Zobrazeno 1 - 10
of 41
pro vyhledávání: '"R G, Schaub"'
Publikováno v:
RNA Technologies in Cardiovascular Medicine and Research ISBN: 9783540787082
Nucleic acid aptamers can fold into a multitude three-dimensional structures allowing them to bind to almost any small molecule, nucleic acid or protein target with high specificity and affinity. Aptamers can be generated in a controlled and entirely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87832bc2a7e31bf6993405d8535c8bd1
https://doi.org/10.1007/978-3-540-78709-9_14
https://doi.org/10.1007/978-3-540-78709-9_14
Autor:
K, McCarthy, P, Stewart, J, Sigman, M, Read, J C, Keith, K M, Brinkhous, T C, Nichols, R G, Schaub
Publikováno v:
Thrombosis and haemostasis. 87(5)
Hemophilia B therapy requires intravenous (IV) infusions of large volumes of factor IX due to the low concentration of factor IX in concentrates (approximately 100 IU/mL). High concentration recombinant factor IX (rFIX) could be a significant advance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::25e0406971a3c3b3319941a537ac5c12
https://pubmed.ncbi.nlm.nih.gov/12038784
https://pubmed.ncbi.nlm.nih.gov/12038784
Autor:
M J, Eppihimer, R G, Schaub
Publikováno v:
Microcirculation (New York, N.Y. : 1994). 8(1)
Leukocyte rolling is recognized as an important event in facilitating the extravasation of leukocytes from the vascular to the interstitial compartment, and is mediated by the selectin family of cell adhesion molecules. The aim of this study was to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e89d4071f4a4cdd3fcb52c835d3380b6
https://pubmed.ncbi.nlm.nih.gov/11296849
https://pubmed.ncbi.nlm.nih.gov/11296849
Publikováno v:
Blood. 94(12)
Interleukin-12 (IL-12) is a heterodimeric cytokine mediating a dynamic interplay between T cells and antigen-presenting cells (APCs). Preclinical studies have demonstrated that recombinant murine IL-12 (rmIL-12) promotes specific antitumor immunity m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eadb6110084e2e9b27e7b45c568c8a3f
https://pubmed.ncbi.nlm.nih.gov/10590071
https://pubmed.ncbi.nlm.nih.gov/10590071
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 3(9)
The antitumor activity of interleukin (IL)-12, a naturally occurring cytokine, has been demonstrated in several murine solid tumors. Animals bearing established B16 melanoma or MB-49 bladder carcinoma were used to study the most effective scheduling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0129d16efd682a82c16789959e75e731
https://pubmed.ncbi.nlm.nih.gov/9815857
https://pubmed.ncbi.nlm.nih.gov/9815857
Publikováno v:
Radiation oncology investigations. 6(2)
Interleukin-12 (IL-12), a naturally occurring cytokine, has demonstrated antitumor activity in several murine solid tumors. The Lewis lung carcinoma was used to study the most effective scheduling of recombinant murine interleukin-12 (rmIL-12) admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ea2ed5e24ff3d99d5081a31c7ae020b7
https://pubmed.ncbi.nlm.nih.gov/9572683
https://pubmed.ncbi.nlm.nih.gov/9572683
Publikováno v:
Molecular reproduction and development. 46(1)
Infiltration of monocytes into arteries is an early event in the pathogenesis of atherosclerosis. This recruitment is interpreted as enhancing lesion development, but it could also be a host response limiting lipid accumulation. The ability of macrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9e07be1379538c4d809deb1466d0872b
https://pubmed.ncbi.nlm.nih.gov/8981369
https://pubmed.ncbi.nlm.nih.gov/8981369
Publikováno v:
Critical reviews in immunology. 17(5-6)
Interleukin 12 (IL-12), a novel heterodimeric protein produced primarily by antigen-presenting cells, serves as a key regulator of innate and adaptive immune responses. In addition to being a potent inducer of IFN-gamma, IL-12 is widely considered to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::611f75582143ba37d1ea6fa60b1b4302
https://pubmed.ncbi.nlm.nih.gov/9419442
https://pubmed.ncbi.nlm.nih.gov/9419442
Autor:
K M, Brinkhous, J L, Sigman, M S, Read, P F, Stewart, K P, McCarthy, G A, Timony, S D, Leppanen, B J, Rup, J C, Keith, P D, Garzone, R G, Schaub
Publikováno v:
Blood. 88(7)
Recombinant human factor IX (rFIX) has been expressed in transduced cultured cell systems since 1985. Because there has been limited in vivo testing of rFIX in hemophilia B subjects, this study was undertaken using the severe hemophilia B canines of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5205d365c730f79b5eb851b928e5237f
https://pubmed.ncbi.nlm.nih.gov/8839853
https://pubmed.ncbi.nlm.nih.gov/8839853
Publikováno v:
International journal of cancer. 65(1)
Interleukin-12 (IL-12) was found to be an active anti-tumor agent in 3 established murine solid tumors: B16 melanoma, Lewis lung carcinoma and renal cell carcinoma (RenCa). IL-12 was well tolerated over a 100-fold dose range. Only the high-dose treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1c57035983b67cd04721e25fb0c53856
https://pubmed.ncbi.nlm.nih.gov/8543401
https://pubmed.ncbi.nlm.nih.gov/8543401