Zobrazeno 1 - 10
of 10
pro vyhledávání: '"R G, Tirona"'
Autor:
C. R. A. Silveira, J. MacKinley, K. Coleman, Z. Li, E. Finger, R. Bartha, S. A. Morrow, J. Wells, M. Borrie, R. G. Tirona, C. A. Rupar, G. Zou, R. A. Hegele, D. Mahuran, P. MacDonald, M. E. Jenkins, M. Jog, S. H. Pasternak
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-10 (2019)
Abstract Background Currently there are no disease-modifying treatments for Parkinson’s disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the leading genetic risk f
Externí odkaz:
https://doaj.org/article/39756e13e96e452183057954edee2fa5
Autor:
Michael Borrie, C. R.A. Silveira, Robert A. Hegele, Jennie Wells, J. MacKinley, Penny A. MacDonald, Mandar Jog, Mary E. Jenkins, Don J. Mahuran, Stephen H. Pasternak, C. A. Rupar, Sarah A. Morrow, Kristy Coleman, Robert Bartha, Elizabeth Finger, R. G. Tirona, Guangyong Zou, Z. Li
Publikováno v:
BMC Neurology, Vol 19, Iss 1, Pp 1-10 (2019)
Medical Biophysics Publications
BMC Neurology
Medical Biophysics Publications
BMC Neurology
© 2019 The Author(s). Background: Currently there are no disease-modifying treatments for Parkinson's disease dementia (PDD), a condition linked to aggregation of the protein α-synuclein in subcortical and cortical brain areas. One of the leading g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f846bf4a3d9f36571dbad625b1f012bd
https://doi.org/10.1186/s12883-019-1252-3
https://doi.org/10.1186/s12883-019-1252-3
Publikováno v:
The Journal of biological chemistry. 276(38)
The human organic anion transporting polypeptide-C (OATP-C) (gene SLC21A6) is a liver-specific transporter importantly involved in the hepatocellular uptake of a variety of endogenous and foreign chemicals. In this study, we demonstrate the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80789a9498fa8da62ca45d1a17b287f3
https://pubmed.ncbi.nlm.nih.gov/11477075
https://pubmed.ncbi.nlm.nih.gov/11477075
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 291(3)
We assessed the impact of zonal factors on the hepatic reduced glutathione (GSH) conjugation of ethacrynic acid (EA). Uptake of EA by enriched periportal (PP) and perivenous (PV) rat hepatocytes was characterized by both saturable (V(max)(uptake) = 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fd3288d90baaa3c888f3487a362161ea
https://pubmed.ncbi.nlm.nih.gov/10565844
https://pubmed.ncbi.nlm.nih.gov/10565844
Autor:
R G, Tirona, K S, Pang
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 290(3)
The conjugation kinetics of glutathione (GSH) and ethacrynic acid (EA) were studied in rat liver perfusion studies, where efficient removal occurred (steady-state extraction ratio E(ss), approximately 0.8-0.4 at concentrations ranging from 10-200 mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b2a28e9702226bc151def6d89f08e6b2
https://pubmed.ncbi.nlm.nih.gov/10454499
https://pubmed.ncbi.nlm.nih.gov/10454499
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(3)
The zonal uptake of estrone sulfate (E1S; 1 to 400 microM) was investigated in periportal and perivenous rat hepatocytes and cells isolated from whole liver (regular hepatocytes). Transport of E1S by periportal, perivenous, and regular hepatocytes wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0feb5e5c49daeb02fbc7b509146fbc65
https://pubmed.ncbi.nlm.nih.gov/10064563
https://pubmed.ncbi.nlm.nih.gov/10064563
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(5)
The multiple indicator dilution (MID) technique is often used for investigation of the kinetic behavior of substrates and metabolites in eliminating organs. The present study was a systematic comparison of the utility of the Goresky model (GM) (a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::32d4f26b83bc020c07eb420c24c67f14
https://pubmed.ncbi.nlm.nih.gov/9571228
https://pubmed.ncbi.nlm.nih.gov/9571228
Autor:
S, Ouwerkerk-Mahadevan, R G, Tirona, R A, Ripping, J H, Ploemen, P J, van Bladeren, K S, Pang, J H, van Boom, G J, Mulder
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(10)
To assess the role of GST's (glutathione S-transferases) in the (de)toxification of their substrates, an in vivo active inhibitor based on the structure of glutathione (GSH), gamma-L-glutamyl-alpha-(D-2-aminoadipyl)-N-2-heptylamine monoethyl ester (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c67a7bf7d730589303d1fd525025e374
https://pubmed.ncbi.nlm.nih.gov/9321516
https://pubmed.ncbi.nlm.nih.gov/9321516
Autor:
R G, Tirona, K S, Pang
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(8)
The metabolic disposition of simultaneously delivered [14C]salicylamide (SAM) (100 microM) and a tracer concentration of its hydroxylated metabolite [3H]gentisamide (GAM) was studied with single-pass followed by recirculating rat liver perfusion (10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::15ac552b41a0ee0c8d765921647b6ae5
https://pubmed.ncbi.nlm.nih.gov/8869815
https://pubmed.ncbi.nlm.nih.gov/8869815
Autor:
R F, Donnelly, R G, Tirona
Publikováno v:
American journal of hospital pharmacy. 51(4)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4111bda848fa29975d1b38bde0c1174
https://pubmed.ncbi.nlm.nih.gov/8017419
https://pubmed.ncbi.nlm.nih.gov/8017419