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CHAPTER 3. Do Polychlorinated Biphenyls and Associated Chemicals Exacerbate Aging-Related Declines in Brain Function?

Autor: R. F. Seegal

Polychlorinated biphenyls (PCBs) are members of a larger class of organic compounds known as halogenated aromatic hydrocarbons. PCBs were used in the manufacture of power capacitors and transformers, in paints and plastics, and in weather proof seala

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::91dd06dfdfe86b3614ecf1d9905da600
https://doi.org/10.1039/9781849734660-00083

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Subchronic Toxicity of 3,3′,4,4′,5-Pentachlorobiphenyl in the Rat

Autor: I. CHU, D. C. VILLENEUVE, A. YAGMINAS, P. LECAVALIER, R. POON, M. FEELEY, S. W. KENNEDY, R. F. SEEGAL, H. HÄKANSSON, U. G. AHLBORG, V. E. VALLI

Publikováno v: Toxicological Sciences. 22:457-468

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da06f7278f8852c27b1df8113e829798
https://doi.org/10.1093/toxsci/22.3.457

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Polychlorinated biphenyls and methylmercury alter intracellular calcium concentrations in rat cerebellar granule cells

Autor: J C, Bemis, R F, Seegal

Publikováno v: Neurotoxicology. 21(6)

Assessments of the effects of exposure of human populations to complex environmental contaminants, such as those found in contaminated fish, necessitate the investigation of contaminant interactions. We have recently demonstrated that polychlorinated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::321d49aba29c705e9d6c70a2598c9562
https://pubmed.ncbi.nlm.nih.gov/11233759

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ETAP changes

Autor: N P.E., Vermeulen, R F., Seegal, J H., Koeman

Publikováno v: Vermeulen, N P E, Seegal, R F & Koeman, J 2001, ' ETAP changes ', Environmental Toxicology and Pharmacology, vol. 10, no. 1-2, pp. V . https://doi.org/10.1016/s1382-6689(01)00086-2
Environmental Toxicology and Pharmacology, 10(1-2). Elsevier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f02c54d627740fa1de8939bbe60596
https://doi.org/10.1016/s1382-6689(01)00086-2

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2,2',6,6'-Tetrachlorobiphenyl is estrogenic in vitro and in vivo

Autor: K F, Arcaro, L, Yi, R F, Seegal, D D, Vakharia, Y, Yang, D C, Spink, K, Brosch, J F, Gierthy

Publikováno v: Journal of cellular biochemistry. 72(1)

Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants whose effects on biological systems depend on the number of and the positions of the chlorine substitutions. In the present study we examined the estrogenicity of the fully or

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fe0c6eeefa720ff5ac6f47784ad50d3
https://pubmed.ncbi.nlm.nih.gov/10025670

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Subchronic toxicity of PCB 105 (2,3,3',4,4'-pentachlorobiphenyl) in rats

Autor: I, Chu, R, Poon, A, Yagminas, P, Lecavalier, H, Håkansson, V E, Valli, S W, Kennedy, A, Bergman, R F, Seegal, M, Feeley

Publikováno v: Journal of applied toxicology : JAT. 18(4)

The toxicity of 2,3,3',4,4'-pentachlorobiphenyl (PCB 105) was investigated in Sprague-Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption were not affected and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::731f0aa1840a4e4539777e855ab593e9
https://pubmed.ncbi.nlm.nih.gov/9719429

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Aroclors 1254 and 1260 reduce dopamine concentrations in rat striatal slices

Autor: M A, Chishti, J P, Fisher, R F, Seegal

Publikováno v: Neurotoxicology. 17(3-4)

Striatal slices from adult male Wistar-derived rats were exposed to a 1:1 mixture of Aroclor 1254:1260 at concentrations in media of 10, 20, 40, 60 or 100 ppm for 6 hr. Following exposure, slices and media were analyzed by high-performance liquid chr

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https://pubmed.ncbi.nlm.nih.gov/9086486

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Long-term alterations in regional brain serotonin metabolism following maternal polychlorinated biphenyl exposure in the rat

Autor: D C, Morse, R F, Seegal, K O, Borsch, A, Brouwer

Publikováno v: Neurotoxicology. 17(3-4)

Pregnant Wistar WU rats were administered PCBs (0, 5 or 25 mg Aroclor 1254 per kg body weight) by gavage on day 10 to 16 of gestation. Levels of biogenic amines were measured in the lateral olfactory tract, prefrontal cortex, striatum, hippocampus an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ec892162462c8efe23502ab3c5f1bc2
https://pubmed.ncbi.nlm.nih.gov/9086483

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Toxicity of 2,2',4,4',5,5'-hexachlorobiphenyl in rats: effects following 90-day oral exposure

Autor: I, Chu, D C, Villeneuve, A, Yagminas, P, Lecavalier, R, Poon, M, Feeley, S W, Kennedy, R F, Seegal, H, Håkansson, U G, Ahlborg, V E, Valli, A, Bergman

Publikováno v: Journal of applied toxicology : JAT. 16(2)

The subchronic toxicity of 2,2',4,4',5,5'-hexachlorobiphenyl (PCB 153) was investigated in rats after 13 weeks of dietary exposure. Groups of 10 male and 10 female rats were administered PCB 153 in their diet at levels of 0.05, 0.50, 5.0 or 50 ppm fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c5d4b07b296293943852022236eda87a
https://pubmed.ncbi.nlm.nih.gov/8935785

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