Výsledky vyhledávání - "R F, Krzesicki"

Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat

Autor: F F, Sun, P S, Lai, G, Yue, K, Yin, R G, Nagele, D M, Tong, R F, Krzesicki, J E, Chin, P Y, Wong

Publikováno v: Inflammation. 25(1)

We examined the mRNA expression of cytokines, chemokines, integrins, and selectins in colon lesions of rat colitis with a semi-quantitative RT-PCR assay. Rat colitis was induced by trinitrobenzene sulfonic acid (TNBS) in 50% ethanol. Within 24 h, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::af8f0d63e79e1822482ae4e72e449d77
https://pubmed.ncbi.nlm.nih.gov/11293664

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Preclinical evaluation of anti-inflammatory activities of the novel pyrrolopyrimidine PNU-142731A, a potential treatment for asthma

Autor: J E, Chin, C A, Hatfield, G E, Winterrowd, R F, Krzesicki, K L, Shull, S F, Fidler, K P, Kolbasa, J R, Brashler, R L, Griffin, W E, Fleming, J M, Justen, L S, Banitt, G L, Bundy, I M, Richards

Publikováno v: The Journal of pharmacology and experimental therapeutics. 290(1)

The anti-inflammatory properties of a novel pyrrolopyrimidine, PNU-142731A, in a murine model of antigen-induced eosinophilic lung inflammation are described. PNU-142731A, when given orally, demonstrated a dose-related inhibition of eosinophil- and l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::513c34a80c0895f815c9f4a616865c11
https://pubmed.ncbi.nlm.nih.gov/10381775

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Airway recruitment of leukocytes in mice is dependent on alpha4-integrins and vascular cell adhesion molecule-1

Autor: Jia En Chin, G. E. Winterrowd, R. L. Griffin, R. F. Krzesicki, J. R. Brashler, S. F. Fidler, K. P. Kolbasa, S. L. Vonderfecht, C. A. Hatfield, L. M. Sly, I. M. Richards, N. D. Staite

Publikováno v: The American journal of physiology. 272(2 Pt 1)

The involvement of the alpha4-integrin very late activation antigen 4 and vascular cell adhesion molecule-1 (VCAM-1) in leukocyte trafficking into the airways of ovalbumin (OA)-sensitized and OA-challenged mice was investigated using in vivo administ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::407822464f9d6f3bbf5f4250b1569635
https://pubmed.ncbi.nlm.nih.gov/9124372

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Regulation of expression of IL-1 receptor antagonist protein in human synovial and dermal fibroblasts

Autor: R F, Krzesicki, C A, Hatfield, M J, Bienkowski, J C, McGuire, G E, Winterrowd, D L, Chapman, A E, Berger, R N, McEwan, D B, Carter, J G, Chosay

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 150(9)

The IL-1R antagonist protein (IRAP) is a competitive inhibitor of IL-1, which is predominantly synthesized by monocytes. We show that this molecule is also expressed in human synovial fibroblasts and dermal fibroblasts (CRL 1445). IRAP mRNA was regul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0f7cebd9e31f041fd13bd2c58706a677
https://pubmed.ncbi.nlm.nih.gov/8473746

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Role of cytokines in inflammatory synovitis. The coordinate regulation of intercellular adhesion molecule 1 and HLA class I and class II antigens in rheumatoid synovial fibroblasts

Autor: J E, Chin, G E, Winterrowd, R F, Krzesicki, M E, Sanders

Publikováno v: Arthritis and rheumatism. 33(12)

This study was undertaken in an effort to understand the role of cytokines in T lymphocyte trafficking into inflamed synovium and in the potential enhancement of antigen presentation by human synovial fibroblasts. We found that interleukin-1 beta (IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e9470a19cf1872b9a513892e3a79a17
https://pubmed.ncbi.nlm.nih.gov/1701992

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Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form

Autor: J S, Beebe, K, Mountjoy, R F, Krzesicki, F, Perini, R W, Ruddon

Publikováno v: The Journal of biological chemistry. 265(1)

The malignant trophoblastic cell line JAR was used as a model system to study protein folding in intact cells. We have used this model previously to identify conformational intermediates in the production of an assembly-competent form of the human ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6d94d2f423439b4afca8794a49cf4bcb
https://pubmed.ncbi.nlm.nih.gov/1688430

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Two-dimensional gel electrophoresis of cell proteins in childhood leukemia, with silver staining: a preliminary report

Autor: R M Heyn, G S Stevens, Sam M. Hanash, D G Tubergen, R F Krzesicki, B. B. Rosenblum, L Sandy, James V. Neel

Publikováno v: Clinical Chemistry. 28:1026-1030

We have investigated the potential of two-dimensional electrophoresis for identifying differences in protein patterns between acute lymphocytic (ALL) and acute myelogenous leukemia (AML). We studied blood cells directly isolated from seven children w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::567d6762e37839411e537ea2ac869035
https://doi.org/10.1093/clinchem/28.4.1026

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The use of drugs to dissect the pathway for secretion of the glycoprotein hormone chorionic gonadotropin by cultured human trophoblastic cells

Autor: B P, Peters, M, Brooks, R J, Hartle, R F, Krzesicki, F, Perini, R W, Ruddon

Publikováno v: The Journal of biological chemistry. 258(23)

Agents that affect intracellular cation and pH gradients and inhibit energy production have been tested for their ability to modulate the processing and secretion of the free alpha subunit and the alpha beta dimer of human chorionic gonadotropin (hCG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ddf7fd055c391d532046745e08fc91c5
https://pubmed.ncbi.nlm.nih.gov/6417140

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The biosynthesis, processing, and secretion of laminin by human choriocarcinoma cells

Autor: B P, Peters, R J, Hartle, R F, Krzesicki, T G, Kroll, F, Perini, J E, Balun, I J, Goldstein, R W, Ruddon

Publikováno v: The Journal of biological chemistry. 260(27)

Laminin, a glycoprotein component of basal laminae, is synthesized and secreted in culture by a human malignant cell line (JAR) derived from gestational choriocarcinoma. Biosynthetically labeled human laminin subunits A (Mr approximately 400,000) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b2e651ad1b4f3e59b4bbf7928ab5d66
https://pubmed.ncbi.nlm.nih.gov/3840485

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