Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R G, van Amsterdam"'
Publikováno v:
Thrombosis and haemostasis. 84(4)
Org 36764, is an antithrombin III (AT) and thrombin binding carbohydrate, which accelerates the inactivation of both factor Xa and thrombin by AT. It displays in buffer an anti-Xa and anti-thrombin activity of 415 and 2 U/mg, respectively, compared t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2daa675c955a557defd4d4ce0805a1ed
https://pubmed.ncbi.nlm.nih.gov/11057859
https://pubmed.ncbi.nlm.nih.gov/11057859
Autor:
J M, Herbert, J P, Hérault, A, Bernat, R G, van Amsterdam, J C, Lormeau, M, Petitou, C, van Boeckel, P, Hoffmann, D G, Meuleman
Publikováno v:
Blood. 91(11)
SANORG 34006 is a new sulfated pentasaccharide obtained by chemical synthesis. It is an analog of the "synthetic pentasaccharide" (SR 90107/ ORG 31540) which represents the antithrombin (AT) binding site of heparin. SANORG 34006 showed a higher affin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c4e5fccbe652bf0d53387986c5879b87
https://pubmed.ncbi.nlm.nih.gov/9596667
https://pubmed.ncbi.nlm.nih.gov/9596667
Autor:
G M, Vogel, R G, van Amsterdam, P, Zandberg, P, van Houwelingen, W J, Kop, F W, van Mensvoort, D G, Meuleman
Publikováno v:
Thrombosis and haemostasis. 77(1)
Two thrombosis models in rats are described in which mixed type thrombi are formed at arterial and venous flow rates. The models, containing a silk thread in the aorta and vena cava, respectively, were characterised for the activity of three platelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b57f9094389923a396d83f344100e025
https://pubmed.ncbi.nlm.nih.gov/9031471
https://pubmed.ncbi.nlm.nih.gov/9031471
Autor:
C D, Nicholson, M, Shahid, J, Bruin, E, Barron, I, Spiers, J, de Boer, R G, van Amsterdam, J, Zaagsma, J J, Kelly, G, Dent
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 274(2)
The pharmacological profile of a novel cyclic nucleotide phosphodiesterase (PDE) inhibitor, Org 20241, has been characterized. The compound selectively inhibits PDE IV (pIC50, 5.2-6.1) and PDE III (pIC50, 4.4-4.6) from animal and human tissues. Org 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e475d0b804abb3765fd8f2845775b147
https://pubmed.ncbi.nlm.nih.gov/7636728
https://pubmed.ncbi.nlm.nih.gov/7636728
Publikováno v:
Thrombosis and haemostasis. 69(1)
The mode of action of glycosaminoglycans (GAGs) towards thrombus formation in a rat arteriovenous shunt was studied by simultaneous examination of thrombus weight, platelet consumption and thrombin generation during 45 min of blood circulation. A com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d3f695e89c1d97882d5f1bde3b72af25
https://pubmed.ncbi.nlm.nih.gov/8446935
https://pubmed.ncbi.nlm.nih.gov/8446935
Publikováno v:
Pharmaceutical research. 8(10)
Low molecular weight proteins (LMWPs), such as lysozyme, may be suitable carriers to target drugs to the kidney. In this study the antiinflammatory drug naproxen was covalently bound to lysozyme (1:1). Pharmacokinetics of the conjugate, naproxen-lyso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1262c492a6a2564be26424db893ca6af
https://pubmed.ncbi.nlm.nih.gov/1796038
https://pubmed.ncbi.nlm.nih.gov/1796038