chimeras
Autor: A A, Johnson, A, Mirowski Rosengard, K, Skjodt, J M, Ahearn, R G, Leslie
Publikováno v: European journal of immunology. 29(12)
The role of complement receptor 2 (CR2) short consensus repeats (SCR) in binding of hydrolyzed C3 (iC3) to form an alternative pathway (AP) convertase, and promoting C3 fragment deposition following AP activation, was examined. We used (1) K562 cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::262bcfb936fcf3b80593eef88f00966f
https://pubmed.ncbi.nlm.nih.gov/10601991
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7
The requirement of localized, CR2-mediated, alternative pathway activation of complement for covalent deposition of C3 fragments on normal B cells
Autor: E H, Olesen, A A, Johnson, G, Damgaard, R G, Leslie
Publikováno v: Immunology. 93(2)
We have shown previously that normal B cells share, with Epstein-Barr virus-transformed and malignant B cells, the ability to activate the alternative pathway (AP) of complement in vitro, resulting in the deposition of C3 fragments on the cell surfac
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::665db1411218e39681870cf06c1392e6
https://pubmed.ncbi.nlm.nih.gov/9616366
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8
Diminished ability of erythrocytes from patients with systemic lupus erythematosus to limit opsonized immune complex deposition on leukocytes and activation of granulocytes
Autor: C H, Nielsen, J M, Rasmussen, A, Voss, P, Junker, R G, Leslie
Publikováno v: Arthritis and rheumatism. 41(4)
To compare the ability of normal erythrocytes and erythrocytes from systemic lupus erythematosus (SLE) patients to bind immune complexes (IC), thereby inhibiting IC deposition on polymorphonuclear leukocytes (PMN) and the consequent induction of a PM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d1f14c4e5ca1a6de293b78658966eeca
https://pubmed.ncbi.nlm.nih.gov/9550470
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10
Cytophilic activity of IgG2 from sera of guinea-pigs immunized with bovine gamma-globulin
Autor: R G, Leslie, S, Cohen
Publikováno v: Immunology. 27(4)
IgG2 from immune guinea-pig sera collected 1-2 weeks after secondary BGG challenge showed considerably enhanced cytophilic activity; the preparations contained aggregates (±10 per cent of the total immunoglobulin) shown by antigen exchange to be imm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b72c4aa7294d9adbff043c5a7e261abf
https://pubmed.ncbi.nlm.nih.gov/4140145
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