Zobrazeno 1 - 10
of 37
pro vyhledávání: '"R G, Pendleton"'
Publikováno v:
Agents and Actions. 30:393-402
The efficacy of various drugs used to treat ulcerative colitis, (sulfasalazine, 5-aminosalicylate, hydrocortisone) was investigated in a model of acetic acid-induced colitis in the rat. Subsequently, we tested the ability of antioxidant/5-lipoxygenas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd426584292a8baf0de9e292f903b9a8
https://doi.org/10.1007/bf01966304
https://doi.org/10.1007/bf01966304
Publikováno v:
Trends in pharmacological sciences. 19(7)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7f9c18e79bf1ee2cc0318c69c311b810
https://pubmed.ncbi.nlm.nih.gov/9703753
https://pubmed.ncbi.nlm.nih.gov/9703753
Publikováno v:
Life sciences. 59(24)
Drosophila melanogaster, maintained on culture media containing alpha-methyl-p-tyrosine (alpha-MT) at millimolar levels for 7 days, fail to produce viable progeny. Lesser concentrations delay development. This effect of alpha-MT, an inhibitor of tyro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2e5fbc34a1e0e51f8776d62757c39aa3
https://pubmed.ncbi.nlm.nih.gov/8950311
https://pubmed.ncbi.nlm.nih.gov/8950311
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 256(2)
The addition of angiotensin II (AII) and angiotensin III (AIII) to isolated tissue baths produced the same maximal contractile response of rabbit aortic strips. AIII was about 10 times less potent, the slope of its concentration-response curve was le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4ea5b248a6eab45063e368704acfb742
https://pubmed.ncbi.nlm.nih.gov/1993998
https://pubmed.ncbi.nlm.nih.gov/1993998
Autor:
L R, Fitzpatrick, R M, Lambert, C E, Pendley, G E, Martin, J S, Bostwick, G W, Gessner, J E, Airey, R D, Youssefyeh, R G, Pendleton, D L, Decktor
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(2)
RG 12915 [4-[N-(1-azabicyclo[2.2.2.]octan-3-(S)-yl)]2-chloro-cis 5a-(S)-9a-(S)-5a,6,7,8,9,9a-hexahydrobenzofurancarboxamide hydrochloride] is a potent and effective agent against cisplatin-induced emesis in the ferret after i.v. or p.o. administratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41630742260ba0ac476aa6ba04ebe44d
https://pubmed.ncbi.nlm.nih.gov/2166791
https://pubmed.ncbi.nlm.nih.gov/2166791
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 252(1)
To exploit the well documented effect of 2,3-diphosphoglyceric acid (2,3-DPG) in enhancing oxygen delivery by human erythrocytes, we have investigated whether the DPG synthase/phosphatase enzyme system can be targeted to increase DPG levels in the ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba60152f23720d0fd2f721fabb0b1220
https://pubmed.ncbi.nlm.nih.gov/2153800
https://pubmed.ncbi.nlm.nih.gov/2153800
Autor:
R G Pendleton, Henry M. Sarau, J M Roesler, Carey R, Gessner G, J P McCafferty, Goldstein M, Hieble Jp
Publikováno v:
Journal of Cardiovascular Pharmacology. 5:889-897
SK&F 64139 (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) produces a dose-related antihypertensive effect in rats treated with desoxycorticosterone acetate and administered saline in their drinking water (DOCA-salt rats), lowering both systolic and di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bdca1b4a6ce227e8f40657e512f618
https://doi.org/10.1097/00005344-198309000-00029
https://doi.org/10.1097/00005344-198309000-00029
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 197(3)
SKF 64139 is a potent, reversible inhibitor of phenylethanolamine N-methyltransferase; its IC50 concentration in our standard assay system was 1 X 10(-7) M. Kinetically, the compound is a competitive inhibitor with respect to norepinephrine but is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af4f00ca48321fb026865c5a1772dafd
https://pubmed.ncbi.nlm.nih.gov/6786
https://pubmed.ncbi.nlm.nih.gov/6786
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 224(3)
L-643,441 is a highly potent histamine H2-receptor antagonist in guinea-pig atria, acting via a unique mechanism. Unlike ranitidine, the onset of action of this compound was slow and its inhibitory action persisted after repeated washing of the tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::691e6489c23be70251c271a4ab86b7e2
https://pubmed.ncbi.nlm.nih.gov/6131118
https://pubmed.ncbi.nlm.nih.gov/6131118
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 241(1)
A new, highly potent antagonist of gut cholecystokinin (CCK) receptors has been examined for effects upon postprandial biliary and exocrine pancreatic secretion in conscious dogs with chronic duodenal pouches. This drug (L-364,718) markedly inhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::feb8fbcf652e5a266a687f1d0a52fbff
https://pubmed.ncbi.nlm.nih.gov/2437283
https://pubmed.ncbi.nlm.nih.gov/2437283