Zobrazeno 1 - 10
of 30
pro vyhledávání: '"R G, Wickremasinghe"'
Autor:
Martin J. Humphries, R. G. Wickremasinghe, S. B. Kanner, I. E. Collins, N. Amft, Tony Ng, K. E. Nye, W. J. W. Morrow, D. D'cruz
Publikováno v:
Lupus. 8:39-51
Objective: To establish the relationship between T cell responses to integrin coreceptor stimulation and B cell hyperreactivity as measured by pathologic autoantibody production.Methods: Peripheral blood mononuclear cells from 42 patients with SLE ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79c06c6af8b67c36691c47052f2b08fe
https://doi.org/10.1191/096120399678847371
https://doi.org/10.1191/096120399678847371
Autor:
R G Wickremasinghe, F A Riordan
Publikováno v:
Hematology. 3:387-396
The Philadelphia chromosomes characteristic of chronic myeloid leukemia (CML) and Philadelphia-positive acute lymphoblastic leukemia (ALL) encode chimeric protein tyrosine kinases (PTKs) derived by fusion of the normal BCR and ABL genes. The oncogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba7cb232e0d0a93d0dfae454c11cd7bd
https://doi.org/10.1080/10245332.1998.11746413
https://doi.org/10.1080/10245332.1998.11746413
Publikováno v:
Leukemia. 25(9)
The p53 tumor suppressor protein has a key role in the induction of apoptosis of chronic lymphocytic leukemia (CLL) cells. Abnormalities within the p53 pathway identify a subset of patients with a poor prognosis. This review describes recent advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54bd8285e1438ee16d0b812ff14e3a3
https://pubmed.ncbi.nlm.nih.gov/21566651
https://pubmed.ncbi.nlm.nih.gov/21566651
Publikováno v:
Oncology reports. 14(4)
The gastrin CCK2 pathway has been implicated in the development of various cancers including leukaemia. An autocrine or intracrine pathway may exist in the leukaemia cell that is involved in stimulating proliferation. We tested four leukaemia cell li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1503aa5ebb2af96f73076312b40845a
https://pubmed.ncbi.nlm.nih.gov/16142371
https://pubmed.ncbi.nlm.nih.gov/16142371
Autor:
R G, Wickremasinghe, K, Ganeshaguru, D T, Jones, C, Lindsay, V J, Spanswick, J A, Hartley, M, Wadhwa, R, Thorpe, A V, Hoffbrand, H G, Prentice, A B, Mehta
Publikováno v:
British journal of haematology. 114(3)
We have studied the actions of autologous plasma on both basal and DNA damage-induced apoptosis in B-chronic lymphocytic leukaemia (B-CLL) cells. Apoptosis was quantified using morphological criteria and Western blot analysis for the apoptosis-specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d23a2422f5a7a833dfa83787ad043f22
https://pubmed.ncbi.nlm.nih.gov/11552986
https://pubmed.ncbi.nlm.nih.gov/11552986
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 162(3)
We have investigated the molecular mechanisms underlying the ability of peripheral blood monocytes to block apoptosis induction in endothelial cells. Monocytes stimulated the expression of the bcl-2 homologue A1 in serum-starved endothelial cells aft
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::082bb0cb25db9d38095c60035b4ffaa2
https://pubmed.ncbi.nlm.nih.gov/9973392
https://pubmed.ncbi.nlm.nih.gov/9973392
Publikováno v:
British journal of haematology. 90(2)
Chromosomal abnormalities are detected by conventional cytogenetic or FISH analysis in 50% of chronic lymphocytic leukaemias (CLL). Trisomy 12 and del 13q14 account for 70% of these abnormalities. The incidence of these two abnormalities was studied
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ed54346ee67a18e5e45d00711d9f3ca6
https://pubmed.ncbi.nlm.nih.gov/7794777
https://pubmed.ncbi.nlm.nih.gov/7794777
Publikováno v:
Leukemialymphoma. 18(1-2)
B chronic lymphocytic leukemia (B-CLL) and hairy cell leukemia (HCL) cells are refractory to many of the signals which activate normal B cells but are stimulated to proliferate by tumor necrosis factor (TNF). Cell signalling by TNF is mediated in par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efa3a457325ada9c05b37e952067fe9d
https://pubmed.ncbi.nlm.nih.gov/8580820
https://pubmed.ncbi.nlm.nih.gov/8580820
Publikováno v:
Leukemia. 8(10)
Inositol 1,4,5-triphosphate (IP3) and inositol 1,3,4,5-tetrakisphosphate (IP4) are calcium-regulating second messenger molecules generated following the binding of a wide range of hormones and growth factors to their receptors. The actions of these m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6f5898c0e47608e354a433c5214fc390
https://pubmed.ncbi.nlm.nih.gov/7934169
https://pubmed.ncbi.nlm.nih.gov/7934169
Publikováno v:
Leukemia research. 18(7)
B-chronic lymphocytic leukaemia (B-CLL) and hairy cell leukaemia cells (HCL) are refractory to stimulation by several cytokines which activate normal B-cells. However, tumour necrosis factor (TNF) promotes the proliferation of these cells. TNF regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::350d500281aa1aef09eafa397b7c14eb
https://pubmed.ncbi.nlm.nih.gov/8022202
https://pubmed.ncbi.nlm.nih.gov/8022202