Zobrazeno 1 - 10
of 17
pro vyhledávání: '"R F Sherwood"'
Autor:
R F, Sherwood
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 11
Despite the exotic appearance and odor of bacterial extracts, it should be remembered that they are predominantly water with only a few percent w/v solids. The twin objectives of preparation prior to chromatography are, therefore, clarification and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5856878d7e3d8ad69de550e7f00643b1
https://pubmed.ncbi.nlm.nih.gov/21431674
https://pubmed.ncbi.nlm.nih.gov/21431674
Publikováno v:
Genetic Manipulation: Techniques and Applications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::435a5a8a65053f6857585c425045c29b
https://doi.org/10.1002/9781444314144.ch22
https://doi.org/10.1002/9781444314144.ch22
Autor:
M. Cresser, R. F. Sherwood, J. D. R. Thomas, R. F. C. Mantoura, W. J. Albery, T. Atkinson, G. S. Wilson
Publikováno v:
Philosophical Transactions of the Royal Society of London. Series A: Physical and Engineering Sciences. 333:93-98
The development of recombinant DNA technology has led to the wide availability of reagents for the analysis of trace quantities of macromolecules and small chemical agents. The cloning and expression of genes coding for the synthesis of proteins and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8a9f85b6a88426baac964f7f90e2106e
https://doi.org/10.1098/rsta.1990.0140
https://doi.org/10.1098/rsta.1990.0140
Galactosylated antibodies and antibody-enzyme conjugates in antibody-directed enzyme prodrug therapy
Autor:
S K, Sharma, K D, Bagshawe, P J, Burke, J A, Boden, G T, Rogers, C J, Springer, R G, Melton, R F, Sherwood
Publikováno v:
Cancer. 73
Antibody directed enzyme prodrug therapy (ADEPT) has been studied as a two- and three-phase system in which an antibody to a tumor-associated antigen has been used to deliver an enzyme to tumor sites where it can convert a relatively nontoxic prodrug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce28a0e737ce4b716a97e68a7d53a7f7
https://pubmed.ncbi.nlm.nih.gov/8306255
https://pubmed.ncbi.nlm.nih.gov/8306255
Publikováno v:
Biochemical pharmacology. 44(12)
A nitroreductase enzyme that has been isolated from Escherichia coli B is capable of bioactivating CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide] to a cytotoxic agent, a property shared with the mammalian enzyme Walker DT diaphorase [NAD(P)H dehydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7daa71e9a5673ece62562961bfa02bb4
https://pubmed.ncbi.nlm.nih.gov/1472095
https://pubmed.ncbi.nlm.nih.gov/1472095
Publikováno v:
Biochemical pharmacology. 44(12)
A nitroreductase enzyme has been isolated from Escherichia coli B. This enzyme is an FMN-containing flavoprotein with a molecular mass of 24 kDa and requires either NADH or NADPH as a cofactor. Partial protein sequence analysis showed extensive homol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::df20235286d22e770c5f64f9fc00b77c
https://pubmed.ncbi.nlm.nih.gov/1472094
https://pubmed.ncbi.nlm.nih.gov/1472094
Autor:
S K, Sharma, K D, Bagshawe, C J, Springer, P J, Burke, G T, Rogers, J A, Boden, P, Antoniw, R G, Melton, R F, Sherwood
Publikováno v:
Disease markers. 9(3-4)
Monoclonal anti-CEA antibody, A5B7, and its fragments conjugated to CPG2 localize to a peak concentration in the LS174T xenografts within 24 h after injection, but enzyme activity persists in plasma such that prodrug injection has to be delayed for 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ec4d2883b2a337754f508781e6f06c8d
https://pubmed.ncbi.nlm.nih.gov/1813212
https://pubmed.ncbi.nlm.nih.gov/1813212
Autor:
K D, Bagshawe, S K, Sharma, C J, Springer, P, Antoniw, J A, Boden, G T, Rogers, P J, Burke, R G, Melton, R F, Sherwood
Publikováno v:
Disease markers. 9(3-4)
Following an extensive series of studies in nude mice with human xenografts a pilot scale clinical trial of antibody directed enzyme prodrug therapy has been initiated. The principle is to activate a relatively inert prodrug to an active cytotoxin by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecbc23a80e0a843717138cb40ab5d74f
https://pubmed.ncbi.nlm.nih.gov/1813213
https://pubmed.ncbi.nlm.nih.gov/1813213
Publikováno v:
Biochemical Journal. 164:461-464
Conjugation of carboxypeptidase G and arginase, two enzymes of therapeutic interest, to a soluble dextran significantly enhanced plasma persistence in normal and tumour-bearing mice. A prolonged decrease in arginine concentrations in plasma of tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e408ece40ccd79298e10bce98ce2f606
https://doi.org/10.1042/bj1640461
https://doi.org/10.1042/bj1640461
Autor:
Robert J. Linhardt, A. Atkinson, C. Lowe, K. Mosbach, D. A. P. Small, D. C. Bishop, I. A. Braude, M. Cais, M. Shimoni, G. Colman, R. R. B. Russel, R. O. Cone, C. R. Carpenter, L. J. Crane, H. E. Ramsden, P. K. Donahoe, G. P. Budzik, D. A. Swann, H. F. Dvorak, D. R. Senger, L. F. Estis, J. W. Freytag, J. M. Gershoni, S. G. Gordon, P. Hughes, C. R. Lowe, R. F. Sherwood, R. E. Jordan, O. J. Lantero, Y. Miyashiro, M. Ogawa, Y. Yamazaki, S. Igarasi, S. A. Olexa, A. Z. Budzynski, N. Pancham, T. Zuffi, R. A. Reynolds, R. R. B. Russell, H. Sato, K. Sasaki, K. Takagi, H. Hiratani, Y. Yuki, F. Shamizu, Y. OHmotot, K. Imagawa, L. H. Smith, R. L. Teplitz, Y. H. Tan, J. H. Smith, T. R. Zuffi
Publikováno v:
Applied Biochemistry and Biotechnology. 11:409-426
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e598f0922158f504651e3cc6cc4ed4c
https://doi.org/10.1007/bf02798674
https://doi.org/10.1007/bf02798674