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of 37
pro vyhledávání: '"R G, Goodwin"'
Publikováno v:
Clinical and Experimental Dermatology
Summary Background The landscape of dermatology services, already rapidly evolving into an increasingly digital one, has been irretrievably altered by the COVID‐19 (SARS‐CoV‐2) pandemic. Data are needed to assess how best to deliver virtual der
Publikováno v:
Clinical and Experimental Dermatology
The entire landscape of dermatology service provision has been transformed by the current SARS-CoV-2 (COVID) pandemic, with virtual working having become the new norm across the UK. A pre-pandemic UK-wide survey of dermatology registrars in training
Publikováno v:
Clinical and Experimental Dermatology
Teledermatology has had an explosive impact on the provision of dermatology services in recent times, and even more so with the unprecedented situation created by the COVID-19 pandemic. Although teledermatology is not presently a feature of the Joint
Autor:
R G Goodwin, C A Smith
Publikováno v:
Apoptosis. 3:83-88
The TNF ligand family member termed TRAIL has been shown to induce apoptosis in a wide variety of transformed cell lines. The normal functions of this cytokine in vivo remain, however, relatively unknown. The complexity of this biological system has
Publikováno v:
The Journal of Immunology. 157:3635-3639
CD30 ligand (CD30L), a member of the TNF family, is a type II membrane protein with a C-terminal extracellular domain that is homologous with the extracellular domains of other TNF family members. Also, like most TNF family members, the N-terminal cy
Publikováno v:
The Journal of Immunology. 152:4749-4757
IL-7 was originally reported as a cytokine produced by stromal cells which supports pre-B cell proliferation in vitro. To determine whether human B cells secrete IL-7 and express IL-7R we studied a wide panel of B cell lines (CLS). In Northern blot a
Publikováno v:
The Journal of Immunology. 151:6882-6890
The 80-kDa TNFR (TNFR80) expressed by activated human T cells is constitutively phosphorylated and undergoes limited proteolytic cleavage (shedding) at the cell surface releasing a 40-kDa soluble TNF-binding protein. Triggering of activated T cells t
Autor:
K M Mohler, D S Torrance, C A Smith, R G Goodwin, K E Stremler, V P Fung, H Madani, M B Widmer
Publikováno v:
The Journal of Immunology. 151:1548-1561
Two forms (monomeric or dimeric) of the extracellular, ligand-binding portion of the human p80 cell-surface receptor for TNF were used to antagonize TNF activity in vitro and in vivo. The dimeric sTNFR:Fc molecule was a more potent inhibitor of TNF t
Autor:
C F Ware, P D Crowe, T L Vanarsdale, J L Andrews, M H Grayson, R Jerzy, C A Smith, R G Goodwin
Publikováno v:
The Journal of Immunology. 147:4229-4238
The expression of TNF-alpha receptors (TNFR) was examined on a CD4+ T cell hybridoma, transformed T cell lines, CTL clones, and activated T cells from peripheral blood to determine the basis of the immunomodulatory activity of TNF on T cell function.
Publikováno v:
The Journal of Immunology. 144:3592-3601
IL-7 cDNA clones were used to isolate clones from the human IL-7 gene locus. Characterization of the clones revealed that the human IL-7 gene contains six exons, distributed over more than 33-kbp. An 18 amino acid insert found in human IL-7, for whic