Zobrazeno 1 - 10
of 14
pro vyhledávání: '"R G, Kilbourn"'
Publikováno v:
Journal of Applied Physiology. 77:471-475
The cardiovascular effects of nitric oxide blockade were examined in five conscious chronically instrumented dogs. The hypothesis tested was that nitric oxide release plays a role in vascular tone and regional organ blood flow under physiological con
Autor:
R. L. De Jager, Pervin Anklesaria, J. Y. Payne, Ruth L. Katz, Mary Carey, David M. Gershenson, Gabriel N. Hortobagyi, D. L. Branham, S. D. Tucker, Jie Willey, Naoto T. Ueno, R. L. Theriault, P. L. Weiden, Nuhad K. Ibrahim, Joe B. Putnam, Gabriel Lopez-Berestein, Weiya Xia, Mien Chie Hung, Shizhen Zhang, V. Valero, James L. Murray, Nour Sneige, L. Huang, Chandra Bartholomeusz, R. G. Kilbourn, J. K. Wolf, Michael W. Bevers
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 19(14)
PURPOSE: Preclinical studies have demonstrated that the adenovirus type 5 E1A gene is associated with antitumor activities by transcriptional repression of HER-2/neu and induction of apoptosis. Indeed, E1A gene therapy is known to induce regression o
Publikováno v:
The cancer journal from Scientific American. 6
The clinical utility of high-dose intravenous recombinant interleukin (IL)-2 therapy is limited by severe toxicity including hypotension, fever, chills, pulmonary edema, and oliguria Hypotension has been previously shown to result from excessive vasc
Autor:
J. DeAngelo, R. G. Kilbourn
Publikováno v:
Shock, Sepsis, and Organ Failure ISBN: 9783642636721
Septic shock affects approximately 180000 patients per year, accounting for at least 2.5% of Intensive care unit admissions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51658b597b618c1ebd683e0ca7114664
https://doi.org/10.1007/978-3-642-58630-9_3
https://doi.org/10.1007/978-3-642-58630-9_3
Autor:
H, Shahidi, R G, Kilbourn
Publikováno v:
Cancer metastasis reviews. 17(1)
Nitric oxide is an uncharged free radical that mediates a range of physiologic processes in the vasculature. As a principal determinant of vascular tone, the overproduction of nitric oxide has been implicated in the pathogenesis of sepsis- and cytoki
Autor:
Lillian D. Traber, Sharon H. Nelson, Hugo A. Linares, Daniel L. Traber, W. Lingnau, R. G. Kilbourn, Deborah J. Dehring, Roy McGuire
Publikováno v:
The American journal of physiology. 270(1 Pt 2)
We studied the action of nitric oxide synthase (NOS) inhibition on changes in regional blood flow during a continuous infusion of live bacteria. Eighteen ewes were chronically instrumented. After a 7-day recovery period, an infusion of 10(6) colony-f
Autor:
K, Narayanan, L, Spack, K, McMillan, R G, Kilbourn, M A, Hayward, B S, Masters, O W, Griffith
Publikováno v:
The Journal of biological chemistry. 270(19)
Nitric oxide synthase catalyzes the oxidation of a guanidino nitrogen of L-arginine to nitric oxide with concomitant formation of citrulline. Enzyme activity is inhibited by a variety of N omega-monosubstituted L-arginine analogs including N omega-al
Autor:
R. G. Kilbourn, G. A. Fonseca
Publikováno v:
Role of Nitric Oxide in Sepsis and ADRS ISBN: 9783642799228
Renal cell carcinoma affects approximately 28000 patients per year in the United States. The prognosis of patients with this malignancy is poor with a 5-year survival of approximately 15% in patients with metastatic disease. Two major characteristics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90837adb73395df715297965e7c45dd1
https://doi.org/10.1007/978-3-642-79920-4_15
https://doi.org/10.1007/978-3-642-79920-4_15
Autor:
R. G. Kilbourn
Publikováno v:
Shock, Sepsis, and Organ Failure — Nitric Oxide ISBN: 9783642793455
Septic shock is the life-threatening complication of an overwhelming infection in which the immune system releases inflammatory mediators resulting in pathophysiological vasodilation, hematological abnormalities, and major organ dysfunction. Sepsis a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0388eff7c5644f45e5e6ccd40c401a56
https://doi.org/10.1007/978-3-642-79343-1_8
https://doi.org/10.1007/978-3-642-79343-1_8
Publikováno v:
Critical care medicine. 22(11)
To evaluate the hemodynamic effects of the nitric oxide inhibitor, NG-methyl-L-arginine, and dobutamine during experimental endotoxemia.Prospective, randomized, controlled animal study.University research laboratory.Adult, male mongrel dogs.After cat