Výsledky vyhledávání

Disposition of [14C]velnacrine maleate in rats, dogs, and humans

Autor: R G, Turcan, D, Hillbeck, T E, Hartley, P J, Gilbert, R A, Coe, J A, Troke, C W, Vose

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 21(6)

This study describes the disposition of [14C]velnacrine maleate in rats, dogs, and humans, and the isolation and identification of metabolites in dog urine. Following oral administration of [14C]velnacrine maleate, drug-related material was well abso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::369f4f38674b4d97ff73f80d542c95da
https://pubmed.ncbi.nlm.nih.gov/7905382

Zobrazit plný text záznamu

Application of 19F-n.m.r. spectroscopy to the identification of dog urinary metabolites of imirestat, a spirohydantoin aldose reductase inhibitor

Autor: P. J. Gilbert, C. W. Vose, T. E. Hartley, R. G. Turcan, J. A. Troke, K. V. Watson

Publikováno v: Xenobiotica; the fate of foreign compounds in biological systems. 22(7)

1. Urine from a dog dosed orally at 20 mg/kg with 14C-imirestat, a spirohydantoin aldose reductase inhibitor, contained 17.7 and 12.5% of the administered radioactivity at 0-48 and 48-72 h respectively. 2. Radio-h.p.l.c. of the 0-48 h urine revealed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df21dffb7d924dad16632e4332e9ed0e
https://pubmed.ncbi.nlm.nih.gov/1455900

Zobrazit plný text záznamu

Inhibition of the rate of 14CO2 production from [14C]ethanol in rats given beta-lactam antibiotics with disulfiram-like effects

Autor: R. M. J. Ings, R. G. Turcan, J. D. Coombes, C. M. Macdonald

Publikováno v: Antimicrobial Agents and Chemotherapy. 27:535-540

An animal model has been developed to investigate the potentials of various beta-lactam antibiotics for inducing (or producing) disulfiram-like effects. The method, which measures the rate of 14CO2 production in rats after [14C]ethanol administration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cf7b96d542a27e490d3382c341321ee
https://doi.org/10.1128/aac.27.4.535

Zobrazit plný text záznamu

Hepatic microsomal drug metabolism in the pregnant rat

Autor: R. G. Turcan, A. M. Symons, Dennis V. Parke

Publikováno v: Xenobiotica. 12:365-374

1. Hepatic microsomal drug metabolism determined with the substrates aniline (p-hydroxylation), ethylmorphine (N-demethylation) and p-nitrobenzoic acid (reduction), decreased during gestation in the rat to 53-73% of non-pregnant control levels by day

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376bd823f539577ab676cfa21e744342
https://doi.org/10.3109/00498258209052477

Zobrazit plný text záznamu