Zobrazeno 1 - 6
of 6
pro vyhledávání: '"R F Azad"'
Publikováno v:
Antimicrobial Agents and Chemotherapy. 40:2004-2011
ISIS 2922 is a phosphorothioate oligonucleotide that is complementary to human cytomegalovirus (CMV) immediate-early (IE) RNA and that exhibits potent and specific antiviral activity against CMV in cell culture assays. Specific assay systems were dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d35f3feb53228b369c5f79b2a81cf9
https://doi.org/10.1128/aac.40.9.2004
https://doi.org/10.1128/aac.40.9.2004
Publikováno v:
Antimicrobial Agents and Chemotherapy. 42:971-973
A human cytomegalovirus mutant that was isolated for resistance (10-fold) to the antisense oligonucleotide fomivirsen (ISIS 2922) exhibited cross-resistance to a modified derivative of fomivirsen with an identical base sequence but little or no resis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1124daabb96d292415067d040e14b9c7
https://doi.org/10.1128/aac.42.4.971
https://doi.org/10.1128/aac.42.4.971
Autor:
R F Azad, Boyd Conklin, Ronnie C. Hanecak, M C Fox, Vickie L. Brown-Driver, Hong Zhang, Kevin P. Anderson
Publikováno v:
Antimicrobial agents and chemotherapy. 43(2)
Hepatitis C virus (HCV) is the major cause of non-A, non-B hepatitis worldwide. Current treatments are not curative for most infected individuals, and there is an urgent need for both novel therapeutic agents and small-animal models which can be used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b4dc18b40bc0bd9dad3b93aa221a77
https://pubmed.ncbi.nlm.nih.gov/9925530
https://pubmed.ncbi.nlm.nih.gov/9925530
Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes
Autor:
Ronnie C. Hanecak, M C Fox, S Furusako, R F Azad, Vickie L. Brown-Driver, Kevin P. Anderson, Chikateru Nozaki, H Sasmor, C Ford
Genetic and biochemical studies have provided convincing evidence that the 5' noncoding region (5' NCR) of hepatitis C virus (HCV) is highly conserved among viral isolates worldwide and that translation of HCV is directed by an internal ribosome entr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa0e5533db5d9fc3d86b8cf8cbe1537
https://europepmc.org/articles/PMC190476/
https://europepmc.org/articles/PMC190476/
Publikováno v:
Antiviral research. 28(2)
ISIS 2922 is a phosphorothioate oligonucleotide with potent antiviral activity against human cytomegalovirus (HCMV) in cell culture assays. The ability of ISIS 2922 to inhibit replication of HCMV when used in combination with other antiviral agents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b7c4f49f2da1d8f7060118424497ba
https://pubmed.ncbi.nlm.nih.gov/8585764
https://pubmed.ncbi.nlm.nih.gov/8585764
Phosphorothioate oligonucleotides complementary to mRNA of the human cytomegalovirus (HCMV) DNA polymerase gene or to RNA transcripts of the major immediate-early regions 1 and 2 (IE1 and IE2) of HCMV were evaluated for antiviral activity in a 96-wel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b50b855b181a4481cc874bf5dc30d0b0
https://europepmc.org/articles/PMC188097/
https://europepmc.org/articles/PMC188097/