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Autor:
P H, Houba, E, Boven, I H, van der Meulen-Muileman, R G, Leenders, J W, Scheeren, H M, Pinedo, H J, Haisma
Publikováno v:
International journal of cancer. 91(4)
A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into